Abstract:
OBJECTIVE:This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). METHOD:A total of 66 siblings of patients with COS were assessed for symptoms of schizophrenia spectrum PDs (avoidant, paranoid, schizoid, schizotypal). Structural magnetic resonance images were obtained at approximately 2-year intervals from the siblings and from 62 healthy volunteers matched for age, sex, ethnicity, and handedness. Cortical thickness measures were extracted. Mixed effect regression models were used to test the relationship between symptoms and cortical gray matter thickness in siblings. Cortical thinning was also tested longitudinally in healthy volunteers and siblings. RESULTS:Cortical thinning was found to correlate with symptoms of schizotypal and, to a lesser extent, schizoid PDs. Thinning was most pronounced in the left temporal and parietal lobes and right frontal and parietal regions. Gray matter loss was found to be continuous with that measured in COS. Longitudinal thinning trajectories were found not to differ between siblings and healthy volunteers. CONCLUSION:The present investigation of cortical thinning in siblings of patients with COS indicates that symptoms of schizophrenia spectrum PDs correlate with regional gray matter loss. This finding supports the idea of cortical thinning as a schizophrenia endophenotype.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Watsky RE,Pollard KL,Greenstein D,Shora L,Dillard-Broadnax D,Gochman P,Clasen LS,Berman RA,Rapoport JL,Gogtay N,Ordóñez AEdoi
10.1016/j.jaac.2015.11.008subject
Has Abstractpub_date
2016-02-01 00:00:00pages
130-136issue
2eissn
0890-8567issn
1527-5418pii
S0890-8567(15)00754-6journal_volume
55pub_type
杂志文章abstract::Ninety-two sexually abused children were studied using structured interviews and standardized instruments to determine the frequency of post-traumatic stress disorder (PTSD) and associated symptoms. Of these sexually abused children, 43.9% met DSM-III-R PTSD criteria; 53.8% of children abused by fathers, 42.4% abused ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199209000-00015
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence of encopresis/enuresis, relationship between maternal hostility and encopresis, parent-child concordance of reporting encopresis/enuresis, and familial aggregation of enuresis in subjects with a prepubertal and early adolescent bipolar-I disorder phenotype (PEA-BP), attention-deficit...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/01.chi.0000172554.26349.dd
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To examine the validity of the Suicide Risk Screen (SRS) for identifying suicide-risk youths among potential high school dropouts. METHOD:Five hundred eighty-one potential dropouts, aged 14 to 20 years, participated in a 3-stage case identification protocol. A potential dropout pool was created in 7 schools;...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199912000-00011
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Childhood conduct problems are associated with poor functioning in early adulthood. We tested a series of hypotheses to understand the mechanisms underlying this association. METHOD:We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a birth cohort of 2,232 twins born in England and Wa...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2017.09.437
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:As part of the Journal's 10-year Research Update Reviews, a series of articles will be presented on the role of rating scales in child and adolescent psychiatry. The first article in the series summarizes principles underlying scale functioning. METHOD:Sources were reviewed regarding testing theory, scale de...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-200202000-00004
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To examine the content and structure of children's play narratives in a large sample of 5-year-olds in order to replicate previous findings, explore the role of gender differences, and identify a pattern that can provide useful information about children's behavior. METHOD:The MacArthur Story Stem Battery a...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200008000-00017
更新日期:2000-08-01 00:00:00
abstract::This Clinical Update reviews the use of telepsychiatry to deliver psychiatric, mental health, and care coordination services to children and adolescents across settings as direct service and in collaboration with primary care providers or other clinicians. The update defines terms and presents the current status of te...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,实务指引
doi:10.1016/j.jaac.2017.07.008
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore sex differences in autistic traits in relation to diagnosis, to elucidate factors that might differentially impact whether girls versus boys meet diagnostic criteria for autism or a related autism spectrum disorder (ASD). METHOD:Data from a large population-based sample of childre...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2012.05.018
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Although increased evidence of disproportionate psychosocial risk and other health problems encountered by lesbian, gay male, and bisexual (LGB) youths has emerged, no study has described how the topic of homosexuality is addressed within child and adolescent residency psychiatry training. METHOD:Residency t...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199706000-00012
更新日期:1997-06-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/CHI.0b013e31803062d3
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To examine potential external validators for oppositional defiant disorder (ODD) and attention-deficient/hyperactive disorder (ADHD) symptoms in a Ukrainian community-based sample of 600 children age 10 to 12 years old and evaluate the nature of co-occurring ODD and ADHD symptoms using mother- and teacher-def...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000120019.48166.1e
更新日期:2004-06-01 00:00:00
abstract::Minimizing the duration of untreated psychosis and providing comprehensive early intervention including the use of antipsychotics reflects best practice in the treatment of first-episode psychosis (FEP).1 The adverse effects of second-generation antipsychotics (SGAs) are well known, namely, weight gain, hyperglycemia,...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2019.03.019
更新日期:2019-11-01 00:00:00
abstract::Thirty 6- to 9-year-old boys were rated by their mothers and teachers as being pervasively hyperactive, situationally hyperactive, or not hyperactive at home or school. Maternal characteristics and perceptions of their children's behavior problems were collected. Children's global and molecular social skills were also...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199007000-00008
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later off...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.jaac.2012.08.019
更新日期:2012-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199609000-00014
更新日期:1996-09-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,信件
doi:10.1016/j.jaac.2019.07.953
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To clarify the relationship between scales and structured diagnostic interview diagnoses, the authors used a two-stage screening method to study 201 military families with one or more children ages 5 to 17. METHOD:Parents and children were interviewed with the Diagnostic Interview Schedule for Children (DISC...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199303000-00022
更新日期:1993-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2011.01.009
更新日期:2011-05-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200212000-00015
更新日期:2002-12-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jaac.2014.09.015
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:The authors examined the applicability of personality disorder criteria to adolescent inpatients by evaluating internal consistency and criterion overlap. METHOD:Thirty-eight adolescents and 28 adults were assessed with the Personality Disorder Examination. Within-category cohesiveness (internal consistency)...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/00004583-199902000-00020
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVES:To determine whether preadolescent physical abuse raises the risk of adolescent suicidal behavior, to examine potential mediators and moderators of the relationship between preadolescent abuse and adolescent suicidality, and to examine whether distal (preadolescent) risk factors add to proximal (adolescent) ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/chi.0b013e318054e702
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Youths with euthymic bipolar disorder (BD) have a deficit in face-emotion labeling that is present across multiple emotions. Recent research indicates that youths at familial risk for BD, but without a history of mood disorder, also have a deficit in face-emotion labeling, suggesting that such impairments may...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/CHI.0b013e318188832e
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Body dysmorphic disorder (BDD) typically starts in adolescence, but evidence-based treatments are yet to be developed and formally evaluated in this age group. We designed an age-appropriate cognitive-behavioral therapy (CBT) protocol for adolescents with BDD and evaluated its acceptability and efficacy in a ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jaac.2015.08.011
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Anorexia nervosa is a life-threatening condition, with significant risk for death due to cardiac complications. The objective of this study was to analyze the cardiac involvement in anorexia nervosa and to study the reversibility of cardiac abnormalities. METHOD:Thirty-one consecutive adolescents (aged 12 to...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.CHI.0000046867.56865.EB
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To examine the individual and family characteristics of children and adolescents with high levels of hopelessness. METHOD:One hundred inpatient youngsters participated in the study. Several measures, including the Hopelessness Scale for Children, Problem Behavior Scale of the Scales of Independent Behavior, ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/S0890-8567(09)66575-8
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:Investigating dimensions of oppositional symptoms may help to explain heterogeneity of etiology and outcomes for mental disorders across development and provide further empirical justification for the DSM-5-proposed modifications of oppositional defiant disorder (ODD). However, dimensions of oppositionality h...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2013.01.004
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To examine the lifetime prevalence of medical and nonmedical use of prescription stimulants (e.g., Adderall, Concerta, Ritalin, Dexedrine) among high school seniors in the United States, and to assess substance use behaviors (i.e., cigarette smoking, binge drinking, marijuana, and other drug use) based on lif...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2013.09.005
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine whether adolescents with major depressive disorder have disturbances in their cellular immunity and to study whether the immunological changes detected are specific to depression or are general responses to stress. METHOD:Twenty subjects with major depressive disorder, 17 nondepressed subjects w...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199406000-00008
更新日期:1994-06-01 00:00:00
abstract::A twin study examines the relationship of affect attunement to four factors of development: zygosity, temperament, attachment, and twin preference. Affect attunement occurs when an infant expresses affect and a mother responds cross-modally, matching duration, intensity, and rhythm. A sample of 16, same sex, healthy t...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198903000-00017
更新日期:1989-03-01 00:00:00