A multiple primary carcinoma consisting of leukoplakia and SCC: a case report with p53 mutation analysis.

abstract：:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patien...

journal_title：Anticancer research

authors： Yamada T,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Inagaki D,Yamamoto N,Sato T,Fujii S,Numata K,Kunisaki C,Shiozawa M,Morinaga S,Akaike M,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIM:In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identi...

journal_title：Anticancer research

authors： Hagi T,Nakamura T,Sugino Y,Matsubara T,Asanuma K,Sudo A

更新日期：2018-06-01 00:00:00

abstract：:We have previously found that in one of two human melanoma cell lines, potent increase in the polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), correlate with growth sensitivity to the spermine analog, N1, N12-bis(ethyl) spermine (BESPM). Herein, we examine the generality of this SSAT res...

journal_title：Anticancer research

authors： Shappell NW,Miller JT,Bergeron RJ,Porter CW

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

journal_title：Anticancer research

authors： Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. PATIENTS AND METHODS:Fifty consecutive patients with T2-4 GBC who underwent surgery were r...

journal_title：Anticancer research

authors： Okada K,Kawai M,Ueno M,Hirono S,Miyazawa M,Hayami S,Shimizu A,Shigekawa Y,Kitahata Y,Miyamoto A,Yamaue H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND/AIM:γδ T cells mediate cytotoxicity against prostate cancer (PCa) cells in vitro; however, the clinical efficacy of γδ T cell-targeted immunotherapy for recurrent and metastatic PCa is unsatisfactory. We hypothesized that the resistance of recurrent and metastatic PCa to γδ T cells is related to the presence...

journal_title：Anticancer research

authors： Miyashita M,Tomogane M,Nakamura Y,Shimizu T,Fujihara A,Ukimura O,Ashihara E

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIM:AKT, also known as protein kinase B (PKB), is an established therapeutic target in cancer and its inhibitors are increasingly designed. The anti-cancer potential of a compound class naphthoquinones has been constantly realized. The current work aimed to explore AKT1 inhibitors from 1,4-naphthoquionone de...

journal_title：Anticancer research

authors： Rehan M,Mostafa M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:Previous studies have shown discrepancies between patient's desired and actual death place. As planning of family support and involvement of palliative home care teams seem to improve the chance to meet patients preferences, geographical availability of specialized palliative home care could influence pl...

journal_title：Anticancer research

authors： Nilsson J,Axelsson B,Holgersson G,Carlsson T,Bergqvist M,Bergstrom S

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

journal_title：Anticancer research

authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of docetaxel plus S-1 combination chemotherapy as a first-line treatment in patients with advanced or recurrent gastric cancer was verified retrospectively. PATIENTS AND METHODS:Eighteen patients with advanced or recurrent gastric cancer were enrolled. The regimen used was intravenou...

journal_title：Anticancer research

authors： Tsutani Y,Ohara M,Suzuki T,Minami K,Miyahara E,Kameda A,Noso Y

更新日期：2009-07-01 00:00:00

abstract：:CD62L is the human homologue of the murine lymphocyte homing receptor, mel-14. We investigated CD62L + cells in the spleen from patients with gastric cancer. Flow cytometric analysis revealed that CD62L + cells were decreased in the peripheral blood, but inversely increased in the spleen in parallel with disease progr...

journal_title：Anticancer research

authors： Noma K,Yamaguchi Y,Okita R,Matsuura K,Toge T

更新日期：2005-01-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate how treatment with everolimus changes readouts of the pulmonary function test (PFT) in patients with metastatic renal cell carcinoma (mRCC). We also attempted to determine whether changes of PFT or everolimus-associated non-infectious pneumonitis (NIP) might affect the e...

journal_title：Anticancer research

authors： Park K,Kim HJ,Lee JL,Lee KH,Jeong IG,Song C,Hong BS,Hong J,Kim CS,Ahn H

更新日期：2014-10-01 00:00:00

abstract：:Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

journal_title：Anticancer research

authors： D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Understanding molecular abnormalities could potentially lead to novel investigational approaches in the molecular epidemiology of lung cancer. These might include the identification of patients at high risk for primary NSCLC and the surveillance of patients with known NSCLC who are being treated using lung-s...

journal_title：Anticancer research

authors： Curigliano G,Ferretti G,Mandalà M,De Pas T,Calabrò MG,Solli P,Noberasc C,de Braud F

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND/AIM:Chemotherapy-associated toxicity is one of the limiting factors regarding treatment efficacy, patient outcome and quality of life in this collective. Underweight or obese patients represent a major group in which the therapy seems to be more challenging. The aim of this analysis was to evaluate the impac...

journal_title：Anticancer research

authors： Grabowski JP,Richter R,Rittmeister H,Chekerov R,Woopen H,Sehouli J

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:Previous genetic and morphologic characterisation of mucinous tubular and spindle cell carcinoma (MTSCC) have yielded controversial results. The aim of this study was to explain the phenotypic heterogeneity of MTSCC diagnosed by genetic means. MATERIALS AND METHODS:We analyzed 7 MTSCC by array CGH and m...

journal_title：Anticancer research

authors： Banyai D,Vastag F,Yusenko M,Bugert P,Kovacs G

更新日期：2017-03-01 00:00:00

abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

journal_title：Anticancer research

authors： Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung cancer patients. MATERIALS AND METHODS:We evaluated the rates of interferon (IFN)-gamma+/CD4+ cells (Th1), interleukin (IL)-4+ /CD4+ cells (Th2), IFN-gamma+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2...

journal_title：Anticancer research

authors： Ito N,Suzuki Y,Taniguchi Y,Ishiguro K,Nakamura H,Ohgi S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Interleukin 32 (IL32) is an intracellular pluripotent cytokine produced by epithelial cells, monocytes, T-lymphocytes and natural killer cells and seems to be involved in the pathogenesis of cancer and inflammatory diseases. Our purpose was to assess the role of protein expression and genetic polymorphisms o...

journal_title：Anticancer research

authors： Shamoun L,Kolodziej B,Andersson RE,Dimberg J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...

journal_title：Anticancer research

authors： Oremek GM,Müller R,Sapoutzis N,Wigand R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Expression of novel stem cell-associated marker human embryonic stem cell 77 (HES77) was studied in rectal neuroendocrine tumors (NETs), which comprise 10 to 15% of gastroenteropancreatic NETs, some with metastatic potential. MATERIALS AND METHODS:WHO 2010 classification was applied, and immunohistochemical...

journal_title：Anticancer research

authors： Jernman J,Hagström J,Mäenpää H,Välimäki MJ,Haapasalo H,Nilsson O,Fermér C,Haglund C,Arola J

更新日期：2015-07-01 00:00:00

abstract：:We generated a recombinant immunotoxin, named scFv(MGR6)-Cla, composed of the Fv region of an anti ErbB2 monoclonal antibody (MGR6) fused to clavin, a type 1 ribosome-inactivating protein (RIP) from Aspergillus clavatus. ErbB2 is a tyrosine kinase receptor which is overexpressed in most adenocarcinomas; clavin is a 17...

journal_title：Anticancer research

authors： D'Alatri L,Di Massimo AM,Anastasi AM,Pacilli A,Novelli S,Saccinto MP,De Santis R,Mele A,Parente D

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIM:The utility of nanoparticle albumin-bound paclitaxel (nab-PTX) monotherapy in patients with relapsed small-cell lung cancer (SCLC) has not been fully evaluated. We aimed to investigate the efficacy and safety of nab-PTX monotherapy in relapsed SCLC patients, including heavily treated patients. PATIENTS ...

journal_title：Anticancer research

authors： Nakao M,Fujita K,Suzuki Y,Arakawa S,Sakai Y,Sato H,Muramatsu H

更新日期：2020-03-01 00:00:00

abstract：:A rare case and the first reported in Italy of a classic form of colorectal Kaposi's sarcoma, associated with ulcerative rectocolitis, is presented. Following a total proctocolectomy, the patient was disease-free at four years. Some epidemiological risk factors such as sex, age, place of birth and both advanced malari...

journal_title：Anticancer research

authors： Tedesco M,Benevolo M,Frezza F,Mancini R,Carone MD,Mottolese M,Cosimelli M

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:In the present study, 3 cytotoxic agents were combined as front-line chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. All 3 drugs have been used in other 2-agent combinations and have been shown to be effective as first-line therapy. PATIENTS AND METHODS:Sixty-one (53 male, 8 female, me...

journal_title：Anticancer research

authors： Dimitroulis J,Toubis M,Antoniou D,Marosis C,Armenaki U,Stathopoulos GP,Giamboudakis P,Veslemes M,Michalopoulou P,Christou F,Georgatou N,Grigoratou T,Karaindros D,Katis K,SOLCA Study Group.

更新日期：2006-03-01 00:00:00

abstract：:The aim of this project was to study the kinetics of both Tl and Tc-99m MIBI in PBM by evaluating tumor to normal tissue ratio in early (E) images acquired within 1/2 hour and delayed (D) images acquired three hours following the i.v. injection of 3 mCi (111 MBq) of Tl and 20 mCi (740 MBq) of MIBI on 2 separate days i...

journal_title：Anticancer research

authors： Omar WS,Eissa S,Moustafa H,Farag H,Ezzat I,Abdel-Dayem HM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The association of TN expression, tumour grading and expression of commonly used histopathologic prognostic factors (p53 and estrogen receptor) was examined in 62 cases of invasive ductal carcinoma of the breast. MATERIAL AND METHODS:Following histological grading immunohistochemical reactions were undertak...

journal_title：Anticancer research

authors： Tökés AM,Hortoványi E,Csordás G,Kulka J,Mózes G,Hatalyák A,Kádár A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Ethanol injection is widely used in liposome preparation. However, the parameters determining particle size distribution of the liposomal preparation has not been fully defined. MATERIALS AND METHODS:A syringe pump-driven microfluidic injection device was used to produce liposomes under different conditions...

journal_title：Anticancer research

authors： Pradhan P,Guan J,Lu D,Wang PG,Lee LJ,Lee RJ

更新日期：2008-03-01 00:00:00

abstract：:An MCF-7 human breast cancer line variant (MCF-7/MPA), resistant to medroxyprogesterone-acetate (MPA), was obtained by continuous exposure in vitro to the drug. MCF-7/MPA cells were grown in the presence of 12.5 x 10(-6) M MPA and were selected by increasing the concentration of the drug in the growth medium in a step...

journal_title：Anticancer research

authors： Gibelli N,Zibera C,Sica G,Carbone M,Pedrazzoli P,Robustelli della Cuna G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIM:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy due to its selective ability to induce apoptosis of cancer cells. However, some cancer cells are resistant to TRAIL. Here, we demonstrated that treatment with TRAIL, in combination with equol, sens...

journal_title：Anticancer research

authors： Kim EY,Kim AK

更新日期：2013-03-01 00:00:00