Abstract：
:Benign schwannomas are common tumors of the cranial and peripheral nerves, causing pain and loss of function. The development of effective therapy for these tumors has been hampered by the lack of relevant experimental in vivo models for convenient testing. Here, we describe a novel schwannoma model in which an immortalized human schwannoma cell line, HEI-193, established from an neurofibromatosis type 2 patient, has been stably transduced with fluorescent protein and luciferase reporters and implanted within the sciatic nerve of nude mice. These cells reliably formed a tumor within several weeks which had pathologic characteristics of schwannoma tumors. This model system will be useful for investigation of schwannoma biology and for preclinical assessment of therapeutic agents.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Saydam O,Ozdener GB,Senol O,Mizrak A,Prabhakar S,Stemmer-Rachamimov AO,Breakefield XO,Brenner GJdoi
10.1016/j.jneumeth.2010.10.021subject
Has Abstractpub_date
2011-01-30 00:00:00pages
75-7issue
1eissn
0165-0270issn
1872-678Xpii
S0165-0270(10)00602-3journal_volume
195pub_type
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