Abstract：
BACKGROUND:Compared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might offer new tools for research purposes and for diagnosis in patients suffering from mild cognitive impairment or dementia. COMPARISON WITH EXISTING METHODS:Current software proposes a customizable VR environment combined with an analyser module based on regions of interest and some parameters of analysis or pre-calibrated VR mazes with raw data. NEW METHOD:We attempted to create the VRmaze software offering either turnkey mazes with automatic tracking and analysis, or more complex and specific virtual mazes for human brain-behavioural research adaptable to all desired settings and parameters of analysis. The software combines 3D pre-calibrated VR tests or free customizable VR tests with digitized neuropsychological 2D standard and validated tests or tasks. RESULTS:We have tested an ERAM, a MWM and a reverse T-maze on 44 healthy subjects, showing gender differences in terms of navigation strategy. We have observed that the choice of benchmarks, instructions, and experimental parameters influence the performances. CONCLUSION:VRmaze software offers a translational approach for research units that wish to combine animal models and patient evaluations as well as complex 3D tasks and standardized neuropsychological tests combined with an automatic analysis opening a large perspective in the neurosciences to investigate cognitive functions. A clinical module with preconfigured 2- and 3-D tasks should offer clinicians an easy way to evaluate their patients routinely.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Machado ML,Lefèvre N,Philoxene B,Le Gall A,Madeleine S,Fleury P,Smith PF,Besnard Sdoi
10.1016/j.jneumeth.2019.108388subject
Has Abstractpub_date
2019-11-01 00:00:00pages
108388eissn
0165-0270issn
1872-678Xpii
S0165-0270(19)30245-6journal_volume
327pub_type
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