Abstract：
:Following bilateral injection of manganese (Mn) into the rat's motor cortex, electrical stimulation of the cortex is shown to increase the transport, uptake and accumulation of Mn in the corticospinal tract (CST), as assessed by manganese-enhanced magnetic resonance imaging (MEI). T(1)-weighted gradient echo images were acquired in 3-D and displayed in different orientations to anatomically delineate the CST pathway from cortex to spinal cord (SC) at the thoracic level. T(1)-maps of the SC were produced from spin-echo based image data to demonstrate the distribution of the T(1) properties of the SC tissue and to quantitatively assess the T(1)-change occurring in the CST due to the presence of Mn therein. Implications for improving the tract tracing ability with the proposed in vivo approach and its application to spinal cord injury (SCI) research are discussed in terms of aiding future experimental investigations of neuroplasticity following an injury.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Bilgen M,Peng W,Al-Hafez B,Dancause N,He YY,Cheney PDdoi
10.1016/j.jneumeth.2006.02.001subject
Has Abstractpub_date
2006-09-30 00:00:00pages
17-22issue
1-2eissn
0165-0270issn
1872-678Xpii
S0165-0270(06)00109-9journal_volume
156pub_type
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