Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Abstract:

:Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II - threatened preterm labour patients between 24-34 weeks of gestation; III - preterm vaginal delivery patients; IV - healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.

authors

Kuć P,Lemancewicz A,Laudański P,Krętowska M,Laudański T

doi

10.2478/v10042-010-0037-8

subject

Has Abstract

pub_date

2010-09-30 00:00:00

pages

366-70

issue

3

eissn

0239-8508

issn

1897-5631

pii

4865G102180076HX

journal_volume

48

pub_type

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