Quantification of P21 mRNA in biopsy specimens of colon tissue at different stages of neoplastic transformation.

Abstract:

:Induction of the P21 protein is an integral part of cell growth arrest associated with the cellular response to senescence or damage. Changes in the P21 protein level are often observed in tumour cells and it is suggested, that they correlate with malignancy. We studied the P21 gene expression at the mRNA level in biopsy specimens from colitis ulcerosa, adenomas and adenocarcinomas using TaqMan assay. Our results showed, that quantity of the P21 transcript was evidently lower in the cases with adenocarcinomas than in the cases with colitis ulcerosa or adenomas.

authors

Dzierzewicz Z,Kwapisz I,Orchel A,Hudyka K,Wilczok T

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

169-70

eissn

0239-8508

issn

1897-5631

journal_volume

39 Suppl 2

pub_type

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