Abstract:
:Mucins have been shown to be aberrantly overexpressed in various diseases including cystic fibrosis, asthma, and cancer. Recent studies have uncovered the roles of these mucins in the pathogenesis of cancer. The presence of MUC-1 has also been detected on the cell surface of multiple myeloma (MM) cells in peripheral blood and showed direct correlation with tumor mass. In this study, we evaluated the levels of soluble MUC-1 (sMUC-1) in 50 new MM patients and correlated this with the levels of sMUC-1 after treatment. High levels of sMUC-1 were found in 20/50 (40%) MM patients, and in 2/50 (4%) healthy individuals (p = 0.001). According to the ISS, we found significant differences of mean sMUC-1 levels between the first stage of the disease (0.63 ± ± 0.26) and the third (0.93 ± 0.24; p = 0.03), but not with the second stage (0.80 ± 0.22; p = 0.08). Our study confirmed the correlation between elevated sMUC-1 and high elevated lactate dehydrogenase (p = 0.03) and the level of IgG in groups of patients with MM IgG at every stage of disease (p = 0.001). We showed for the first time that levels of sMUC-1 after treatment, in a group of patients with initially elevated levels of MUC-1, were statistically lower than in a group of patients with initially lower levels of sMUC-1 (21% vs. 42,6%; p = 0.05). At 37 months median of follow-up, we found a statistically significant difference between patients with normal versus elevated sMUC-1 in terms of progression-free survival (median 12 months vs. 8.1 months; p = 0.03).
journal_name
Folia Histochem Cytobioljournal_title
Folia histochemica et cytobiologicaauthors
Lemancewicz D,Bolkun L,Porowska H,Galar M,Semeniuk J,Kloczko J,Dziecioł Jdoi
10.5603/fhc.2011.0089subject
Has Abstractpub_date
2011-01-01 00:00:00pages
654-8issue
4eissn
0239-8508issn
1897-5631journal_volume
49pub_type
杂志文章abstract::The internal space of the antheridium in Chara vulgaris L. is filled with the PAS-positive mucilage which is of pectic nature. Morphometric and cytophotometric measurements on the semithin sections indicate that the concentration and amount of PAS-positive polysaccharides: 1) increase during the time of antheridial gr...
journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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doi:10.2478/v10042-008-0022-7
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abstract::The fibroblast growth factors (FGFs) are multifunctional proteins that, among other roles, regulate structural reorganization of uterine and placental vascular bed during pregnancy. Thus, we analyzed mRNA and protein expression and immunohistochemical localization of FGF-1 and FGF-2, and their receptors (FGFR-1 and FG...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:10.2478/v10042-010-0073-4
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract::CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immuno...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract::We studied the correlation between the cytotoxic effect of hamster peritoneal macrophages from animals bearing transplantable melanomas of common origin but differing in many biological features on the cells of those melanomas and the sensitivity of the melanoma cells to exogenous OSM, TNF-alpha and IL6. Our results d...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::In this study, the histological, immunohistochemical, morphometric, and biochemical changes to pancreatic beta-cells in STZ-induced diabetes were evaluated in rats treated with different doses of caffeine. Fifty adult male Wistar albino rats were divided into five groups: the nondiabetic control group, the diabetic un...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:10.5603/FHC.2014.0005
更新日期:2014-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章,评审
doi:10.2478/v10042-009-0073-4
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The localization of estrogen receptor alpha (ERalpha) in the ovaries of postmenopausal women is a very up-to-date topic in the aspect of using estrogens therapy in the clinical situations of different type. In ovaries of reproductive age women ERalpha is present in ovary stroma, theca and granulosa cells, ovary surfac...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Cancer procoagulant activity in the blood serum of patients with oesophagal, gastric and colorectal cancer was evaluated before and after the tumour removal. Cancer procoagulant activity was significantly higher before the operation in comparison to the control group and was reduced after a total operative procedure, ...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
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