Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.

Abstract:

:The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.

authors

Pancewicz J,Kowalczuk O,Chyczewski L

doi

10.2478/v10042-08-0107-3

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

237-41

issue

2

eissn

0239-8508

issn

1897-5631

pii

P73W15208756N523

journal_volume

48

pub_type

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