Abstract:
:CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans.
journal_name
Folia Histochem Cytobioljournal_title
Folia histochemica et cytobiologicaauthors
Sladowski D,Wasiutyński A,Wilczyński G,Grabska-Liberek I,Coecke S,Kinsner A,Kochanowska Isubject
Has Abstractpub_date
2006-01-01 00:00:00pages
263-7issue
4eissn
0239-8508issn
1897-5631journal_volume
44pub_type
杂志文章abstract::Morphology and some molecular aspects of hyperplastic (bronchial basal cell hyperplasia and alveolar cell hyperplasia), metaplastic (squamous metaplasia), preneoplastic and early neoplastic (dysplasia in squamous metaplasia, cancer in situ and atypical alveolar cell hyperplasia) changes were studied in 180 lungs resec...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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abstract:INTRODUCTION:Aging causes morphological and functional changes in the thyroid gland. Free radicals play a key role in the pathology of normal aging. Vimentin and cytokeratin are cytoskeletal intermediate filaments that are often used as indirect indices of tissue injury. The aim of the study was to clarify the age-rela...
journal_title:Folia histochemica et cytobiologica
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abstract::Very suggestive evidence for possible role of beta-endorphin (BE) in immune activity has been continuously accumulated in the literature in spite of contradictory results about the involvement of the opiate system in immunological response. The reversed passive Arthus reaction (RPAR) was performed in the dorsal area o...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Ghrelin, an appetite-stimulating hormone secreted by the endocrine cells of the gastrointestinal (GI) tract, has recently been shown to affect the function of the cardiovascular system. This study aimed to assess the number and morphology of ghrelin-immunopositive (GhrIP) cells in the gastrointestinal trac...
journal_title:Folia histochemica et cytobiologica
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doi:10.5603/FHC.a2016.0023
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abstract::The effect of cadmium (Cd) on the thyroid and parathyroid glands was examined following a 12-week exposure of rats to 5 or 50 mg Cd/dm3. Immunohistochemical methods were used to determine calcitonin (CT), calcitonin-gene related peptide (GGRP), parathormone (PTH), somatostatin (ST), synaptophysin (SPh) and neuron-spec...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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abstract::Mucins have been shown to be aberrantly overexpressed in various diseases including cystic fibrosis, asthma, and cancer. Recent studies have uncovered the roles of these mucins in the pathogenesis of cancer. The presence of MUC-1 has also been detected on the cell surface of multiple myeloma (MM) cells in peripheral b...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:10.5603/fhc.2011.0089
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abstract::The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment le...
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abstract::The effect of estradiol and progesterone on the noradrenaline (NA) content in nerve fibres of the oviduct, uterus and vagina was investigated in 37 ovariectomized sows, divided into 4 groups. A recovery period was 4 weeks. Starting from the 9th day before killing, the animals were injected 10 times (1 injection/day; t...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::Development of thymic medulla was examined on consecutive gestational days (GD) in Wistar rats. Medullary thymic epithelial cells (TEC) were identified by immunocytochemical localisation of neuron-specific enolase (NSE). Organisation of thymic medullary architecture was determined by interaction of thymocytes with NSE...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
abstract::Primary lung cancer remains the leading cause of cancer death worldwide. Promoter hypermethylation is a major inactivation mechanism of tumor-related genes, and increasingly appears to play an important role in carcinogenesis. In the present study, we used quantitative methylation-specific PCR (Q-MSP) assays to analyz...
journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
abstract::Differentiation of the lingual taste discs (TDs) was studied in tadpoles of Rana esculenta, Hyla arborea and Pelobatesfuscus by means of LM, TEM, and SEM. The process of differentiation of mucous cells (MCs) within a TD anlage was investigated subsequently from 39th to 46th Gosner's developmental stage. In R. esculent...
journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章,评审
doi:10.2478/v10042-010-0033-z
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更新日期:2001-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
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doi:10.2478/v10042-009-0071-6
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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更新日期:2008-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
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更新日期:1985-01-01 00:00:00
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journal_title:Folia histochemica et cytobiologica
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journal_title:Folia histochemica et cytobiologica
pub_type: 杂志文章
doi:
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