Lung recruitment and positive end-expiratory pressure have different effects on CO2 elimination in healthy and sick lungs.

abstract：:Reactive oxygen species (ROS) are central to cardiac ischemic and reperfusion injury. They contribute to myocardial stunning, infarction and apoptosis, and possibly to the genesis of arrhythmias. Multiple laboratory studies and clinical trials have evaluated the use of scavengers of ROS to protect the heart from the e...

journal_title：Anesthesia and analgesia

authors： Kevin LG,Novalija E,Stowe DF

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy. Although the analgesic effect of lidocaine through suppression of microglial activation has been implicated in the development of injury-induced neuropathic pain, its mechanism of action in diabetes-induced tactil...

journal_title：Anesthesia and analgesia

authors： Suzuki N,Hasegawa-Moriyama M,Takahashi Y,Kamikubo Y,Sakurai T,Inada E

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:The use of catheters for continuous nerve blocks has been established in children, although in most series only one catheter was used. We report a case of a 3-yr-old child who underwent a toe-to-finger transfer managed with 2 regional catheters: axillary and sciatic. A pain score of 0 was noted during the en...

journal_title：Anesthesia and analgesia

authors： Dadure C,Acosta C,Capdevila X

更新日期：2004-06-01 00:00:00

abstract：UNLABELLED:General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations. We studied the efficacy of positive end-expiratory pressure (PEEP) application during the induction of general anesthesia (fraction of inspired oxygen [FIO(2)] 1.0) to prevent atelectasis. ...

journal_title：Anesthesia and analgesia

authors： Rusca M,Proietti S,Schnyder P,Frascarolo P,Hedenstierna G,Spahn DR,Magnusson L

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:We implemented a previously described barcode-based drug safety system in all of our anesthetizing locations. Providers were instructed to scan the barcode on syringes using our Anesthesia Information Management System before drug administration, but the rate of provider adherence was low. We studied an impl...

journal_title：Anesthesia and analgesia

authors： Bowdle TA,Jelacic S,Nair B,Zucker F,Bussey LS,Togashi K,Yang JT,Lang J

更新日期：2019-08-01 00:00:00

abstract：:Alkalinized bupivacaine 0.75% (pH 6.8) and a mixture (1:1) of bupivacaine 0.75% and lidocaine 2%, both with hyaluronidase, were compared in regional ophthalmic anesthesia for day-case cataract surgery. Eighty-two patients were randomized into two groups (n = 39 and 43) to receive one of the two solutions in a double-b...

journal_title：Anesthesia and analgesia

authors： Sarvela PJ,Paloheimo MP,Nikki PH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:IV lipid emulsion has demonstrated to be effective therapy for bupivacaine-induced cardiotoxicity. However, the role of epinephrine when coadministered with lipid emulsion in toxin-induced cardiac arrest is unclear. We postulated superior resuscitation outcome in the absence of epinephrine in a rabbit model ...

journal_title：Anesthesia and analgesia

authors： Harvey M,Cave G,Prince G,Lahner D

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:Clonidine decreases the stress-induced sympathoadrenal responses to painful stimuli and improves hemodynamic stability during general anesthesia. Because acute hypertensive responses are often observed immediately after electroconvulsive therapy (ECT), we designed a prospective, randomized, placebo-controlle...

journal_title：Anesthesia and analgesia

authors： Fu W,Stool LA,White PF,Husain MM

更新日期：1998-05-01 00:00:00

abstract：:The effects of commercial and crystalline solutions of chloroprocaine (CP) (1.6 X 10(-3)-0.4 X 10(-3)M) and sodium bisulfite (SB) (0.8 X 10(-3)-0.08 X 10(-3)M) were studied on the multiplication of human neuroblastoma cells. These cells were chosen because of putative neurotoxicity associated with CP; cell multiplicat...

journal_title：Anesthesia and analgesia

authors： Seravalli E,Lear E

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Hyperventilation has been an integral, but poorly validated part of neuroanesthetic practice. We conducted a two-period, crossover, randomized trial to evaluate surgeon-assessed brain bulk and measured intracranial pressure (ICP) in patients undergoing craniotomy for removal of supratentorial brain tumors du...

journal_title：Anesthesia and analgesia

authors： Gelb AW,Craen RA,Rao GS,Reddy KR,Megyesi J,Mohanty B,Dash HH,Choi KC,Chan MT

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Previous modeling of the kinetics of uptake and elimination of anesthetic drugs from the site of action has used measures derived from the electroencephalogram. Such measures lag the current brain activity because of the time needed to acquire a signal sample and derive the measure. With a direct measure of ...

journal_title：Anesthesia and analgesia

authors： Drummond GB,Bleach L,Thomson AJ,Kennedy RR

更新日期：2012-09-01 00:00:00

abstract：:The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research, established by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership with the US Food and Drug Administration, convened a meeting of sedation e...

journal_title：Anesthesia and analgesia

authors： Williams MR,Ward DS,Carlson D,Cravero J,Dexter F,Lightdale JR,Mason KP,Miner J,Vargo JJ,Berkenbosch JW,Clark RM,Constant I,Dionne R,Dworkin RH,Gozal D,Grayzel D,Irwin MG,Lerman J,O'Connor RE,Pandharipande P,Rappap

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The therapeutic use of opioids has been associated with altered cognition and impaired psychomotor function. Several studies have demonstrated the impact of opioid therapy on psychomotor performance and cognition, but there are no data about the effect of long-term treatment with transdermal buprenorphine on...

journal_title：Anesthesia and analgesia

authors： Dagtekin O,Gerbershagen HJ,Wagner W,Petzke F,Radbruch L,Sabatowski R

更新日期：2007-11-01 00:00:00

abstract：:This study was undertaken to compare the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics injected by lumbar puncture in the mouse and rat. Antinociception was determined by observing the response to a clamp applied to the tail (Haffner te...

journal_title：Anesthesia and analgesia

authors： Ossipov MH,Suarez LJ,Spaulding TC

更新日期：1988-07-01 00:00:00

abstract：:The existence of a dose-response relation between nitrous oxide concentration and regional dysfunction in compromised myocardium, and whether or not halothane-induced myocardial depression alleviated this regional dysfunction was examined. Nitrous oxide was administered to eight dogs with experimentally induced left a...

journal_title：Anesthesia and analgesia

authors： Leone BJ,Philbin DM,Lehot JJ,Foëx P,Ryder WA

更新日期：1988-09-01 00:00:00

abstract：:Several observational and objective methods are available to assess sedation depth; however, data regarding their accuracy in differentiating deep sedation are limited. In this study we compared 3 sedation tools in children from birth to 18 yr of age and determined their relative value in detecting deep levels of seda...

journal_title：Anesthesia and analgesia

authors： Malviya S,Voepel-Lewis T,Tait AR

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar (i.pl.) injection of hypertonic saline (HS) in mice produces robust nociceptive re...

journal_title：Anesthesia and analgesia

authors： Asiri YI,Fung T,Schwarz SKW,Barr AM,Puil E,MacLeod BA

更新日期：2019-07-01 00:00:00

abstract：:Attempted pulmonary artery catheterization via the left internal jugular vein resulted in a misdiagnosis of pulmonary hypertension before transesophageal echocardiography revealed the catheter positioned in the ascending aorta. Inadvertent aortic cannulation through an unusual type of partial anomalous pulmonary venou...

journal_title：Anesthesia and analgesia

authors： Siegmueller C,Bell A,Mittal T,George S

更新日期：2008-01-01 00:00:00

abstract：:Inferential statistics relies heavily on the central limit theorem and the related law of large numbers. According to the central limit theorem, regardless of the distribution of the source population, a sample estimate of that population will have a normal distribution, but only if the sample is large enough. The rel...

journal_title：Anesthesia and analgesia

authors： Mascha EJ,Vetter TR

更新日期：2018-02-01 00:00:00

abstract：:Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for pro...

journal_title：Anesthesia and analgesia

authors： Mirzakhani H,Nozari A,Ehrenfeld JM,Peterfreund R,Szabo M,Walsh JL,Jiang Y,Sandberg W,Rosow C,Wang J

更新日期：2013-07-01 00:00:00

abstract：UNLABELLED:We constructed a single-dose response curve for succinylcholine in 30 obese adolescents during thiopental-fentanyl anesthesia administration by using 100 microg/kg, 150 microg/kg, or 250 microg/kg IV. The maximal response (percent depression of neuromuscular function) of the adductor pollicis to supramaximal...

journal_title：Anesthesia and analgesia

authors： Rose JB,Theroux MC,Katz MS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Xenon anesthesia has been studied for decades. However, no meta-analysis of randomized controlled trials (RCTs) on xenon anesthesia has been conducted. The aim of this study was to systematically review all available evidence from RCTs comparing xenon and other inhaled and IV anesthetics on anesthetic outcom...

journal_title：Anesthesia and analgesia

authors： Law LS,Lo EA,Gan TJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:This study investigated the clinical performance of a model-based, patient-individualized closed-loop (CL) control system for propofol administration using the bispectral index (BIS) as a controlled variable during the induction and maintenance of anesthesia with propofol and remifentanil and studied the inf...

journal_title：Anesthesia and analgesia

authors： Neckebroek M,Boldingh JHL,De Smet T,Struys MMRF

更新日期：2020-06-01 00:00:00

abstract：UNLABELLED:We compared the efficacy of gas exchange during supraglottic combined-frequency jet ventilation via a jet ventilation laryngoscope and during monofrequent jet ventilation via the Mon-Jet catheter (Xomed, Jacksonville, FL). Twenty-three anesthetized (propofol, fentanyl, vecuronium) patients undergoing microla...

journal_title：Anesthesia and analgesia

authors： Bacher A,Pichler K,Aloy A

更新日期：2000-02-01 00:00:00

abstract：:We investigated the incidence of transient neurologic symptoms (TNS) after the use of hyperbaric lidocaine as compared with hyperbaric bupivacaine in patients undergoing cesarean delivery under spinal anesthesia. Two hundred women scheduled for cesarean delivery were randomly allocated to receive spinal anesthesia wit...

journal_title：Anesthesia and analgesia

authors： Aouad MT,Siddik SS,Jalbout MI,Baraka AS

更新日期：2001-02-01 00:00:00

abstract：:Previous studies have shown that bolus doses of fentanyl (50 and 100 micrograms) with epidural bupivacaine delay gastric emptying by up to 45 min. We studied the effect of the addition of small-dose fentanyl to epidural bupivacaine infusions on gastric emptying during labor. The acetaminophen absorption technique was ...

journal_title：Anesthesia and analgesia

authors： Zimmermann DL,Breen TW,Fick G

更新日期：1996-03-01 00:00:00

abstract：:Previous in vivo studies of the coronary vascular effects of halothane (HAL) were complicated by varying hemodynamic conditions and global cardiac work demands. Accordingly, the current study evaluated changes in coronary blood flow (CBF) and associated variables during selective intracoronary administrations of HAL i...

journal_title：Anesthesia and analgesia

authors： Crystal GJ,Khoury E,Gurevicius J,Salem MR

更新日期：1995-02-01 00:00:00

abstract：:Procaine hydrochloride was added to cardioplegia and studied for its efficacy in stabilizing the postischemic rhythm after aortic declamping in cardiac surgery. Fifty-six patients scheduled for coronary artery bypass grafting (CABG), were included in a randomized, double-blind study. The patients were anesthetized wit...

journal_title：Anesthesia and analgesia

authors： Sellevold OF,Berg EM,Levang OW

更新日期：1995-11-01 00:00:00

abstract：:Sufentanil is a new synthetic opiate analgesic that is 4520 times more potent than morphine in animal experiments. This study evaluated the cardiovascular effects of sufentanil, 15 micrograms/kg, and air/O2 used as a complete anesthetic with 50% inspired oxygen (air/O2 mixture) in 40 adult patients undergoing elective...

journal_title：Anesthesia and analgesia

authors： Sebel PS,Bovil JG

更新日期：1982-02-01 00:00:00

abstract：:Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone on platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmon...

journal_title：Anesthesia and analgesia

authors： Kikura M,Lee MK,Safon RA,Bailey JM,Levy JH

更新日期：1995-07-01 00:00:00