Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin.

Abstract:

:Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery. In a retrospective case-control study of 75 patients, we confirmed this potentially serious drug-drug interaction. After rifampin, there was a significant and prolonged arterial blood pressure reduction when patients received propofol, but not thiopental.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Mirzakhani H,Nozari A,Ehrenfeld JM,Peterfreund R,Szabo M,Walsh JL,Jiang Y,Sandberg W,Rosow C,Wang J

doi

10.1213/ANE.0b013e318292cbd0

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

61-4

issue

1

eissn

0003-2999

issn

1526-7598

pii

ANE.0b013e318292cbd0

journal_volume

117

pub_type

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