Blood Substitutes and Oxygen Therapeutics: A Review.

Abstract:

:Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood transfusion is not an option, due to patient's religious beliefs, inability to find adequately cross-matched erythrocytes, or in remote locations. In these situations, artificial oxygen carriers may provide a mortality benefit for patients with severe, life-threatening anemia. This article provides an up-to-date review of the history and development, clinical trials, new technology, and current standing of artificial oxygen carriers as an alternative to transfusion when blood is not an option.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Jahr JS,Guinn NR,Lowery DR,Shore-Lesserson L,Shander A

doi

10.1213/ANE.0000000000003957

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

119-129

issue

1

eissn

0003-2999

issn

1526-7598

pii

00000539-202101000-00020

journal_volume

132

pub_type

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