Cytokine networks in multiple sclerosis: lost in translation.

abstract：PURPOSE OF REVIEW:There is an urgent need for effective therapies to restore neurologic function and decrease disability following traumatic brain injury (TBI). Here, emerging findings on the mechanisms of post-TBI neural repair and regeneration, as well as therapeutic implications, are selectively reviewed. RECENT FI...

journal_title：Current opinion in neurology

authors： Werner JK,Stevens RD

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the new terms and concepts proposed by the International League Against Epilepsy (ILAE) Classification Commission in 2010 to describe seizures and epilepsies. This is the first major revision in 21 years and reflects the rapid evolution in our understanding of the epilepsies. REC...

journal_title：Current opinion in neurology

authors： Korff CM,Scheffer IE

更新日期：2013-04-01 00:00:00

abstract：:The ability to recognize elements of the environment as familiar objects, events, or classes underlies virtually all human cognition. Positron emission tomography and functional magnetic resonance imaging studies of the recognition of visually presented objects suggest that several brain areas crucially support this f...

journal_title：Current opinion in neurology

authors： Bly BM,Kosslyn SM

更新日期：1997-02-01 00:00:00

abstract：:This review centers on important recent advances in the understanding of the role of glial fibrillary acidic protein in Alexander disease and of proteolipid protein in hypomyelinating disorders such as Pelizaeus-Merzbacher and spastic paraplegia. We also describe seven novel leukodystrophies. These include childhood a...

journal_title：Current opinion in neurology

authors： Schiffmann R,Boespflüg-Tanguy O

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

journal_title：Current opinion in neurology

authors： Gallo V,Armstrong RC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cerebral amyloid angiopathy (CAA) is diagnosed primarily as a cause of lobar intracerebral hemorrhages (ICH) in elderly patients. With improving MRI techniques, however, the role of CAA in causing other symptoms has become clear. Recognizing the full clinical spectrum of CAA is important for diagnosis...

journal_title：Current opinion in neurology

authors： Wermer MJH,Greenberg SM

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

journal_title：Current opinion in neurology

authors： Bromley RL,Baker GA,Meador KJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The traditional focus of neurorehabilitaion has been on the patients' attention on their deficit, such that they should become aware of their problems and gain intentional control of compensatory strategies (descending approach). We review prism adaptation as one of the approaches that emphasize ascen...

journal_title：Current opinion in neurology

authors： Pisella L,Rode G,Farnè A,Tilikete C,Rossetti Y

更新日期：2006-12-01 00:00:00

abstract：:New reports of the incidence, prevalence and mortality of Parkinson's disease and parkinsonism are reviewed. Evidence for occupational and lifestyle risk factors and protective factors is updated. Recent genetic epidemiology studies of parkinsonism in twins and families, and studies that investigated imaging and physi...

journal_title：Current opinion in neurology

authors： Tanner CM,Aston DA

更新日期：2000-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Valproic acid (VPA) is one of the four first line antiepileptic drugs (AEDs). VPA is also an effective drug in migraine prophylaxis and in treatment of bipolar disorders. The use of VPA is limited by its two rare but potentially life-threatening side effects, teratogenicity and hepatotoxicity, and it ...

journal_title：Current opinion in neurology

authors： Isoherranen N,Yagen B,Bialer M

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to refer to recent arguments supporting the existence of specific propagation mechanisms associated with spreading of neuron injury in amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:Misfolded ALS-linked protein accumulation can induce aggregation of their native equiva...

journal_title：Current opinion in neurology

authors： Pradat PF,Kabashi E,Desnuelle C

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize advances in our understanding of the clinical phenotypes, genetics, and molecular pathophysiology of the periodic paralyses, the nondystrophic myotonias, and other muscle channelopathies. RECENT FINDINGS:The number of pathogenic mutations causing periodic paralysis, nondystrophic myotoni...

journal_title：Current opinion in neurology

authors： Platt D,Griggs R

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent advances in survival for patients with newly diagnosed and recurrent brain tumors, combined with the development of an ever-increasing number of potential treatments, has led to significant growth in the number of clinical trials for patients with brain tumors. Suitable clinical trial design an...

journal_title：Current opinion in neurology

authors： Butowski N,Chang SM

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The search for a cure for Duchenne muscular dystrophy and other muscular dystrophies is progressing rapidly despite significant challenges posed by some genes and the complexity of targeting all skeletal muscles. This review focuses on three areas in which experimental clinical studies are in progress...

journal_title：Current opinion in neurology

authors： Muntoni F,Wells D

更新日期：2007-10-01 00:00:00

abstract：:Although reactive oxygen species are natural metabolic products, they can be toxic to cells and are implicated in some neurodegenerative disease. Cytosolic Cu, Zn superoxide dismutase normally defends against damage by reactive oxygen species; however, mutant forms of the enzyme might instead contribute to damage of m...

journal_title：Current opinion in neurology

authors： Hosler BA,Brown RH Jr

更新日期：1996-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent years have witnessed the discoveries of several genes causing neurodegeneration with brain iron accumulation (NBIA) and subsequently their novel classification scheme was suggested. The first results of treatments with modern chelating drugs are also being published. RECENT FINDINGS:Most recen...

journal_title：Current opinion in neurology

authors： Dusek P,Schneider SA

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the pathogenesis, clinical presentation, course, and therapy of herpes simplex encephalitis (HSE), the most fatal viral encephalitis, in which prognosis is dependent on early diagnosis and effective therapy. RECENT FINDINGS:Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) ...

journal_title：Current opinion in neurology

authors： Steiner I

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS:Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms precedin...

journal_title：Current opinion in neurology

authors： Mula M

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

journal_title：Current opinion in neurology

authors： Ai S,Klein RS

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To give an overview of recent data on the use of skin biopsy as a diagnostic tool in neuropathies. RECENT FINDINGS:The sensitivity and specificity of skin biopsy in detecting small fiber neuropathy is supported by new data. In many patients with small fiber neuropathy, a treatable disorder can be ide...

journal_title：Current opinion in neurology

authors： Sommer C

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intens...

journal_title：Current opinion in neurology

authors： Cimbalnik J,Kucewicz MT,Worrell G

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To gain a complete understanding of how the brain functions, both in illness and good health, data from multiple levels of analysis must be integrated. Technical advances have made direct recordings of neuronal activity deep inside the human brain tractable, providing a rare glimpse into cellular proc...

journal_title：Current opinion in neurology

authors： Viskontas IV

更新日期：2008-12-01 00:00:00

abstract：:This paper reviews current knowledge about epileptogenesis in the developing brain. Animal studies indicate that the maturational balance of excitatory and inhibitory neurotransmitter systems should result in an increased susceptibility to seizures. However, the reason for specific age-locked syndromes and the high ra...

journal_title：Current opinion in neurology

authors： Scott RC,Neville BG

更新日期：1998-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments. RECENT FINDINGS:The findings suggest that attention deficit-hyperactivity disorder is characterized by specific learning and c...

journal_title：Current opinion in neurology

authors： Casey BJ,Nigg JT,Durston S

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperglycemia is frequent in patients with cerebrovascular disease. This review article aims to summarize the recent evidence from observational studies that examined the adverse cerebrovascular effects of dysglycemic states as well as interventional studies assessing intensive management strategies f...

journal_title：Current opinion in neurology

authors： Haratz S,Tanne D

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:New insights into the psychophysiological determinants of performance changes and brain plasticity associated with motor sequence learning have recently been gained through behavioral and imaging studies in healthy individuals. In addition, using a variety of motor sequential paradigms in groups of pa...

journal_title：Current opinion in neurology

authors： Doyon J

更新日期：2008-08-01 00:00:00

abstract：:Stimulated by the impressive effect of interferon beta on magnetic resonance imaging-detected disease activity, the past year or so has seen a particular interest in the use of magnetic resonance imaging to monitor treatment. To be effective in this regard, there needs to be a high sensitivity and accuracy in detectin...

journal_title：Current opinion in neurology

authors： Miller DH

更新日期：1995-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The trigeminal autonomic reflex is a physiological reflex with an important protective function which also plays a role in pathophysiological conditions, such as primary headache. It is not understood whether the autonomic symptoms in trigeminal autonomic cephalalgias and migraine are the consequence ...

journal_title：Current opinion in neurology

authors： Möller M,May A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the results of recent therapeutic trials in dermatomyositis, polymyositis, and inclusion body myositis and suggests an approach to treating patients with inflammatory myopathy. RECENT FINDINGS:We reviewed 10 double-blind, placebo-controlled therapeutic trials in patients with inf...

journal_title：Current opinion in neurology

authors： Amato AA,Griggs RC

更新日期：2003-10-01 00:00:00

abstract：:Although theoretical reasons exist for believing that selegiline slows the progression of Parkinson's disease, this has not been shown in clinical trials. Selegiline improves the symptoms of Parkinson's disease, allowing the introduction of levodopa to be delayed in de-novo patients and, later, for levodopa to be used...

journal_title：Current opinion in neurology

authors： Hely MA,Morris JG

更新日期：1996-08-01 00:00:00