Abstract:
PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regarding the possible cognitive and behavioural impact of exposure to antiepileptic drugs in utero. RECENT FINDINGS:Recent evidence from large prospective cohorts indicates that there is a longer term risk to the cognitive and behavioural development of the child exposed in utero to sodium valproate. Information on other antiepileptic agents is conflicting or nonexistent and more research in this area is urgently required. SUMMARY:Despite the methodological shortfalls of some of the research in this area, there is an accumulation of evidence highlighting an increased risk for cognitive and behavioural difficulties in children exposed to sodium valproate in utero. Although less certain, there may also be risks associated with phenobarbital and phenytoin exposure. Information regarding these risks should be communicated to the potential mother who has epilepsy.
journal_name
Curr Opin Neuroljournal_title
Current opinion in neurologyauthors
Bromley RL,Baker GA,Meador KJdoi
10.1097/WCO.0b013e3283292401subject
Has Abstractpub_date
2009-04-01 00:00:00pages
162-6issue
2eissn
1350-7540issn
1473-6551pii
00019052-200904000-00009journal_volume
22pub_type
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000571
更新日期:2018-08-01 00:00:00
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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doi:10.1097/wco.0b013e32832b4c62
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abstract::Little progress has been made in the treatment outcome of patients with glioblastoma in the past 10 to 15 years, despite an aggressive multimodality regimen using surgery, radiation, and chemotherapy. New approaches, particularly molecular strategies, have become the clinicians' and scientists' hope for the future in ...
journal_title:Current opinion in neurology
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abstract::Neuropharmacology is aiding our understanding of the control of eye movements in at least three ways. First, neurotransmitters have been identified in the pathways that coordinate gaze. Second, the technique of pharmacologic inactivation has provided a powerful method to determine the contributions of populations of n...
journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199906000-00003
更新日期:1999-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The aims of this article are to review emerging therapies for multiple sclerosis (MS) and to consider new approaches to assessment and achievement of treatment success in patients with this disease. RECENT FINDINGS:A number of disease-modifying therapies for MS, including oral agents, are in advanced...
journal_title:Current opinion in neurology
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doi:10.1097/01.wco.0000413320.94715.e9
更新日期:2012-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. RECENT FINDINGS:Recent twin studies have confirmed that NDDs show moderate-to-hi...
journal_title:Current opinion in neurology
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doi:10.1097/WCO.0b013e32835f19c3
更新日期:2013-04-01 00:00:00
abstract::Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurology
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更新日期:2007-06-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurology
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更新日期:2011-06-01 00:00:00