Diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy using MRI.

abstract：PURPOSE OF REVIEW:The last 5 years have seen the number of ultra-high field (UHF; 7 T and beyond) MRI scanners nearly double. Benefits include improved specificity, better sensitivity for signal-starved compounds, and the ability to detect, quantify, and monitor tumor activity and treatment effects. This is especially ...

journal_title：Current opinion in neurology

authors： Lupo JM,Li Y,Hess CP,Nelson SJ

更新日期：2011-12-01 00:00:00

abstract：:Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to ...

journal_title：Current opinion in neurology

authors： Voisin T,Touchon J,Vellas B

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pa...

journal_title：Current opinion in neurology

authors： Gilhus NE

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes key findings of the current literature on functional neuroimaging in migraine and describes how these studies have changed our view of the disorder. RECENT FINDINGS:Recent studies have started not only to investigate the global cerebral activation pattern during migraine attack...

journal_title：Current opinion in neurology

authors： Sprenger T,Borsook D

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human traumatic brain injury (TBI) and stroke, along with preclinical findings of a persistent hypofunctional state of these receptors after brain injury, resulted in a new focus on NMDAR agonists, specifically those a...

journal_title：Current opinion in neurology

authors： Biegon A,Liraz-Zaltsman S,Shohami E

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the major recent developments in understanding of pathogenic mechanisms in inflammatory and paraproteinaemic neuropathies. RECENT FINDINGS:In the inflammatory neuropathies, there has been a particular focus on antibody-mediated disease affecting the nodal/paranodal regions. Dis...

journal_title：Current opinion in neurology

authors： Rinaldi S,Bennett DL

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Our current treatment algorithms include only IFN-β and glatiramer as available first-line disease-modifying drugs and natalizumab and fingolimod as second-line therapies. Today, 10 drugs have been approved in Europe and nine in the United States making the choice of therapy more complex. The purpose ...

journal_title：Current opinion in neurology

authors： Sorensen PS

更新日期：2014-06-01 00:00:00

abstract：:Positron emission tomography, single photon emission computed tomography and magnetic resonance spectroscopy provide distinct, uncorrelated and sensitive indicators of brain tumors which can be used to improve differential diagnosis, biopsy guidance or therapy monitoring. New findings, including conflicting ethyl-cyst...

journal_title：Current opinion in neurology

authors： Slosman DO,Lazeyras F

更新日期：1996-12-01 00:00:00

abstract：:Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...

journal_title：Current opinion in neurology

authors： Biering-Sørensen F,Hartkopp A

更新日期：1995-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss aspects of cytokine networks in neuroinflammatory diseases and attempt to provide some explanation for our failures and successes in translating preclinical data to benefit patients with multiple sclerosis (MS). We will discuss innate cytokines such as tumor necrosis factor al...

journal_title：Current opinion in neurology

authors： Codarri L,Fontana A,Becher B

更新日期：2010-06-01 00:00:00

abstract：:A review of the literature on methods of seizure or epilepsy severity assessments resulted in tabulation of the seizure rating scales known as US Department of Veterans Affairs (VA), Chalfont-National Hospital, Liverpool, Hague, and others. Each of the scales reviewed has some advantages, but none of them appears to b...

journal_title：Current opinion in neurology

authors： Cramer JA

更新日期：2001-04-01 00:00:00

abstract：:Although spreading depression has been known for over 50 years, recent research into this interesting experimental phenomenon provides evidence for an integrative role of spreading depression in brain pathophysiology. Spreading depression activates neurophysiological pathways that may have widespread consequences on b...

journal_title：Current opinion in neurology

authors： Parsons AA

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the current literature on endovascular treatment of acute ischemic stroke in the aftermath of the coronavirus disease 2019 (COVID-19) lockdown. RECENT FINDINGS:The outbreak of the COVID-19 has had effect of unprecedented magnitude on the social, economic and perso...

journal_title：Current opinion in neurology

authors： Dobrocky T,Kaesmacher J,Pereira VM,Gralla J,Fischer U

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The search for a cure for Duchenne muscular dystrophy and other muscular dystrophies is progressing rapidly despite significant challenges posed by some genes and the complexity of targeting all skeletal muscles. This review focuses on three areas in which experimental clinical studies are in progress...

journal_title：Current opinion in neurology

authors： Muntoni F,Wells D

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on our knowledge regarding prevention and management of medication overuse headache (MOH). RECENT FINDINGS:The prevalence of MOH is 1-2% in the general population worldwide, and because of the tremendous socio-economic cost, it is likely to be the most costly neurologic...

journal_title：Current opinion in neurology

authors： Russell MB,Lundqvist C

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Gliomas represent a disparate group of malignancies with varying clinical outcomes despite a tremendous amount of time, effort, and resources dedicated to their management and understanding. The most aggressive entity, glioblastoma, has a dismal prognosis with poor local control despite intense local ...

journal_title：Current opinion in neurology

authors： Beckta JM,Bindra RS,Chalmers AJ

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of epilepsy and seizure disorders caused by autoantibodies to specific neuronal membrane proteins has developed significantly during the past few years. RECENT FINDINGS:Antibodies to cell-surface membrane proteins such as voltage-gated potassium channels or N-methyl-D-aspartate receptors,...

journal_title：Current opinion in neurology

authors： Vincent A,Irani SR,Lang B

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cervical spondylotic myelopathy (CSM) is a potentially debilitating disorder primarily related to spinal cord injury caused by degenerative changes of the spine. As the population continues to age and live longer, it is likely that this disorder will be encountered with increasing frequency. RECENT F...

journal_title：Current opinion in neurology

authors： Holly LT

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Trigeminal autonomic cephalgias (TACs) are characterized by frequent, short-lasting headache attacks with ipsilateral facial autonomic features. They include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. The...

journal_title：Current opinion in neurology

authors： Wilbrink LA,Ferrari MD,Kruit MC,Haan J

更新日期：2009-06-01 00:00:00

abstract：:A long series of studies beginning with the pioneering experiments of Wiesel and Hubel [1] has shown that correct visual experience is crucial for the development of the visual system. Recent results suggest that neurotrophic factors of the nerve growth factor family might have a relevant role in mediating the effects...

journal_title：Current opinion in neurology

authors： Pizzorusso T,Maffei L

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review on traumatic brain injury consolidates the substantial current literature available on the pathophysiology, mechanisms, developments, and their subsequent effects on outcome. In particular, it tries to conceptualize why our greatly improved understanding of pathophysiology and neurobiology...

journal_title：Current opinion in neurology

authors： Nortje J,Menon DK

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cervical artery dissection (CeAD) is a major cause of ischemic stroke in young and middle-aged adults, although relatively uncommon in the community. Recent large collaborative projects have provided new insights into mechanisms and risk factors of CeAD. RECENT FINDINGS:Pathologic changes observed at...

journal_title：Current opinion in neurology

authors： Debette S

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to systematically and critically review the relationship between migraine and estrogen, the predominant female sex hormone, with a focus on studies published in the last 18 months. RECENT FINDINGS:Recent functional MRI (fMRI) studies of the brain support the existence of anatomical and fun...

journal_title：Current opinion in neurology

authors： Chai NC,Peterlin BL,Calhoun AH

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses current data on nosological boundaries related to diagnosis, pathophysiology and therapeutic strategies in chronic tension-type headache (CTTH). RECENT FINDINGS:Diagnostic criteria of CTTH should be adapted to improve its sensitivity against migraine. It seems that mechanical pa...

journal_title：Current opinion in neurology

authors： Fernández-de-las-Peñas C,Schoenen J

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic discovery has been extremely rapid over the last year, with many new discoveries illuminating novel mechanisms and pathways. In particular, the application of whole exome and whole genome sequencing has identified many new genetic causes of the epilepsies. As such methods become increasingly a...

journal_title：Current opinion in neurology

authors： Sisodiya SM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:After more than 10 years of methodological developments and clinical applications, diffusion imaging tractography has reached a crossroad. Although the method is still in its infancy, the time has come to address some important questions. Can tractography reproduce reliably known anatomy or describe n...

journal_title：Current opinion in neurology

authors： Dell'Acqua F,Catani M

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS:Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms precedin...

journal_title：Current opinion in neurology

authors： Mula M

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to refer to recent arguments supporting the existence of specific propagation mechanisms associated with spreading of neuron injury in amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:Misfolded ALS-linked protein accumulation can induce aggregation of their native equiva...

journal_title：Current opinion in neurology

authors： Pradat PF,Kabashi E,Desnuelle C

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent advances in cochlear gene therapy over the past several years. Cochlear gene therapy has undergone tremendous advances over the past decade. Beginning with some groundbreaking work in 2005 documenting hair cell regeneration using virally mediated delivery of the mouse ato...

journal_title：Current opinion in neurology

authors： Lustig LR,Akil O

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Migraine has traditionally been categorized as a pain disorder, focusing on headache as its central feature. This narrow view does not account for the complex array of premonitory and postrdromal symptoms that occur in the hours before and after headache. This review outlines evidence that supports a ...

journal_title：Current opinion in neurology

authors： Charles A

更新日期：2013-06-01 00:00:00