Migraine: a brain state.


PURPOSE OF REVIEW:Migraine has traditionally been categorized as a pain disorder, focusing on headache as its central feature. This narrow view does not account for the complex array of premonitory and postrdromal symptoms that occur in the hours before and after headache. This review outlines evidence that supports a broader view of migraine as a pathological brain state. RECENT FINDINGS:Studies of the clinical features of a migraine attack, in combination with imaging and electrophysiological studies, provide evidence that migraine involves widespread changes in brain function and connectivity. These changes parallel those seen in other brain states such as sleep. Neurochemical mediators, including adenosine, and nonsynaptic signalling mechanisms involving astrocytes may play a role in the migraine state. SUMMARY:Consideration of a migraine attack as a brain state provides an expanded framework for understanding all of its symptoms, and the underlying alterations in the activity of multiple brain networks. Mechanisms driving the transition to the migraine state may represent novel targets for acute and preventive therapies.


Curr Opin Neurol


Charles A




Has Abstract


2013-06-01 00:00:00












  • Depression in epilepsy.

    abstract:PURPOSE OF REVIEW:To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS:Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms precedin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Mula M

    更新日期:2017-04-01 00:00:00

  • Neurosteroids and epilepsy.

    abstract:PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Biagini G,Panuccio G,Avoli M

    更新日期:2010-04-01 00:00:00

  • Prevention and management of adverse effects of disease modifying treatments in multiple sclerosis.

    abstract:PURPOSE OF REVIEW:To summarize the currently known side effects of the approved therapies of multiple sclerosis and to suggest monitoring procedures. RECENT FINDINGS:The progress in the treatment of multiple sclerosis with new very effective therapies is accompanied by a number of side effects. Some of these have alre...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Moiola L,Rommer PS,Zettl UK

    更新日期:2020-06-01 00:00:00

  • Maintaining high thrombectomy rates during pandemics.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review the current literature on endovascular treatment of acute ischemic stroke in the aftermath of the coronavirus disease 2019 (COVID-19) lockdown. RECENT FINDINGS:The outbreak of the COVID-19 has had effect of unprecedented magnitude on the social, economic and perso...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Dobrocky T,Kaesmacher J,Pereira VM,Gralla J,Fischer U

    更新日期:2021-02-01 00:00:00

  • Are high-frequency oscillations better biomarkers of the epileptogenic zone than spikes?

    abstract:PURPOSE OF REVIEW:Precise localization of the epileptogenic zone is imperative for the success of resective surgery of drug-resistant epileptic patients. To decrease the number of surgical failures, clinical research has been focusing on finding new biomarkers. For the past decades, high-frequency oscillations (HFOs, 8...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Roehri N,Bartolomei F

    更新日期:2019-04-01 00:00:00

  • Emery-Dreifuss muscular dystrophy: focal point nuclear envelope.

    abstract:PURPOSE OF REVIEW:Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in EMD encoding emerin and LMNA encoding A-type lamins, proteins of the nuclear envelope. In the past decade, there has been an extraordinary burst of research on the nuclear envelope. Discoveries resulting from this basic research have i...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Muchir A,Worman HJ

    更新日期:2019-10-01 00:00:00

  • Update on T cells in the virally infected brain: friends and foes.

    abstract:PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Ai S,Klein RS

    更新日期:2020-06-01 00:00:00

  • Thrombolysis for acute stroke.

    abstract:PURPOSE OF REVIEW:Stroke thrombolysis is in the process of moving from academic centers into community-based standard therapy in experienced centers. Recently published data on patient selection, imaging and other technical or organizational advances are reviewed in order to improve the safety and efficacy of stroke th...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Lindsberg PJ,Kaste M

    更新日期:2003-02-01 00:00:00

  • Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero.

    abstract:PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Bromley RL,Baker GA,Meador KJ

    更新日期:2009-04-01 00:00:00

  • Primary and secondary ataxias.

    abstract:PURPOSE OF REVIEW:This article discusses recent advances in the understanding of clinical and genetic aspects of primary ataxias, including congenital, autosomal recessive, autosomal dominant, episodic, X-linked, and mitochondrial ataxias, as well as idiopathic degenerative and secondary ataxias. RECENT FINDINGS:Many ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Teive HA,Ashizawa T

    更新日期:2015-08-01 00:00:00

  • Multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculoneuropathy.

    abstract::In multifocal motor or sensorimotor neuropathy with persistent conduction block, most of the recent research has concerned treatment. Open trials show that intravenous immunoglobulin is effective, providing a rapid and often marked clinical improvement, accompanied by a significant reduction of conduction block in som...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Léger JM

    更新日期:1995-10-01 00:00:00

  • Learning and memory: recent findings.

    abstract::Recent findings from neuroimaging, event-related potential and lesion investigations reflect a rapidly emerging view that the memory system is widely distributed throughout the cortex. It is clear that the pattern of cortical involvement during encoding and retrieval of memories is critically dependent on the nature a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Bright P,Kopelman MD

    更新日期:2001-08-01 00:00:00

  • Mild cognitive impairment: a nosological entity?

    abstract::Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Voisin T,Touchon J,Vellas B

    更新日期:2003-12-01 00:00:00

  • Molecular genetic aspects of the phakomatoses: tuberous sclerosis complex and neurofibromatosis 1.

    abstract::The phakomatoses are a diverse group of diseases characterized by skin lesions in early childhood followed by the development of tumors in many other organs. Tuberous sclerosis complex and neurofibromatosis 1 are of special interest to the neurologist because of their prominent neuro-oncological and neuro-developmenta...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: MacCollin M,Kwiatkowski D

    更新日期:2001-04-01 00:00:00

  • Desmin-related myopathies.

    abstract::Desmin-related myopathies are marked by accumulation of desmin, which is often familial and associated with cardiomyopathy. When multifocal this excess is characterized by inclusions such as cytoplasmic or spheroid bodies, when disseminated the excess is called granulofilamentous material. Excess of desmin might repre...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Goebel HH

    更新日期:1997-10-01 00:00:00

  • Longitudinal imaging: change and causality.

    abstract:PURPOSE OF REVIEW:Longitudinal studies that use MRI scans performed over multiple time-points have been increasingly employed in the study of different neurological disorders, including degenerative dementia, multiple sclerosis, and epilepsy. RECENT FINDINGS:Although it is well established that increased rates of brai...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Whitwell JL

    更新日期:2008-08-01 00:00:00

  • Approaches permitting and enhancing motoneuron regeneration after spinal cord, ventral root, plexus and peripheral nerve injuries.

    abstract::The motoneuron has a strong ability to regenerate after injury. However, the problems of nerve cell survival after a proximal axotomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity during nerve fibre regrowth interfere with a good functional restitution. Current research h...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Carlstedt T

    更新日期:2000-12-01 00:00:00

  • Skeletal muscle sodium channelopathies.

    abstract:PURPOSE OF REVIEW:This is an update on skeletal muscle sodium channelopathies since knowledge in the field have dramatically increased in the past years. RECENT FINDING:The relationship between two phenotypes and SCN4A has been confirmed with additional cases that remain extremely rare: severe neonatal episodic laryng...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Nicole S,Fontaine B

    更新日期:2015-10-01 00:00:00

  • Rasmussen's syndrome.

    abstract::Subacute focal encephalitis of Rasmussen involves cortical inflammatory infiltration which may on occasion be bilateral. The presence of anti-Glu R3 antibodies in some patients suggests that an autoimmune process may be involved. Although a small number of patients respond transiently to immunoglobulins and the condit...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章


    authors: Dulac O

    更新日期:1996-04-01 00:00:00

  • Magnetic resonance spectroscopy in toxic encephalopathy and neurodegeneration.

    abstract::Magnetic resonance spectroscopy allows neurochemistry to be probed noninvasively in vivo. Recent advances in our understanding of the biochemical significance of the various neurochemicals that are observable allow a variety of pathologic states of relevance to encephalopathies and neurodegenerative disorders to be ob...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Jenkins BG,Kraft E

    更新日期:1999-12-01 00:00:00

  • Neurologic complications of immune checkpoint inhibitors.

    abstract:PURPOSE OF REVIEW:In recent years, advances in the understanding of the regulatory mechanisms of the immune system has led to the development of new approaches for cancer treatment. Currently, immune checkpoint inhibitors are the first successful examples of this approach and several agents that target cytotoxic lympho...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Hottinger AF

    更新日期:2016-12-01 00:00:00

  • Intelligent use of antiepileptic drugs is beneficial to patients.

    abstract:PURPOSE OF REVIEW:To describe the most important issues a clinician must consider whenever selecting and administering antiepileptic drugs (AEDs). There is no available algorithm that identifies how to individualize selection of AEDs. Proper selection and administration can make an enormous difference in both effective...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Cheng JY,French JA

    更新日期:2018-04-01 00:00:00

  • Neuroimaging in developmental disorders.

    abstract:PURPOSE OF REVIEW:This review considers the role of neuroimaging in developmental disorders by highlighting recent studies in two distinct, but overlapping, developmental disorders: autism and fragile X syndrome. RECENT FINDINGS:After a decade of conflicting results in neuroimaging studies of autism, recent studies ha...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Greicius MD

    更新日期:2003-04-01 00:00:00

  • Pathogenic mechanisms in inflammatory and paraproteinaemic peripheral neuropathies.

    abstract:PURPOSE OF REVIEW:This review summarizes the major recent developments in understanding of pathogenic mechanisms in inflammatory and paraproteinaemic neuropathies. RECENT FINDINGS:In the inflammatory neuropathies, there has been a particular focus on antibody-mediated disease affecting the nodal/paranodal regions. Dis...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Rinaldi S,Bennett DL

    更新日期:2014-10-01 00:00:00

  • Controversies in the treatment of Parkinson's disease.

    abstract::Although theoretical reasons exist for believing that selegiline slows the progression of Parkinson's disease, this has not been shown in clinical trials. Selegiline improves the symptoms of Parkinson's disease, allowing the introduction of levodopa to be delayed in de-novo patients and, later, for levodopa to be used...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Hely MA,Morris JG

    更新日期:1996-08-01 00:00:00

  • Interventional treatment of brain ischemia related to intracranial cerebrovascular occlusive lesions.

    abstract:PURPOSE OF REVIEW:This review discusses the present use of interventional transcatheter strategies to treat patients with acute brain ischemia and severe stenosis of intracranial large arteries. RECENT FINDINGS:The benefits and risks of opening freshly occluded intracranial large arteries in patients with brain ischem...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Caplan LR,Thomas AJ,Inoa V

    更新日期:2014-02-01 00:00:00

  • MRI of non-Alzheimer's dementia: current and emerging knowledge.

    abstract:PURPOSE OF REVIEW:The correct classification of non-Alzheimer's dementia is crucial to study disease mechanisms, predict disease progression and test disease-specific treatments. Brain atrophy assessment with morphometric MRI is currently the gold standard for in-vivo localization of neurodegeneration. Structural and f...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Filippi M,Agosta F

    更新日期:2018-08-01 00:00:00

  • Dystonia: an update on phenomenology, classification, pathogenesis and treatment.

    abstract:PURPOSE OF REVIEW:This article will highlight recent advances in dystonia with focus on clinical aspects such as the new classification, syndromic approach, new gene discoveries and genotype-phenotype correlations. Broadening of phenotype of some of the previously described hereditary dystonias and environmental risk f...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Balint B,Bhatia KP

    更新日期:2014-08-01 00:00:00

  • Psychogenic nonepileptic seizures.

    abstract:PURPOSE OF REVIEW:This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizures and developments in treatment. RECENT FINDINGS:The misdiagnosis of nonepileptic seizure is costly to patients, the healthcare system, and to society. Patients with nonepileptic seizures are prescribed ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: LaFrance WC Jr

    更新日期:2008-04-01 00:00:00

  • Management of cervical spondylotic myelopathy with insights from metabolic imaging of the spinal cord and brain.

    abstract:PURPOSE OF REVIEW:Cervical spondylotic myelopathy (CSM) is a potentially debilitating disorder primarily related to spinal cord injury caused by degenerative changes of the spine. As the population continues to age and live longer, it is likely that this disorder will be encountered with increasing frequency. RECENT F...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Holly LT

    更新日期:2009-12-01 00:00:00