Migraine: a brain state.

Abstract:

PURPOSE OF REVIEW:Migraine has traditionally been categorized as a pain disorder, focusing on headache as its central feature. This narrow view does not account for the complex array of premonitory and postrdromal symptoms that occur in the hours before and after headache. This review outlines evidence that supports a broader view of migraine as a pathological brain state. RECENT FINDINGS:Studies of the clinical features of a migraine attack, in combination with imaging and electrophysiological studies, provide evidence that migraine involves widespread changes in brain function and connectivity. These changes parallel those seen in other brain states such as sleep. Neurochemical mediators, including adenosine, and nonsynaptic signalling mechanisms involving astrocytes may play a role in the migraine state. SUMMARY:Consideration of a migraine attack as a brain state provides an expanded framework for understanding all of its symptoms, and the underlying alterations in the activity of multiple brain networks. Mechanisms driving the transition to the migraine state may represent novel targets for acute and preventive therapies.

journal_name

Curr Opin Neurol

authors

Charles A

doi

10.1097/WCO.0b013e32836085f4

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

235-9

issue

3

eissn

1350-7540

issn

1473-6551

journal_volume

26

pub_type

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