Targeting DNA repair in gliomas.

Abstract:

PURPOSE OF REVIEW:Gliomas represent a disparate group of malignancies with varying clinical outcomes despite a tremendous amount of time, effort, and resources dedicated to their management and understanding. The most aggressive entity, glioblastoma, has a dismal prognosis with poor local control despite intense local and systemic treatment, including radiation therapy. RECENT FINDINGS:Given the heterogeneity in genotype, phenotype, and patient outcomes, researchers and clinicians have turned their attention toward attacking DNA damage response and repair mechanisms in gliomas in an effort to develop novel chemo and radiosensitizers. However, despite extensive work in both the laboratory and the clinic, no sensitizers have yet to emerge as clear options in the treatment of glioma, often because of meager preclinical data or an inability to penetrate the blood-brain barrier. SUMMARY:This review will examine current understanding of molecular DNA repair targets in glioma and their potential exploitation to improve local control and, ultimately, overall survival of patients afflicted with these diseases.

journal_name

Curr Opin Neurol

authors

Beckta JM,Bindra RS,Chalmers AJ

doi

10.1097/WCO.0000000000000760

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

878-885

issue

6

eissn

1350-7540

issn

1473-6551

journal_volume

32

pub_type

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