Depression in epilepsy.

Abstract:

PURPOSE OF REVIEW:To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS:Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms preceding the onset of the epilepsy. Suicide is also three times more frequent in epilepsy than in the general population. Reliable screening instruments for depression and suicidality in patients with epilepsy are now available but data from real life clinical settings are needed to develop shared clinical pathways between neurology and psychiatry. Data in children with epilepsy are still limited although it is well known that, outside epilepsy, almost 50% of adult patients with mood and anxiety disorders have a previous history during childhood. Despite increasing attention to the problem, the additional stigma associated with mental health problems still represents one of the major barriers to prompt diagnosis and treatment. SUMMARY:New studies will focus on the development of shared clinical pathways between neurology and psychiatry for mood disorders and suicide prevention. New global campaigns on the double stigma will support this process in areas where psychiatric comorbidities are still underdiagnosed and undertreated.

journal_name

Curr Opin Neurol

authors

Mula M

doi

10.1097/WCO.0000000000000431

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

180-186

issue

2

eissn

1350-7540

issn

1473-6551

journal_volume

30

pub_type

杂志文章,评审
  • Deciphering spreading mechanisms in amyotrophic lateral sclerosis: clinical evidence and potential molecular processes.

    abstract:PURPOSE OF REVIEW:The aim of this review is to refer to recent arguments supporting the existence of specific propagation mechanisms associated with spreading of neuron injury in amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:Misfolded ALS-linked protein accumulation can induce aggregation of their native equiva...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000239

    authors: Pradat PF,Kabashi E,Desnuelle C

    更新日期:2015-10-01 00:00:00

  • Learning and memory: recent findings.

    abstract::Recent findings from neuroimaging, event-related potential and lesion investigations reflect a rapidly emerging view that the memory system is widely distributed throughout the cortex. It is clear that the pattern of cortical involvement during encoding and retrieval of memories is critically dependent on the nature a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200108000-00004

    authors: Bright P,Kopelman MD

    更新日期:2001-08-01 00:00:00

  • New management algorithms in multiple sclerosis.

    abstract:PURPOSE OF REVIEW:Our current treatment algorithms include only IFN-β and glatiramer as available first-line disease-modifying drugs and natalizumab and fingolimod as second-line therapies. Today, 10 drugs have been approved in Europe and nine in the United States making the choice of therapy more complex. The purpose ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000096

    authors: Sorensen PS

    更新日期:2014-06-01 00:00:00

  • Deep brain stimulation in epilepsy: what is next?

    abstract:PURPOSE OF REVIEW:Experimental and clinical studies have suggested that epileptic seizures can be modulated or interrupted by electrical stimulations of subcortical structures that may exert a remote control on seizure generators. The aim of this review is to present these recent reports and to address the perspectives...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3283374a39

    authors: Kahane P,Depaulis A

    更新日期:2010-04-01 00:00:00

  • The influence of anxiety on ocular motor control and gaze.

    abstract:PURPOSE OF REVIEW:The influence of anxiety on ocular motor control and gaze has received less research attention than its effects on postural control and locomotion. This review summarizes research on trait anxiety, state anxiety, anxiety disorders, ocular motor reflexes, and gaze. It applies these findings to clinical...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000055

    authors: Staab JP

    更新日期:2014-02-01 00:00:00

  • Community integration following severe childhood traumatic brain injury.

    abstract:PURPOSE OF REVIEW:Severe childhood traumatic brain injury (TBI) is the leading cause of death and acquired disability in children, causing impairments in children's sensory-motor, cognitive and behavioural functioning, with devastating consequences on community integration. Community integration is the ultimate goal of...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328340296f

    authors: Chevignard MP,Brooks N,Truelle JL

    更新日期:2010-12-01 00:00:00

  • Inflammatory disorders of muscle: progress in polymyositis, dermatomyositis and inclusion body myositis.

    abstract:PURPOSE OF REVIEW:To provide an update on the major advances in inflammatory myopathies. RECENT FINDINGS:Polymyositis is an uncommon disorder that can be misdiagnosed when the old, and never validated, criteria of Bohan and Peter are used. New diagnostic criteria were recently introduced, in which the MHC/CD8 complex ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200410000-00006

    authors: Dalakas MC

    更新日期:2004-10-01 00:00:00

  • Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain.

    abstract::Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis. These include now well-recognized alterations of neuronal biochemical mar...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200206000-00004

    authors: Wolinsky JS,Narayana PA

    更新日期:2002-06-01 00:00:00

  • Examining the ocular fundus in neurology.

    abstract:PURPOSE OF REVIEW:The funduscopic examination can be a technically difficult, and often omitted, portion of the neurologic examination, despite its great potential to influence patient care. RECENT FINDINGS:Medical practitioners are often first taught to examine the ocular fundus using a direct ophthalmoscope, however...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000637

    authors: Rodenbeck SJ,Mackay DD

    更新日期:2019-02-01 00:00:00

  • Imaging in cerebrovascular disease.

    abstract::Various functional imaging modalities can be applied in acute ischaemic stroke to identify functionally impaired, but morphologically preserved tissue (i.e. the penumbra), and to distinguish it from irreversibly damaged tissue. Flow thresholds for irreversible tissue destruction resulting in functional impairment, as ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200102000-00011

    authors: Heiss WD,Forsting M,Diener HC

    更新日期:2001-02-01 00:00:00

  • Epidemiology and outcomes of acute encephalitis.

    abstract:PURPOSE OF REVIEW:This review seeks to describe recent advances in the epidemiology, outcomes, and prognostic factors in acute encephalitis. RECENT FINDINGS:Infectious causes continue to account for the largest proportion of encephalitis cases in which a cause is identified, although autoimmune causes are increasingly...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000199

    authors: Venkatesan A

    更新日期:2015-06-01 00:00:00

  • MRI monitoring of spinal cord changes in patients with multiple sclerosis.

    abstract:PURPOSE OF REVIEW:We analyze recent data on technical aspects, clinical indications, and imaging features of spinal cord MRI in multiple sclerosis, and on the value of this examination for assessing the type and extension of spinal cord damage, and for predicting prognosis in patients with this disease. RECENT FINDING...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000343

    authors: Rovira A,de Stefano N

    更新日期:2016-08-01 00:00:00

  • New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?

    abstract:PURPOSE OF REVIEW:Valproic acid (VPA) is one of the four first line antiepileptic drugs (AEDs). VPA is also an effective drug in migraine prophylaxis and in treatment of bipolar disorders. The use of VPA is limited by its two rare but potentially life-threatening side effects, teratogenicity and hepatotoxicity, and it ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000063774.81810.30

    authors: Isoherranen N,Yagen B,Bialer M

    更新日期:2003-04-01 00:00:00

  • The growing clinical spectrum of cerebral amyloid angiopathy.

    abstract:PURPOSE OF REVIEW:Cerebral amyloid angiopathy (CAA) is diagnosed primarily as a cause of lobar intracerebral hemorrhages (ICH) in elderly patients. With improving MRI techniques, however, the role of CAA in causing other symptoms has become clear. Recognizing the full clinical spectrum of CAA is important for diagnosis...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000510

    authors: Wermer MJH,Greenberg SM

    更新日期:2018-02-01 00:00:00

  • Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?

    abstract:PURPOSE OF REVIEW:This review aims to determine whether it is cost-effective to replace aspirin and warfarin with more effective, yet more costly, treatments for secondary stroke prevention. RECENT FINDINGS:For preventing recurrent stroke of arterial origin, clopidogrel and the combination of aspirin and extended-rele...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328334e67b

    authors: Hankey GJ

    更新日期:2010-02-01 00:00:00

  • Epidemiology and natural history of multiple sclerosis: new insights.

    abstract:PURPOSE OF REVIEW:The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. RECENT FINDINGS:Genetic advances strengthen the association of multiple sclerosis with the human leukocy...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000227033.47458.82

    authors: Kantarci O,Wingerchuk D

    更新日期:2006-06-01 00:00:00

  • Tremor entities and their classification: an update.

    abstract:PURPOSE OF REVIEW:This review focuses on important new findings in the field of tremor and illustrates the consequences for the current definition and classification of tremor. RECENT FINDINGS:Since 1998 when the consensus criteria for tremor were proposed, new variants of tremors and new diagnostic methods were disco...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000211

    authors: Gövert F,Deuschl G

    更新日期:2015-08-01 00:00:00

  • Respiratory failure because of neuromuscular disease.

    abstract:PURPOSE OF REVIEW:Understanding the mechanisms and abnormalities of respiratory function in neuromuscular disease is critical to supporting the patient and maintaining ventilation in the face of acute or chronic progressive impairment. RECENT FINDINGS:Retrospective clinical studies reviewing the care of patients with ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000363

    authors: Howard RS

    更新日期:2016-10-01 00:00:00

  • Recent advances in mechanisms of spreading depression.

    abstract::Although spreading depression has been known for over 50 years, recent research into this interesting experimental phenomenon provides evidence for an integrative role of spreading depression in brain pathophysiology. Spreading depression activates neurophysiological pathways that may have widespread consequences on b...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199806000-00006

    authors: Parsons AA

    更新日期:1998-06-01 00:00:00

  • Update on uveomeningoencephalitides.

    abstract:PURPOSE OF REVIEW:Uveomeningoencephalitides, commonly known as Vogt-Koyanagi-Harada (VKH) disease, are characterized by chronic bilateral granulomatous panuveitis involving the central nervous, auditory and integumentary systems. Visual prognosis is generally favourable, but outcomes in patients with VKH disease may va...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000169753.31321.4e

    authors: Sheu SJ

    更新日期:2005-06-01 00:00:00

  • Fetal tissue transplantation [correction of transplanation] in Parkinson's disease.

    abstract::Since the first successful attempts in 1990, human embryonic tissue transplantation has attracted the attention of multiple investigators and clinicians as a serious candidate therapy for Parkinson's disease. Although over two hundred patients have undergone the procedure, multiple issues and questions remain unresolv...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199808000-00010

    authors: Tabbal S,Fahn S,Frucht S

    更新日期:1998-08-01 00:00:00

  • Magnetic resonance imaging and spectroscopy in multiple sclerosis.

    abstract::Stimulated by the impressive effect of interferon beta on magnetic resonance imaging-detected disease activity, the past year or so has seen a particular interest in the use of magnetic resonance imaging to monitor treatment. To be effective in this regard, there needs to be a high sensitivity and accuracy in detectin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199506000-00009

    authors: Miller DH

    更新日期:1995-06-01 00:00:00

  • Memory and language in neurodegenerative diseases.

    abstract::This article reviews recent studies concerning memory and language disorders in Alzheimer's disease and other neurodegenerative conditions. It shows how different memory and language subcomponents may differentially be impaired in different neurodegenerative diseases and at different stages of the same disease. ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199810000-00003

    authors: Dalla Barba G,Boller F

    更新日期:1998-10-01 00:00:00

  • Chlamydia pneumoniae infection of the central nervous system.

    abstract::Chlamydia pneumoniae is a common respiratory pathogen that is now being implicated in a number of chronic diseases. That the organism can infect vascular endothelium, macrophages and smooth muscle cells suggests that it may play a role in many systemic diseases. The present review focuses on the possibility that the c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200106000-00015

    authors: Yucesan C,Sriram S

    更新日期:2001-06-01 00:00:00

  • Drug-induced myopathies.

    abstract::Two major entities continue to be controversial in the field of clinical myotoxicity: the various myopathies that are induced by the cholesterol-lowering agents and the acute quadriplegic myopathy of intensive care. Both conditions are relatively common, but their pathogenesis is unclear. The problematic issues relate...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200010000-00006

    authors: Argov Z

    更新日期:2000-10-01 00:00:00

  • Spinocerebellar ataxias: an update.

    abstract:PURPOSE OF REVIEW:Here we discuss recent advances regarding the molecular genetic basis of dominantly inherited ataxias. RECENT FINDINGS:Important recent observations include insights into the mechanisms by which expanded polyglutamine causes cerebellar degeneration; new findings regarding how noncoding expansions may...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3281fbd3dd

    authors: Soong BW,Paulson HL

    更新日期:2007-08-01 00:00:00

  • An update on the leukodsytrophies.

    abstract::This review centers on important recent advances in the understanding of the role of glial fibrillary acidic protein in Alexander disease and of proteolipid protein in hypomyelinating disorders such as Pelizaeus-Merzbacher and spastic paraplegia. We also describe seven novel leukodystrophies. These include childhood a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200112000-00018

    authors: Schiffmann R,Boespflüg-Tanguy O

    更新日期:2001-12-01 00:00:00

  • Genetic treatments in muscular dystrophies.

    abstract:PURPOSE OF REVIEW:The search for a cure for Duchenne muscular dystrophy and other muscular dystrophies is progressing rapidly despite significant challenges posed by some genes and the complexity of targeting all skeletal muscles. This review focuses on three areas in which experimental clinical studies are in progress...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3282efc157

    authors: Muntoni F,Wells D

    更新日期:2007-10-01 00:00:00

  • Exotic and emerging viral encephalitides.

    abstract:PURPOSE OF REVIEW:The exotic and emerging viral encephalitides are caused by animal or human viruses and characterised by sudden unexpected outbreaks of neurological disease, usually in tropical and sub-tropical regions, but sometimes spreading to temperate areas. Although a wide range of viruses come within this label...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000073944.19076.56

    authors: Solomon T

    更新日期:2003-06-01 00:00:00

  • Traumatic brain injury: recent advances in plasticity and regeneration.

    abstract:PURPOSE OF REVIEW:There is an urgent need for effective therapies to restore neurologic function and decrease disability following traumatic brain injury (TBI). Here, emerging findings on the mechanisms of post-TBI neural repair and regeneration, as well as therapeutic implications, are selectively reviewed. RECENT FI...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000265

    authors: Werner JK,Stevens RD

    更新日期:2015-12-01 00:00:00