What have we learned from recent twin studies about the etiology of neurodevelopmental disorders?

abstract：PURPOSE OF REVIEW:To provide an update on immunomodulating and immunosuppressive therapies in myasthenia gravis and highlight newly approved, or pending approval, therapies with new biologics. RECENT FINDINGS:Preoperative IVIg is not needed to prevent myasthenic crisis in stable myasthenia gravis patients scheduled fo...

journal_title：Current opinion in neurology

authors： Dalakas MC

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize advances in our understanding of the clinical phenotypes, genetics, and molecular pathophysiology of the periodic paralyses, the nondystrophic myotonias, and other muscle channelopathies. RECENT FINDINGS:The number of pathogenic mutations causing periodic paralysis, nondystrophic myotoni...

journal_title：Current opinion in neurology

authors： Platt D,Griggs R

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the currently known side effects of the approved therapies of multiple sclerosis and to suggest monitoring procedures. RECENT FINDINGS:The progress in the treatment of multiple sclerosis with new very effective therapies is accompanied by a number of side effects. Some of these have alre...

journal_title：Current opinion in neurology

authors： Moiola L,Rommer PS,Zettl UK

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...

journal_title：Current opinion in neurology

authors： Biagini G,Panuccio G,Avoli M

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Is multiple sclerosis (MS) a generalized disease of the central nervous system? Or put another way, is MS pathology primarily focal with global consequences or global with focal consequences? Consideration of this question depends on how you view it both spatially and temporally. In this review, we ad...

journal_title：Current opinion in neurology

authors： Chard D,Miller D

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe new features on the epidemiology of encephalitis world-wide. As this neurological presentation is most frequently related to transmitted viruses, surveillance of encephalitis is of major importance to detect their emergence or re-emergence. RECENT FINDINGS:Rabies causes o...

journal_title：Current opinion in neurology

authors： Stahl JP,Mailles A

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an urgent need for effective therapies to restore neurologic function and decrease disability following traumatic brain injury (TBI). Here, emerging findings on the mechanisms of post-TBI neural repair and regeneration, as well as therapeutic implications, are selectively reviewed. RECENT FI...

journal_title：Current opinion in neurology

authors： Werner JK,Stevens RD

更新日期：2015-12-01 00:00:00

abstract：:Two major entities continue to be controversial in the field of clinical myotoxicity: the various myopathies that are induced by the cholesterol-lowering agents and the acute quadriplegic myopathy of intensive care. Both conditions are relatively common, but their pathogenesis is unclear. The problematic issues relate...

journal_title：Current opinion in neurology

authors： Argov Z

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The results of phase 2 randomized controlled trials for the prevention of episodic and chronic migraine demonstrating the efficacy and safety of four mAbs targeting the calcitonin gene-related peptide (CGRP) pathway [ALD403 (eptinezumab), AMG334 (erenumab), LY2951742 (galcanezumab) and TEV48125 (frema...

journal_title：Current opinion in neurology

authors： Mitsikostas DD,Reuter U

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Campylobacter jejuni is the most frequent agent of antecedent infection in an axonal variant of Guillain-Barré syndrome, acute motor axonal neuropathy, and anti-GM1 or anti-GD1a IgG antibody is also associated with acute motor axonal neuropathy. Molecular mimicry has been found between human GM1 gangl...

journal_title：Current opinion in neurology

authors： Yuki N,Odaka M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent years have witnessed the discoveries of several genes causing neurodegeneration with brain iron accumulation (NBIA) and subsequently their novel classification scheme was suggested. The first results of treatments with modern chelating drugs are also being published. RECENT FINDINGS:Most recen...

journal_title：Current opinion in neurology

authors： Dusek P,Schneider SA

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The computational power of the brain arises from the complex interactions between neurons. One straightforward method to quantify the strength of neuronal interactions is by measuring correlation and coherence. Efforts to measure correlation have been advancing rapidly of late, spurred by the developm...

journal_title：Current opinion in neurology

authors： Snyder AC,Smith MA

更新日期：2018-02-01 00:00:00

abstract：:Dermatomyositis and polymyositis are treatable disorders of skeletal muscle. Despite their clinical similarities, they appear to have fundamentally different autoimmune origins. Inclusion body myositis, from its origins 30 years ago, has emerged as the commonest acquired myopathy of the elderly. Despite inflammatory c...

journal_title：Current opinion in neurology

authors： Hilton-Jones D

更新日期：2001-10-01 00:00:00

abstract：:Nuclear magnetic resonance methods as a whole have contributed as much to the study and treatment of epilepsy as to any branch of medicine. The pace of the progress in this field increases as recently developed nuclear magnetic resonance techniques mature into practical tools for epilepsy research and management. Rece...

journal_title：Current opinion in neurology

authors： Prichard JW

更新日期：1997-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic discovery has been extremely rapid over the last year, with many new discoveries illuminating novel mechanisms and pathways. In particular, the application of whole exome and whole genome sequencing has identified many new genetic causes of the epilepsies. As such methods become increasingly a...

journal_title：Current opinion in neurology

authors： Sisodiya SM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH). RECENT FINDINGS:The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified a...

journal_title：Current opinion in neurology

authors： Mollan SP,Hoffmann J,Sinclair AJ

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Herein we discuss the recent literature concerning cervicogenic vertigo including vertigo associated with rotational vertebral artery syndrome, as well as whiplash and degenerative disturbances of the cervical spine. We conclude with a summary of progress regarding diagnostic methods for cervicogenic ...

journal_title：Current opinion in neurology

authors： Hain TC

更新日期：2015-02-01 00:00:00

abstract：:This article reviews recent studies evaluating the clinicopathologic markers of progressive supranuclear palsy, which have helped establish standardized clinical and pathologic diagnostic criteria. Although these criteria increase diagnostic accuracy, the clinical and pathologic overlap between progressive supranuclea...

journal_title：Current opinion in neurology

authors： Litvan I

更新日期：1997-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the clinical findings, differential diagnosis, treatment and outcome of pseudotumoral demyelinating lesions including tumefactive demyelination and Baló's concentric sclerosis. RECENT FINDINGS:MRI findings, such as dynamic restricted diffusion changes at the edge of pseudotumoral lesions he...

journal_title：Current opinion in neurology

authors： Hardy TA

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. RECENT FINDINGS:Genetic advances strengthen the association of multiple sclerosis with the human leukocy...

journal_title：Current opinion in neurology

authors： Kantarci O,Wingerchuk D

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Stroke thrombolysis is in the process of moving from academic centers into community-based standard therapy in experienced centers. Recently published data on patient selection, imaging and other technical or organizational advances are reviewed in order to improve the safety and efficacy of stroke th...

journal_title：Current opinion in neurology

authors： Lindsberg PJ,Kaste M

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to assess the seizure manifestations and risk of epilepsy in encephalitis associated with antibodies against neuronal cell-surface (autoimmune encephalitis) or myelin-associated antigens, and to review several chronic epileptic disorders, including Rasmussen's encephalitis, f...

journal_title：Current opinion in neurology

authors： Spatola M,Dalmau J

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Prospective and retrospective incidence cohort studies have been consistent in identifying an increased mortality in patients with epilepsy, although risk ratios vary considerably. Standardized mortality ratios in these populations range from 1.6 to 5.3, but they tend to be higher in studies in select...

journal_title：Current opinion in neurology

authors： Jallon P

更新日期：2004-04-01 00:00:00

abstract：:Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-ophthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biops...

journal_title：Current opinion in neurology

authors： Hooda BS,Finlay JL

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The diagnosis of dementia rests on an improved knowledge and a better detection of early impairments, to which functional imaging can certainly contribute. RECENT FINDINGS:Progress has been observed at different levels. First, the understanding of different dementias has benefited from explorations o...

journal_title：Current opinion in neurology

authors： Salmon E

更新日期：2002-08-01 00:00:00

abstract：:At the dawning of the present decade, deemed appropriately the Decade of the Spine, acute spinal cord injury lingers as a formidable disorder affecting society. The enormous physical, emotional and socioeconomic impact of acute spinal cord injury on society is well known. Consequently, intensive clinical and laborator...

journal_title：Current opinion in neurology

authors： Dumont AS,Dumont RJ,Oskouian RJ

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will summarize new neuroimaging techniques, particularly MRI and PET imaging, that can be used to assess brain tumor growth and angiogenesis. RECENT FINDINGS:Glioma tumor vasculature is abnormal, and advances in MRI now permit visualization of the hemodynamic properties of gliomas includi...

journal_title：Current opinion in neurology

authors： Gerstner ER,Sorensen AG,Jain RK,Batchelor TT

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Trigeminal autonomic cephalgias (TACs) are characterized by frequent, short-lasting headache attacks with ipsilateral facial autonomic features. They include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. The...

journal_title：Current opinion in neurology

authors： Wilbrink LA,Ferrari MD,Kruit MC,Haan J

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of recent developments in diagnosis, pathophysiology, neuroimaging and management of functional (psychogenic) movement disorders (FMD). RECENT FINDINGS:There has been increasing interest to study the underlying pathophysiology of FMD, which has resulted in a broadened...

journal_title：Current opinion in neurology

authors： Czarnecki K,Hallett M

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review seeks to describe recent advances in the epidemiology, outcomes, and prognostic factors in acute encephalitis. RECENT FINDINGS:Infectious causes continue to account for the largest proportion of encephalitis cases in which a cause is identified, although autoimmune causes are increasingly...

journal_title：Current opinion in neurology

authors： Venkatesan A

更新日期：2015-06-01 00:00:00