Epidemiology and natural history of multiple sclerosis: new insights.

abstract：:A review of the literature on methods of seizure or epilepsy severity assessments resulted in tabulation of the seizure rating scales known as US Department of Veterans Affairs (VA), Chalfont-National Hospital, Liverpool, Hague, and others. Each of the scales reviewed has some advantages, but none of them appears to b...

journal_title：Current opinion in neurology

authors： Cramer JA

更新日期：2001-04-01 00:00:00

abstract：:Since the first successful attempts in 1990, human embryonic tissue transplantation has attracted the attention of multiple investigators and clinicians as a serious candidate therapy for Parkinson's disease. Although over two hundred patients have undergone the procedure, multiple issues and questions remain unresolv...

journal_title：Current opinion in neurology

authors： Tabbal S,Fahn S,Frucht S

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Central nervous system infections are not uncommon in systemic vasculitides. Being vigilant of central nervous system infections as an alternative consideration, instead of systemic vasculitides per se, could prove to be lifesaving in certain circumstances. RECENT FINDINGS:Common pathogens, such as t...

journal_title：Current opinion in neurology

authors： Ye S,Yang CD

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent advances in survival for patients with newly diagnosed and recurrent brain tumors, combined with the development of an ever-increasing number of potential treatments, has led to significant growth in the number of clinical trials for patients with brain tumors. Suitable clinical trial design an...

journal_title：Current opinion in neurology

authors： Butowski N,Chang SM

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:We analyze recent data on technical aspects, clinical indications, and imaging features of spinal cord MRI in multiple sclerosis, and on the value of this examination for assessing the type and extension of spinal cord damage, and for predicting prognosis in patients with this disease. RECENT FINDING...

journal_title：Current opinion in neurology

authors： Rovira A,de Stefano N

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

journal_title：Current opinion in neurology

authors： Gallo V,Armstrong RC

更新日期：2008-06-01 00:00:00

abstract：:In multifocal motor or sensorimotor neuropathy with persistent conduction block, most of the recent research has concerned treatment. Open trials show that intravenous immunoglobulin is effective, providing a rapid and often marked clinical improvement, accompanied by a significant reduction of conduction block in som...

journal_title：Current opinion in neurology

authors： Léger JM

更新日期：1995-10-01 00:00:00

abstract：:Magnetic resonance spectroscopy allows neurochemistry to be probed noninvasively in vivo. Recent advances in our understanding of the biochemical significance of the various neurochemicals that are observable allow a variety of pathologic states of relevance to encephalopathies and neurodegenerative disorders to be ob...

journal_title：Current opinion in neurology

authors： Jenkins BG,Kraft E

更新日期：1999-12-01 00:00:00

abstract：:Deletion of the 1.5 Mb tract on chromosome 17p11.2-12 that is duplicated in Charcot-Marie-Tooth disease type 1A is commonly associated with hereditary neuropathy with liability to pressure palsies. The deletion, which originates from an unequal meiotic crossover involving two homologous repeats, causes underexpression...

journal_title：Current opinion in neurology

authors： Pareyson D,Taroni F

更新日期：1996-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Ten years of intensive research are now beginning to bring candidate neuroprotective therapies to clinical trials. This review describes recent progress in basic, preclinical, and clinical research that underlies current and potential neuroprotective trials. RECENT FINDINGS:Basic research continues t...

journal_title：Current opinion in neurology

authors： Hersch SM

更新日期：2003-08-01 00:00:00

abstract：:Neuropharmacology is aiding our understanding of the control of eye movements in at least three ways. First, neurotransmitters have been identified in the pathways that coordinate gaze. Second, the technique of pharmacologic inactivation has provided a powerful method to determine the contributions of populations of n...

journal_title：Current opinion in neurology

authors： Leigh RJ,Ramat S

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent terminations of clinical trials of myostatin inhibitors in muscular dystrophy have raised questions about the predictiveness of mouse models for this therapeutic strategy. RECENT FINDINGS:A variety of myostatin inhibitors have been developed for preclinical and clinical studies. These inhibito...

journal_title：Current opinion in neurology

authors： Wagner KR

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS:Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or di...

journal_title：Current opinion in neurology

authors： Draganski B,Lutti A,Kherif F

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Stroke is the third leading cause of death after myocardial infarction and cancer, and is the leading cause of permanent disability and disability-adjusted loss of independent life-years in western countries. Thrombolysis is the treatment of choice for acute stroke within 3 h after the onset of sympto...

journal_title：Current opinion in neurology

authors： Schellinger PD,Kaste M,Hacke W

更新日期：2004-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on important new findings in the field of tremor and illustrates the consequences for the current definition and classification of tremor. RECENT FINDINGS:Since 1998 when the consensus criteria for tremor were proposed, new variants of tremors and new diagnostic methods were disco...

journal_title：Current opinion in neurology

authors： Gövert F,Deuschl G

更新日期：2015-08-01 00:00:00

abstract：:Dermatomyositis and polymyositis are treatable disorders of skeletal muscle. Despite their clinical similarities, they appear to have fundamentally different autoimmune origins. Inclusion body myositis, from its origins 30 years ago, has emerged as the commonest acquired myopathy of the elderly. Despite inflammatory c...

journal_title：Current opinion in neurology

authors： Hilton-Jones D

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This article will review the recent experience with West Nile virus encephalitis and myelitis. RECENT FINDINGS:In the summer of 2003, the majority of cases of West Nile virus infection in the United States were reported from the western states. The transmission of West Nile virus through blood transf...

journal_title：Current opinion in neurology

authors： Roos KL

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic and often disabling neuropathy, which often responds to immune therapies including corticosteroids, plasma exchange, and high-dose intravenous immunoglobulin (IVIg). The reasons for choosing one of these therapies and the fa...

journal_title：Current opinion in neurology

authors： Nobile-Orazio E,Gallia F

更新日期：2015-10-01 00:00:00

abstract：:Chlamydia pneumoniae is a common respiratory pathogen that is now being implicated in a number of chronic diseases. That the organism can infect vascular endothelium, macrophages and smooth muscle cells suggests that it may play a role in many systemic diseases. The present review focuses on the possibility that the c...

journal_title：Current opinion in neurology

authors： Yucesan C,Sriram S

更新日期：2001-06-01 00:00:00

abstract：:Migraine is an episodic headache disorder that occurs with or without aura and is often accompanied by other symptoms. Treatment must address these associated symptoms as well as the headache, and it can involve either acute or preventive therapy alone or a combination of both. Acute therapy treats the individual atta...

journal_title：Current opinion in neurology

authors： Silberstein SD

更新日期：1994-06-01 00:00:00

abstract：:This paper reviews current knowledge about epileptogenesis in the developing brain. Animal studies indicate that the maturational balance of excitatory and inhibitory neurotransmitter systems should result in an increased susceptibility to seizures. However, the reason for specific age-locked syndromes and the high ra...

journal_title：Current opinion in neurology

authors： Scott RC,Neville BG

更新日期：1998-04-01 00:00:00

abstract：:Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-ophthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biops...

journal_title：Current opinion in neurology

authors： Hooda BS,Finlay JL

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Tuberous sclerosis complex (TSC) is a multiorgan genetic disease caused by mutations in the TSC1 or TSC2 genes. TSC has been recognized for many years as an important cause of severe neurological disease with patients suffering from epilepsy, developmental delay, autism, and psychiatric problems. Duri...

journal_title：Current opinion in neurology

authors： Ess KC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss aspects of cytokine networks in neuroinflammatory diseases and attempt to provide some explanation for our failures and successes in translating preclinical data to benefit patients with multiple sclerosis (MS). We will discuss innate cytokines such as tumor necrosis factor al...

journal_title：Current opinion in neurology

authors： Codarri L,Fontana A,Becher B

更新日期：2010-06-01 00:00:00

abstract：:There is a spectrum of acute autonomic neuropathies. Acute panautonomic neuropathy (pandysautonomia), characterized by severe widespread sympathetic and parasympathetic failure, is at one extreme. Guillain-Barré syndrome is at the other end of the spectrum, where the brunt of the disorder falls on the somatic nervous ...

journal_title：Current opinion in neurology

authors： Low PA

更新日期：1994-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Human ischemic stroke is a multistage disorder with different options for recovery. Imaging has opened a window to explore the pathophysiology and recovery mechanisms of ischemic stroke in vivo. RECENT FINDINGS:It was shown that in the acute phase, arterial recanalization and reperfusion are the most...

journal_title：Current opinion in neurology

authors： Seitz RJ

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. RECENT FINDINGS:Recent twin studies have confirmed that NDDs show moderate-to-hi...

journal_title：Current opinion in neurology

authors： Posthuma D,Polderman TJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The demyelinating disease multiple sclerosis has an autoimmune inflammatory component, which has dominated the description of multiple sclerosis. A degenerative component to multiple sclerosis was always apparent, but was underappreciated until recently. Recent work has brought axonal pathology and br...

journal_title：Current opinion in neurology

authors： Owens T

更新日期：2003-06-01 00:00:00

abstract：:The review intends to draw the attention of researchers working in retinal degenerations on the fact that classical apoptosis, for example, apoptosis triggering caspase activation, may not be the main pathway of cellular demise in this tissue.Former work already showed the difficulty of proving the activation of apopt...

journal_title：Current opinion in neurology

authors： Torriglia A,Jaadane I,Lebon C

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Is multiple sclerosis (MS) a generalized disease of the central nervous system? Or put another way, is MS pathology primarily focal with global consequences or global with focal consequences? Consideration of this question depends on how you view it both spatially and temporally. In this review, we ad...

journal_title：Current opinion in neurology

authors： Chard D,Miller D

更新日期：2009-06-01 00:00:00