Impact of brain aging and neurodegeneration on cognition: evidence from MRI.

abstract：:Neuropharmacology is aiding our understanding of the control of eye movements in at least three ways. First, neurotransmitters have been identified in the pathways that coordinate gaze. Second, the technique of pharmacologic inactivation has provided a powerful method to determine the contributions of populations of n...

journal_title：Current opinion in neurology

authors： Leigh RJ,Ramat S

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses current data on nosological boundaries related to diagnosis, pathophysiology and therapeutic strategies in chronic tension-type headache (CTTH). RECENT FINDINGS:Diagnostic criteria of CTTH should be adapted to improve its sensitivity against migraine. It seems that mechanical pa...

journal_title：Current opinion in neurology

authors： Fernández-de-las-Peñas C,Schoenen J

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Valproic acid (VPA) is one of the four first line antiepileptic drugs (AEDs). VPA is also an effective drug in migraine prophylaxis and in treatment of bipolar disorders. The use of VPA is limited by its two rare but potentially life-threatening side effects, teratogenicity and hepatotoxicity, and it ...

journal_title：Current opinion in neurology

authors： Isoherranen N,Yagen B,Bialer M

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS:Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms precedin...

journal_title：Current opinion in neurology

authors： Mula M

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The risk of suicide is thought be increased in epilepsy. Antiepileptic drugs (AEDs) remain the primary treatment. An FDA alert in 2008 raised concerns that AEDs may increase the risk of suicidal thoughts and behaviour. The risk profile for suicide in epilepsy is examined in the context of recent repor...

journal_title：Current opinion in neurology

authors： Bagary M

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of epilepsy and seizure disorders caused by autoantibodies to specific neuronal membrane proteins has developed significantly during the past few years. RECENT FINDINGS:Antibodies to cell-surface membrane proteins such as voltage-gated potassium channels or N-methyl-D-aspartate receptors,...

journal_title：Current opinion in neurology

authors： Vincent A,Irani SR,Lang B

更新日期：2010-04-01 00:00:00

abstract：:This is a review of chemotherapy options for patients with brain tumors, both at the time of initial diagnosis and at recurrence. Gliomas, the most common malignant brain tumors, represent the main focus of the review; chemotherapeutic options for supratentorial, brain stem, and optic track gliomas are discussed. ...

journal_title：Current opinion in neurology

authors： Galanis E,Buckner JC

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the background, principles and implementation of the Stroke Action Plan for Europe 2018--2030 (SAP-E) in the perspective of the current COVID-19 pandemic. RECENT FINDINGS:SAP-E sets targets for the implementation of evidence-based preventive actions and stroke services to 2030. A recent m...

journal_title：Current opinion in neurology

authors： Christensen H,Pezzella FR,Action Plan for Stroke in Europe Implementation Steering Committee.

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on immunomodulating and immunosuppressive therapies in myasthenia gravis and highlight newly approved, or pending approval, therapies with new biologics. RECENT FINDINGS:Preoperative IVIg is not needed to prevent myasthenic crisis in stable myasthenia gravis patients scheduled fo...

journal_title：Current opinion in neurology

authors： Dalakas MC

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intens...

journal_title：Current opinion in neurology

authors： Cimbalnik J,Kucewicz MT,Worrell G

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review on traumatic brain injury consolidates the substantial current literature available on the pathophysiology, mechanisms, developments, and their subsequent effects on outcome. In particular, it tries to conceptualize why our greatly improved understanding of pathophysiology and neurobiology...

journal_title：Current opinion in neurology

authors： Nortje J,Menon DK

更新日期：2004-12-01 00:00:00

abstract：:A review of the literature on methods of seizure or epilepsy severity assessments resulted in tabulation of the seizure rating scales known as US Department of Veterans Affairs (VA), Chalfont-National Hospital, Liverpool, Hague, and others. Each of the scales reviewed has some advantages, but none of them appears to b...

journal_title：Current opinion in neurology

authors： Cramer JA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...

journal_title：Current opinion in neurology

authors： Biagini G,Panuccio G,Avoli M

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH). RECENT FINDINGS:The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified a...

journal_title：Current opinion in neurology

authors： Mollan SP,Hoffmann J,Sinclair AJ

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent progress in serological screening for paraneoplastic autoantibodies and diagnostic imaging techniques to detect malignancies has resulted in a broadening of the concept of paraneoplastic neurologic syndromes through the characterization of nonclassical clinical features. The goal of this articl...

journal_title：Current opinion in neurology

authors： Koike H,Tanaka F,Sobue G

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on our knowledge regarding prevention and management of medication overuse headache (MOH). RECENT FINDINGS:The prevalence of MOH is 1-2% in the general population worldwide, and because of the tremendous socio-economic cost, it is likely to be the most costly neurologic...

journal_title：Current opinion in neurology

authors： Russell MB,Lundqvist C

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

journal_title：Current opinion in neurology

authors： Gallo V,Armstrong RC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to review recent publications on amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:The Awaji recommendations for electrophysiological diagnosis will permit earlier clinical trials entry. The use of ultrasound to visualize fasciculations, even in deep muscles, will contribute to earlier ...

journal_title：Current opinion in neurology

authors： de Carvalho M,Swash M

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Status epilepticus refractory to first and second-line anticonvulsants represents an outstanding challenge to the medical team. This review covers new insights into the anaesthetic and intensive care of status epilepticus. RECENT FINDINGS:In the anaesthetic treatment of status epilepticus, barbiturat...

journal_title：Current opinion in neurology

authors： Holtkamp M

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Longitudinal studies that use MRI scans performed over multiple time-points have been increasingly employed in the study of different neurological disorders, including degenerative dementia, multiple sclerosis, and epilepsy. RECENT FINDINGS:Although it is well established that increased rates of brai...

journal_title：Current opinion in neurology

authors： Whitwell JL

更新日期：2008-08-01 00:00:00

abstract：:An increasing number of mutations in the CACNA1A gene have been identified, which are associated with a broad clinical spectrum, including familial hemiplegic migraine. Transfection studies and mouse model analyses are currently being undertaken to study the correlation between CACNA1A mutations and disease. ...

journal_title：Current opinion in neurology

authors： Kors EE,van den Maagdenberg AM,Plomp JJ,Frants RR,Ferrari MD

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the most important issues a clinician must consider whenever selecting and administering antiepileptic drugs (AEDs). There is no available algorithm that identifies how to individualize selection of AEDs. Proper selection and administration can make an enormous difference in both effective...

journal_title：Current opinion in neurology

authors： Cheng JY,French JA

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic discovery has been extremely rapid over the last year, with many new discoveries illuminating novel mechanisms and pathways. In particular, the application of whole exome and whole genome sequencing has identified many new genetic causes of the epilepsies. As such methods become increasingly a...

journal_title：Current opinion in neurology

authors： Sisodiya SM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Experimental and clinical studies have suggested that epileptic seizures can be modulated or interrupted by electrical stimulations of subcortical structures that may exert a remote control on seizure generators. The aim of this review is to present these recent reports and to address the perspectives...

journal_title：Current opinion in neurology

authors： Kahane P,Depaulis A

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article will highlight recent advances in dystonia with focus on clinical aspects such as the new classification, syndromic approach, new gene discoveries and genotype-phenotype correlations. Broadening of phenotype of some of the previously described hereditary dystonias and environmental risk f...

journal_title：Current opinion in neurology

authors： Balint B,Bhatia KP

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Precise localization of the epileptogenic zone is imperative for the success of resective surgery of drug-resistant epileptic patients. To decrease the number of surgical failures, clinical research has been focusing on finding new biomarkers. For the past decades, high-frequency oscillations (HFOs, 8...

journal_title：Current opinion in neurology

authors： Roehri N,Bartolomei F

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of chemotherapy in low-grade glioma has been redefined with the long-term follow-up of the RTOG 9802, which investigated adjuvant procarbazine, CCNU, and vincristine (PCV) chemotherapy in addition to radiotherapy, and the results of EORTC trial 22033 in a similar patient population that compa...

journal_title：Current opinion in neurology

authors： van den Bent MJ

更新日期：2015-12-01 00:00:00

abstract：:Ablative surgery and deep brain stimulation for Parkinson's disease can be performed in the thalamus, the pallidum and the subthalamic nucleus. The efficacy and safety of unilateral pallidotomy is well established. Deep brain stimulation has a lower morbidity and is preferred for bilateral surgery. The subthalamic nuc...

journal_title：Current opinion in neurology

authors： Krack P,Hamel W,Mehdorn HM,Deuschl G

更新日期：1999-08-01 00:00:00

abstract：:In multifocal motor or sensorimotor neuropathy with persistent conduction block, most of the recent research has concerned treatment. Open trials show that intravenous immunoglobulin is effective, providing a rapid and often marked clinical improvement, accompanied by a significant reduction of conduction block in som...

journal_title：Current opinion in neurology

authors： Léger JM

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of recent developments in diagnosis, pathophysiology, neuroimaging and management of functional (psychogenic) movement disorders (FMD). RECENT FINDINGS:There has been increasing interest to study the underlying pathophysiology of FMD, which has resulted in a broadened...

journal_title：Current opinion in neurology

authors： Czarnecki K,Hallett M

更新日期：2012-08-01 00:00:00