Amyotrophic lateral sclerosis: an update.

abstract：PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

journal_title：Current opinion in neurology

authors： Ai S,Klein RS

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

journal_title：Current opinion in neurology

authors： Schofield TM,Leff AP

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize why there are polarized opinions regarding the management of patients with asymptomatic carotid disease and whether it is possible to identify patients who might benefit from carotid interventions. RECENT FINDINGS:Carotid Revascularization Endarterectomy Versus Stenting Trial and Asympto...

journal_title：Current opinion in neurology

authors： Naylor AR

更新日期：2017-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 25 years, many autoantibodies directed against peripheral nerve glycan and protein antigens have been described. Principally through this area of research, significant advances have been achieved in the understanding of the pathophysiology of inflammatory neuropathies. More evidence cons...

journal_title：Current opinion in neurology

authors： Chavada G,Willison HJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

journal_title：Current opinion in neurology

authors： Bromley RL,Baker GA,Meador KJ

更新日期：2009-04-01 00:00:00

abstract：:Since the first successful attempts in 1990, human embryonic tissue transplantation has attracted the attention of multiple investigators and clinicians as a serious candidate therapy for Parkinson's disease. Although over two hundred patients have undergone the procedure, multiple issues and questions remain unresolv...

journal_title：Current opinion in neurology

authors： Tabbal S,Fahn S,Frucht S

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Convergent evidence from a number of neuroscience disciplines supports the hypothesis that Alzheimer's disease and other neurodegenerative disorders progress along brain networks. This review considers the role of neuroimaging in strengthening the case for network-based neurodegeneration and elucidati...

journal_title：Current opinion in neurology

authors： Greicius MD,Kimmel DL

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent work using advanced imaging approaches that have improved our understanding of the underlying neural mechanisms associated with disrupted brain development or demonstrated the potential of MRI to provide objective biomarkers of cerebral injury that relate to subsequent ne...

journal_title：Current opinion in neurology

authors： Counsell SJ,Ball G,Edwards AD

更新日期：2014-04-01 00:00:00

abstract：:Various functional imaging modalities can be applied in acute ischaemic stroke to identify functionally impaired, but morphologically preserved tissue (i.e. the penumbra), and to distinguish it from irreversibly damaged tissue. Flow thresholds for irreversible tissue destruction resulting in functional impairment, as ...

journal_title：Current opinion in neurology

authors： Heiss WD,Forsting M,Diener HC

更新日期：2001-02-01 00:00:00

abstract：:Autoimmune ataxic neuropathies are a subset of the sensory ataxic neuropathies which are characterized by ataxia as the dominant presenting feature. The major known causes of autoimmune ataxic neuropathies include sensory variants of the Guillain-Barré syndrome, including Miller-Fisher syndrome, subsets of immunoglobu...

journal_title：Current opinion in neurology

authors： O'Leary CP,Willison HJ

更新日期：1997-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments. RECENT FINDINGS:Several recent review documents have summarized the current position regarding neuroreha...

journal_title：Current opinion in neurology

authors： Thompson AJ

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of chemotherapy in low-grade glioma has been redefined with the long-term follow-up of the RTOG 9802, which investigated adjuvant procarbazine, CCNU, and vincristine (PCV) chemotherapy in addition to radiotherapy, and the results of EORTC trial 22033 in a similar patient population that compa...

journal_title：Current opinion in neurology

authors： van den Bent MJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Ten years of intensive research are now beginning to bring candidate neuroprotective therapies to clinical trials. This review describes recent progress in basic, preclinical, and clinical research that underlies current and potential neuroprotective trials. RECENT FINDINGS:Basic research continues t...

journal_title：Current opinion in neurology

authors： Hersch SM

更新日期：2003-08-01 00:00:00

abstract：:Disability following head injury varies depending on injury mechanism, neuropathology, and other factors, including medical complications. Mild head injury (Glasgow Coma Scale score 13-15) has been shown to have considerable variability in outcome. Some persons experience rapid symptom resolution whereas others contin...

journal_title：Current opinion in neurology

authors： Macciocchi SN,Reid DB,Barth JT

更新日期：1993-10-01 00:00:00

abstract：:Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...

journal_title：Current opinion in neurology

authors： Biering-Sørensen F,Hartkopp A

更新日期：1995-12-01 00:00:00

abstract：:The population of pediatric patients with cerebrovascular disease presents a unique set of challenges to the neurosurgeon. The wide scope of pathology, including arteriovenous malformations, cavernous malformations and moyamoya disease, coupled with marked advances in diagnosis and treatment of these conditions over t...

journal_title：Current opinion in neurology

authors： Smith ER,Butler WE,Ogilvy CS

更新日期：2002-04-01 00:00:00

abstract：:Neural circuits comprised of dopamine-containing and dopamine-receptive neurons are altered functionally after the repeated intermittent administration of cocaine and its withdrawal. The characterization of these neuroadaptive changes at various times after repeated exposure to cocaine is important because they may re...

journal_title：Current opinion in neurology

authors： Pilotte NS

更新日期：1997-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The advent of novel techniques for tracing connections in vivo, such as diffusion tensor magnetic resonance imaging tractography, allows us, for the first time in the human brain, to study the microstructural integrity of white matter fibres and perform virtual dissections of large scale neurocognitiv...

journal_title：Current opinion in neurology

authors： Catani M

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:With the aging of the population, treatment of painful neuropathies is becoming more and more important for neurological practice. This short review highlights recent findings and current problems. RECENT FINDINGS:In addition to tricyclic antidepressants and gabapentin, the reliability of which is es...

journal_title：Current opinion in neurology

authors： Cruccu G

更新日期：2007-10-01 00:00:00

abstract：:Insight into the pathomechanisms of the benign positional vertigo syndromes has led to quick and effective treatment with positional manoeuvres. Our understanding of other causes of vertigo is progressing at a slower pace, but several recent findings regarding vestibular neuritis, vascular compression of the eighth ne...

journal_title：Current opinion in neurology

authors： Lempert T

更新日期：1998-02-01 00:00:00

abstract：:Subacute focal encephalitis of Rasmussen involves cortical inflammatory infiltration which may on occasion be bilateral. The presence of anti-Glu R3 antibodies in some patients suggests that an autoimmune process may be involved. Although a small number of patients respond transiently to immunoglobulins and the condit...

journal_title：Current opinion in neurology

authors： Dulac O

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The trigeminal autonomic reflex is a physiological reflex with an important protective function which also plays a role in pathophysiological conditions, such as primary headache. It is not understood whether the autonomic symptoms in trigeminal autonomic cephalalgias and migraine are the consequence ...

journal_title：Current opinion in neurology

authors： Möller M,May A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to specify the genetic causes of dominantly and recessively inherited axonal forms of Charcot-Marie-Tooth disease (CMT) and review the biological basis for these disorders. RECENT FINDINGS:More than 10 genes that cause axonal CMT have been identified over the past decade. Many of these gen...

journal_title：Current opinion in neurology

authors： Shy ME,Patzkó A

更新日期：2011-10-01 00:00:00

abstract：:Although theoretical reasons exist for believing that selegiline slows the progression of Parkinson's disease, this has not been shown in clinical trials. Selegiline improves the symptoms of Parkinson's disease, allowing the introduction of levodopa to be delayed in de-novo patients and, later, for levodopa to be used...

journal_title：Current opinion in neurology

authors： Hely MA,Morris JG

更新日期：1996-08-01 00:00:00

abstract：:Although spreading depression has been known for over 50 years, recent research into this interesting experimental phenomenon provides evidence for an integrative role of spreading depression in brain pathophysiology. Spreading depression activates neurophysiological pathways that may have widespread consequences on b...

journal_title：Current opinion in neurology

authors： Parsons AA

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:For a long time, cognitive impairment in multiple sclerosis patients has been considered less important than, for instance, physical disability. This is no longer true because of the crucial role that cognitive deficits play in the good day-to-day adjustment of patients. This review highlights recent ...

journal_title：Current opinion in neurology

authors： Hoffmann S,Tittgemeyer M,von Cramon DY

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The successful motor rehabilitation of stroke, traumatic brain-injured and spinal cord-injured patients requires an intensive and task-specific therapy approach. Budget constraints limit a hand-to-hand therapy approach, so that intelligent machines may offer a solution to promote motor recovery and ob...

journal_title：Current opinion in neurology

authors： Hesse S,Schmidt H,Werner C,Bardeleben A

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to refer to recent arguments supporting the existence of specific propagation mechanisms associated with spreading of neuron injury in amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:Misfolded ALS-linked protein accumulation can induce aggregation of their native equiva...

journal_title：Current opinion in neurology

authors： Pradat PF,Kabashi E,Desnuelle C

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:New insights into the psychophysiological determinants of performance changes and brain plasticity associated with motor sequence learning have recently been gained through behavioral and imaging studies in healthy individuals. In addition, using a variety of motor sequential paradigms in groups of pa...

journal_title：Current opinion in neurology

authors： Doyon J

更新日期：2008-08-01 00:00:00

abstract：:Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-ophthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biops...

journal_title：Current opinion in neurology

authors： Hooda BS,Finlay JL

更新日期：1999-12-01 00:00:00