Calcium channel mutations and migraine.

Abstract:

:An increasing number of mutations in the CACNA1A gene have been identified, which are associated with a broad clinical spectrum, including familial hemiplegic migraine. Transfection studies and mouse model analyses are currently being undertaken to study the correlation between CACNA1A mutations and disease.

journal_name

Curr Opin Neurol

authors

Kors EE,van den Maagdenberg AM,Plomp JJ,Frants RR,Ferrari MD

doi

10.1097/00019052-200206000-00014

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

311-6

issue

3

eissn

1350-7540

issn

1473-6551

journal_volume

15

pub_type

杂志文章,评审
  • Magnetic resonance-guided focused ultrasound for movement disorders: clinical and neuroimaging advances.

    abstract:PURPOSE OF REVIEW:To describe the path of technological developments that have led to the actual application of MRI-guided focused ultrasound in multiple neurological disorders and to update the more recent technical advances in the field. An insight into the latest clinical achievements in movement disorders will be p...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章

    doi:10.1097/WCO.0000000000000840

    authors: Martínez-Fernández R,Pineda-Pardo JA

    更新日期:2020-08-01 00:00:00

  • Learning and memory: recent findings.

    abstract::Recent findings from neuroimaging, event-related potential and lesion investigations reflect a rapidly emerging view that the memory system is widely distributed throughout the cortex. It is clear that the pattern of cortical involvement during encoding and retrieval of memories is critically dependent on the nature a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200108000-00004

    authors: Bright P,Kopelman MD

    更新日期:2001-08-01 00:00:00

  • Cervicogenic causes of vertigo.

    abstract:PURPOSE OF REVIEW:Herein we discuss the recent literature concerning cervicogenic vertigo including vertigo associated with rotational vertebral artery syndrome, as well as whiplash and degenerative disturbances of the cervical spine. We conclude with a summary of progress regarding diagnostic methods for cervicogenic ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000161

    authors: Hain TC

    更新日期:2015-02-01 00:00:00

  • The various Charcot-Marie-Tooth diseases.

    abstract:PURPOSE OF REVIEW:This review focuses on recent advances in the diagnostic approaches and the underlying pathophysiological mechanisms of Charcot-Marie-Tooth (CMT) disease. We also discuss the emerging therapies for this hereditary neuropathy. RECENT FINDINGS:To date, numerous genes are implicated in CMT, and new gene...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328364c04b

    authors: Vallat JM,Mathis S,Funalot B

    更新日期:2013-10-01 00:00:00

  • Epilepsy classification: a cycle of evolution and revolution.

    abstract:PURPOSE OF REVIEW:This review presents the new terms and concepts proposed by the International League Against Epilepsy (ILAE) Classification Commission in 2010 to describe seizures and epilepsies. This is the first major revision in 21 years and reflects the rapid evolution in our understanding of the epilepsies. REC...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32835ee58e

    authors: Korff CM,Scheffer IE

    更新日期:2013-04-01 00:00:00

  • Neuropathology of variants of progressive supranuclear palsy.

    abstract:PURPOSE OF REVIEW:Neurodegenerative tauopathies, of which progressive supranuclear palsy (PSP) is one of the most common, are clinically heterogeneous, reflecting differences in distribution and biochemical composition of tau pathology. This review highlights the range of clinical and pathologic presentations of PSP an...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32833be924

    authors: Dickson DW,Ahmed Z,Algom AA,Tsuboi Y,Josephs KA

    更新日期:2010-08-01 00:00:00

  • Axonal Charcot-Marie-Tooth disease.

    abstract:PURPOSE OF REVIEW:The aim is to specify the genetic causes of dominantly and recessively inherited axonal forms of Charcot-Marie-Tooth disease (CMT) and review the biological basis for these disorders. RECENT FINDINGS:More than 10 genes that cause axonal CMT have been identified over the past decade. Many of these gen...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32834aa331

    authors: Shy ME,Patzkó A

    更新日期:2011-10-01 00:00:00

  • Early steps toward understanding neuronal communication.

    abstract:PURPOSE OF REVIEW:The computational power of the brain arises from the complex interactions between neurons. One straightforward method to quantify the strength of neuronal interactions is by measuring correlation and coherence. Efforts to measure correlation have been advancing rapidly of late, spurred by the developm...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000512

    authors: Snyder AC,Smith MA

    更新日期:2018-02-01 00:00:00

  • New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?

    abstract:PURPOSE OF REVIEW:Valproic acid (VPA) is one of the four first line antiepileptic drugs (AEDs). VPA is also an effective drug in migraine prophylaxis and in treatment of bipolar disorders. The use of VPA is limited by its two rare but potentially life-threatening side effects, teratogenicity and hepatotoxicity, and it ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000063774.81810.30

    authors: Isoherranen N,Yagen B,Bialer M

    更新日期:2003-04-01 00:00:00

  • Update on uveomeningoencephalitides.

    abstract:PURPOSE OF REVIEW:Uveomeningoencephalitides, commonly known as Vogt-Koyanagi-Harada (VKH) disease, are characterized by chronic bilateral granulomatous panuveitis involving the central nervous, auditory and integumentary systems. Visual prognosis is generally favourable, but outcomes in patients with VKH disease may va...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000169753.31321.4e

    authors: Sheu SJ

    更新日期:2005-06-01 00:00:00

  • Spinal dural arteriovenous fistula.

    abstract:PURPOSE OF REVIEW:To summarize clinical key points, diagnostic features, and results of imaging and therapy of spinal dural arteriovenous fistula (SDAVF). RECENT FINDINGS:SDAVF accounts for 70% of spinal arteriovenous malformation with an annual incidence of 5-10 cases per million. At least 80% of patients are male, a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000200547.22292.11

    authors: Koch C

    更新日期:2006-02-01 00:00:00

  • Myelin oligodendrocyte glycoprotein antibodies: How clinically useful are they?

    abstract:PURPOSE OF REVIEW:Serum IgG autoantibodies against the myelin oligodendrocyte glycoprotein (MOG) are present in atypical demyelinating disorders such as neuromyelitis optica spectrum disorders (NMOSD) or acute disseminated encephalomyelitis. Whereas the role of aquaporin-4 antibodies as diagnostic markers for NMOSD is ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000446

    authors: Reindl M,Jarius S,Rostasy K,Berger T

    更新日期:2017-06-01 00:00:00

  • The anaesthetic and intensive care of status epilepticus.

    abstract:PURPOSE OF REVIEW:Status epilepticus refractory to first and second-line anticonvulsants represents an outstanding challenge to the medical team. This review covers new insights into the anaesthetic and intensive care of status epilepticus. RECENT FINDINGS:In the anaesthetic treatment of status epilepticus, barbiturat...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328042bacb

    authors: Holtkamp M

    更新日期:2007-04-01 00:00:00

  • The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools.

    abstract:PURPOSE OF REVIEW:Neuroimaging in motor neuron disease (MND) has traditionally been seen as an academic tool with limited direct relevance to individualized patient care. This has changed radically in recent years as computational imaging has emerged as a viable clinical tool with true biomarker potential. This transit...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000569

    authors: Bede P,Querin G,Pradat PF

    更新日期:2018-08-01 00:00:00

  • Visual neglect.

    abstract:PURPOSE OF REVIEW:Left visual neglect is a frequent and dramatic consequence of right hemisphere lesions. Diagnosis is important because behavioural and pharmacological treatments are available. Furthermore, neglect raises important issues concerning the brain mechanisms of consciousness, perception and attention. REC...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32816aa3a3

    authors: Bartolomeo P

    更新日期:2007-08-01 00:00:00

  • Exotic and emerging viral encephalitides.

    abstract:PURPOSE OF REVIEW:The exotic and emerging viral encephalitides are caused by animal or human viruses and characterised by sudden unexpected outbreaks of neurological disease, usually in tropical and sub-tropical regions, but sometimes spreading to temperate areas. Although a wide range of viruses come within this label...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000073944.19076.56

    authors: Solomon T

    更新日期:2003-06-01 00:00:00

  • Stimulation of N-methyl-D-aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury.

    abstract:PURPOSE OF REVIEW:The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human traumatic brain injury (TBI) and stroke, along with preclinical findings of a persistent hypofunctional state of these receptors after brain injury, resulted in a new focus on NMDAR agonists, specifically those a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000612

    authors: Biegon A,Liraz-Zaltsman S,Shohami E

    更新日期:2018-12-01 00:00:00

  • Peripheral and central eye movement disorders.

    abstract::Continuing advances have rendered the neural control of eye movements one of the best understood motor systems, from molecules to complex behaviors. Nevertheless, new discoveries have required re-evaluation of established concepts, from the genetics of disorders that affect extraocular muscles to the way in which the ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200202000-00008

    authors: Szatmáry G,Leigh RJ

    更新日期:2002-02-01 00:00:00

  • Rasmussen's syndrome.

    abstract::Subacute focal encephalitis of Rasmussen involves cortical inflammatory infiltration which may on occasion be bilateral. The presence of anti-Glu R3 antibodies in some patients suggests that an autoimmune process may be involved. Although a small number of patients respond transiently to immunoglobulins and the condit...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章

    doi:

    authors: Dulac O

    更新日期:1996-04-01 00:00:00

  • Cochlear gene therapy.

    abstract:PURPOSE OF REVIEW:This review highlights recent advances in cochlear gene therapy over the past several years. Cochlear gene therapy has undergone tremendous advances over the past decade. Beginning with some groundbreaking work in 2005 documenting hair cell regeneration using virally mediated delivery of the mouse ato...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32834f038c

    authors: Lustig LR,Akil O

    更新日期:2012-02-01 00:00:00

  • The elusive promise of myostatin inhibition for muscular dystrophy.

    abstract:PURPOSE OF REVIEW:Recent terminations of clinical trials of myostatin inhibitors in muscular dystrophy have raised questions about the predictiveness of mouse models for this therapeutic strategy. RECENT FINDINGS:A variety of myostatin inhibitors have been developed for preclinical and clinical studies. These inhibito...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章

    doi:10.1097/WCO.0000000000000853

    authors: Wagner KR

    更新日期:2020-10-01 00:00:00

  • Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain.

    abstract::Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis. These include now well-recognized alterations of neuronal biochemical mar...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200206000-00004

    authors: Wolinsky JS,Narayana PA

    更新日期:2002-06-01 00:00:00

  • Treatment of idiopathic inflammatory myopathies.

    abstract:PURPOSE OF REVIEW:This article reviews the results of recent therapeutic trials in dermatomyositis, polymyositis, and inclusion body myositis and suggests an approach to treating patients with inflammatory myopathy. RECENT FINDINGS:We reviewed 10 double-blind, placebo-controlled therapeutic trials in patients with inf...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000093099.34793.40

    authors: Amato AA,Griggs RC

    更新日期:2003-10-01 00:00:00

  • Epidemiology of Parkinson's disease and akinetic syndromes.

    abstract::New reports of the incidence, prevalence and mortality of Parkinson's disease and parkinsonism are reviewed. Evidence for occupational and lifestyle risk factors and protective factors is updated. Recent genetic epidemiology studies of parkinsonism in twins and families, and studies that investigated imaging and physi...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200008000-00010

    authors: Tanner CM,Aston DA

    更新日期:2000-08-01 00:00:00

  • Toxic neuropathies and myopathies.

    abstract::This review first considers toxic neuropathies of recent interest, including those caused by antineoplastic and antiretroviral drugs, agents that affect methylation reactions, vitamin and herbal preparations, and certain occupational exposures. The discussion points out the interesting phenomenon of "coasting," the st...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199310000-00004

    authors: Kuncl RW,George EB

    更新日期:1993-10-01 00:00:00

  • Chlamydia pneumoniae infection of the central nervous system.

    abstract::Chlamydia pneumoniae is a common respiratory pathogen that is now being implicated in a number of chronic diseases. That the organism can infect vascular endothelium, macrophages and smooth muscle cells suggests that it may play a role in many systemic diseases. The present review focuses on the possibility that the c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200106000-00015

    authors: Yucesan C,Sriram S

    更新日期:2001-06-01 00:00:00

  • Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis.

    abstract:PURPOSE OF REVIEW:The aim of this study was to assess the seizure manifestations and risk of epilepsy in encephalitis associated with antibodies against neuronal cell-surface (autoimmune encephalitis) or myelin-associated antigens, and to review several chronic epileptic disorders, including Rasmussen's encephalitis, f...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000449

    authors: Spatola M,Dalmau J

    更新日期:2017-06-01 00:00:00

  • The influence of anxiety on ocular motor control and gaze.

    abstract:PURPOSE OF REVIEW:The influence of anxiety on ocular motor control and gaze has received less research attention than its effects on postural control and locomotion. This review summarizes research on trait anxiety, state anxiety, anxiety disorders, ocular motor reflexes, and gaze. It applies these findings to clinical...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000055

    authors: Staab JP

    更新日期:2014-02-01 00:00:00

  • Neuroimaging of drug resistance in epilepsy.

    abstract:PURPOSE OF REVIEW:Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the fu...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000072

    authors: Koepp MJ

    更新日期:2014-04-01 00:00:00

  • Central nervous system infections in the systemic vasculitides.

    abstract:PURPOSE OF REVIEW:Central nervous system infections are not uncommon in systemic vasculitides. Being vigilant of central nervous system infections as an alternative consideration, instead of systemic vasculitides per se, could prove to be lifesaving in certain circumstances. RECENT FINDINGS:Common pathogens, such as t...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3283013983

    authors: Ye S,Yang CD

    更新日期:2008-06-01 00:00:00