Neurodegeneration with brain iron accumulation.

abstract：PURPOSE OF REVIEW:Human ischemic stroke is a multistage disorder with different options for recovery. Imaging has opened a window to explore the pathophysiology and recovery mechanisms of ischemic stroke in vivo. RECENT FINDINGS:It was shown that in the acute phase, arterial recanalization and reperfusion are the most...

journal_title：Current opinion in neurology

authors： Seitz RJ

更新日期：2010-02-01 00:00:00

abstract：:The motoneuron has a strong ability to regenerate after injury. However, the problems of nerve cell survival after a proximal axotomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity during nerve fibre regrowth interfere with a good functional restitution. Current research h...

journal_title：Current opinion in neurology

authors： Carlstedt T

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cervical artery dissection (CeAD) is a major cause of ischemic stroke in young and middle-aged adults, although relatively uncommon in the community. Recent large collaborative projects have provided new insights into mechanisms and risk factors of CeAD. RECENT FINDINGS:Pathologic changes observed at...

journal_title：Current opinion in neurology

authors： Debette S

更新日期：2014-02-01 00:00:00

abstract：:Little progress has been made in the treatment outcome of patients with glioblastoma in the past 10 to 15 years, despite an aggressive multimodality regimen using surgery, radiation, and chemotherapy. New approaches, particularly molecular strategies, have become the clinicians' and scientists' hope for the future in ...

journal_title：Current opinion in neurology

authors： Yung WK

更新日期：1994-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Is multiple sclerosis (MS) a generalized disease of the central nervous system? Or put another way, is MS pathology primarily focal with global consequences or global with focal consequences? Consideration of this question depends on how you view it both spatially and temporally. In this review, we ad...

journal_title：Current opinion in neurology

authors： Chard D,Miller D

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to review sleep disturbances in different movement disorders, mainly Parkinson's disease, and highlight current concepts on merging the boundaries between movement disorders and dissociative states of being. RECENT FINDINGS:Since the observation that rapid eye movement sleep behavior disor...

journal_title：Current opinion in neurology

authors： Giannoccaro MP,Antelmi E,Plazzi G

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pa...

journal_title：Current opinion in neurology

authors： Gilhus NE

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH). RECENT FINDINGS:The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified a...

journal_title：Current opinion in neurology

authors： Mollan SP,Hoffmann J,Sinclair AJ

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic and often disabling neuropathy, which often responds to immune therapies including corticosteroids, plasma exchange, and high-dose intravenous immunoglobulin (IVIg). The reasons for choosing one of these therapies and the fa...

journal_title：Current opinion in neurology

authors： Nobile-Orazio E,Gallia F

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent advances in cochlear gene therapy over the past several years. Cochlear gene therapy has undergone tremendous advances over the past decade. Beginning with some groundbreaking work in 2005 documenting hair cell regeneration using virally mediated delivery of the mouse ato...

journal_title：Current opinion in neurology

authors： Lustig LR,Akil O

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the applicability of a framework of frontal lobe functioning to understand the sequelae of traumatic brain injury (TBI). RECENT FINDINGS:TBI research illustrates the need for improved phenotyping of TBI outcome. The functions of the frontal lobes are divisible into four distinct ...

journal_title：Current opinion in neurology

authors： Stuss DT

更新日期：2011-12-01 00:00:00

abstract：:Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to ...

journal_title：Current opinion in neurology

authors： Voisin T,Touchon J,Vellas B

更新日期：2003-12-01 00:00:00

abstract：:The population of pediatric patients with cerebrovascular disease presents a unique set of challenges to the neurosurgeon. The wide scope of pathology, including arteriovenous malformations, cavernous malformations and moyamoya disease, coupled with marked advances in diagnosis and treatment of these conditions over t...

journal_title：Current opinion in neurology

authors： Smith ER,Butler WE,Ogilvy CS

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Neurodegenerative tauopathies, of which progressive supranuclear palsy (PSP) is one of the most common, are clinically heterogeneous, reflecting differences in distribution and biochemical composition of tau pathology. This review highlights the range of clinical and pathologic presentations of PSP an...

journal_title：Current opinion in neurology

authors： Dickson DW,Ahmed Z,Algom AA,Tsuboi Y,Josephs KA

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The advent of novel techniques for tracing connections in vivo, such as diffusion tensor magnetic resonance imaging tractography, allows us, for the first time in the human brain, to study the microstructural integrity of white matter fibres and perform virtual dissections of large scale neurocognitiv...

journal_title：Current opinion in neurology

authors： Catani M

更新日期：2006-12-01 00:00:00

abstract：:Although theoretical reasons exist for believing that selegiline slows the progression of Parkinson's disease, this has not been shown in clinical trials. Selegiline improves the symptoms of Parkinson's disease, allowing the introduction of levodopa to be delayed in de-novo patients and, later, for levodopa to be used...

journal_title：Current opinion in neurology

authors： Hely MA,Morris JG

更新日期：1996-08-01 00:00:00

abstract：PURPOSE OF REVIEW:With the aging of the population, treatment of painful neuropathies is becoming more and more important for neurological practice. This short review highlights recent findings and current problems. RECENT FINDINGS:In addition to tricyclic antidepressants and gabapentin, the reliability of which is es...

journal_title：Current opinion in neurology

authors： Cruccu G

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The exotic and emerging viral encephalitides are caused by animal or human viruses and characterised by sudden unexpected outbreaks of neurological disease, usually in tropical and sub-tropical regions, but sometimes spreading to temperate areas. Although a wide range of viruses come within this label...

journal_title：Current opinion in neurology

authors： Solomon T

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Prospective and retrospective incidence cohort studies have been consistent in identifying an increased mortality in patients with epilepsy, although risk ratios vary considerably. Standardized mortality ratios in these populations range from 1.6 to 5.3, but they tend to be higher in studies in select...

journal_title：Current opinion in neurology

authors： Jallon P

更新日期：2004-04-01 00:00:00

abstract：:Magnetic resonance spectroscopy allows neurochemistry to be probed noninvasively in vivo. Recent advances in our understanding of the biochemical significance of the various neurochemicals that are observable allow a variety of pathologic states of relevance to encephalopathies and neurodegenerative disorders to be ob...

journal_title：Current opinion in neurology

authors： Jenkins BG,Kraft E

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients with brain tumors as well as neurologists involved in basic, clinical, and epidemiological research. This review summarizes what neurologists nee...

journal_title：Current opinion in neurology

authors： DeWitt JC,Mock A,Louis DN

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent progress in serological screening for paraneoplastic autoantibodies and diagnostic imaging techniques to detect malignancies has resulted in a broadening of the concept of paraneoplastic neurologic syndromes through the characterization of nonclassical clinical features. The goal of this articl...

journal_title：Current opinion in neurology

authors： Koike H,Tanaka F,Sobue G

更新日期：2011-10-01 00:00:00

abstract：:An increasing number of mutations in the CACNA1A gene have been identified, which are associated with a broad clinical spectrum, including familial hemiplegic migraine. Transfection studies and mouse model analyses are currently being undertaken to study the correlation between CACNA1A mutations and disease. ...

journal_title：Current opinion in neurology

authors： Kors EE,van den Maagdenberg AM,Plomp JJ,Frants RR,Ferrari MD

更新日期：2002-06-01 00:00:00

abstract：:Positron emission tomography, single photon emission computed tomography and magnetic resonance spectroscopy provide distinct, uncorrelated and sensitive indicators of brain tumors which can be used to improve differential diagnosis, biopsy guidance or therapy monitoring. New findings, including conflicting ethyl-cyst...

journal_title：Current opinion in neurology

authors： Slosman DO,Lazeyras F

更新日期：1996-12-01 00:00:00

abstract：:Slowly, advances are being made in the understanding and treatment of primary childhood brain tumors. The addition of chemotherapy has resulted in better survival for children with medulloblastoma. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy is increasingly being employed to tr...

journal_title：Current opinion in neurology

authors： Packer RJ

更新日期：1997-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent identification of mutations in five genes coding for proteins with putative or demonstrated glycosyltransferase activity has shed light on a novel mechanism responsible for muscular dystrophy. Abnormal glycosylation of alpha-dystroglycan appears to be a common finding in all these condition...

journal_title：Current opinion in neurology

authors： Muntoni F,Brockington M,Torelli S,Brown SC

更新日期：2004-04-01 00:00:00

abstract：:Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-ophthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biops...

journal_title：Current opinion in neurology

authors： Hooda BS,Finlay JL

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we summarize the evidence from human studies of the impairments to the structural, functional, and metabolic capacities in skeletal muscle in those with type 1 diabetes (T1D) - a condition known as diabetic myopathy. Given the importance of skeletal muscle for blood lipid and glucose management, ...

journal_title：Current opinion in neurology

authors： Monaco CMF,Perry CGR,Hawke TJ

更新日期：2017-10-01 00:00:00

abstract：:Autoimmune ataxic neuropathies are a subset of the sensory ataxic neuropathies which are characterized by ataxia as the dominant presenting feature. The major known causes of autoimmune ataxic neuropathies include sensory variants of the Guillain-Barré syndrome, including Miller-Fisher syndrome, subsets of immunoglobu...

journal_title：Current opinion in neurology

authors： O'Leary CP,Willison HJ

更新日期：1997-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In recent years, advances in the understanding of the regulatory mechanisms of the immune system has led to the development of new approaches for cancer treatment. Currently, immune checkpoint inhibitors are the first successful examples of this approach and several agents that target cytotoxic lympho...

journal_title：Current opinion in neurology

authors： Hottinger AF

更新日期：2016-12-01 00:00:00