Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.


PURPOSE OF REVIEW:This review will summarize new neuroimaging techniques, particularly MRI and PET imaging, that can be used to assess brain tumor growth and angiogenesis. RECENT FINDINGS:Glioma tumor vasculature is abnormal, and advances in MRI now permit visualization of the hemodynamic properties of gliomas including cerebral blood volume and blood flow, vascular permeability, and blood vessel diameter. New radiolabeled PET tracers have allowed more specific interrogation of glioma physiology such as hypoxia assessment or tumor proliferation rate. These two techniques are complementary and will likely yield important information on tumor response to therapy, particularly in the setting of antiangiogenic agents, which confound the interpretation of standard contrast-enhanced MRI scans. SUMMARY:These techniques may allow development of patient-specific therapy to improve outcome in patients with gliomas.


Curr Opin Neurol


Gerstner ER,Sorensen AG,Jain RK,Batchelor TT




Has Abstract


2008-12-01 00:00:00














  • Myelin repair strategies: a cellular view.

    abstract:PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Gallo V,Armstrong RC

    更新日期:2008-06-01 00:00:00

  • Neuromuscular problems in the ICU.

    abstract:PURPOSE OF REVIEW:Patients with acute life-threatening neuromuscular disease require close cooperation between neuromuscular and intensive care specialists to achieve the best possible outcomes. The problems encountered by these patients are different from those in traditional neuromuscular practice, and neurologists c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Damian MS,Srinivasan R

    更新日期:2017-10-01 00:00:00

  • Inflammatory muscle diseases.

    abstract::Dermatomyositis and polymyositis are treatable disorders of skeletal muscle. Despite their clinical similarities, they appear to have fundamentally different autoimmune origins. Inclusion body myositis, from its origins 30 years ago, has emerged as the commonest acquired myopathy of the elderly. Despite inflammatory c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Hilton-Jones D

    更新日期:2001-10-01 00:00:00

  • Neuroimaging insights into network-based neurodegeneration.

    abstract:PURPOSE OF REVIEW:Convergent evidence from a number of neuroscience disciplines supports the hypothesis that Alzheimer's disease and other neurodegenerative disorders progress along brain networks. This review considers the role of neuroimaging in strengthening the case for network-based neurodegeneration and elucidati...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Greicius MD,Kimmel DL

    更新日期:2012-12-01 00:00:00

  • The anaesthetic and intensive care of status epilepticus.

    abstract:PURPOSE OF REVIEW:Status epilepticus refractory to first and second-line anticonvulsants represents an outstanding challenge to the medical team. This review covers new insights into the anaesthetic and intensive care of status epilepticus. RECENT FINDINGS:In the anaesthetic treatment of status epilepticus, barbiturat...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Holtkamp M

    更新日期:2007-04-01 00:00:00

  • Central nervous system infections in children (bacterial, tubercular).

    abstract::Central nervous system infections are an important cause of childhood morbidity and mortality. This review discusses recent developments in diagnostic tests, management strategies, and prevention of bacterial and tubercular meningitis. ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Singhi PD,Singhi SC

    更新日期:1995-04-01 00:00:00

  • Chlamydia pneumoniae infection of the central nervous system.

    abstract::Chlamydia pneumoniae is a common respiratory pathogen that is now being implicated in a number of chronic diseases. That the organism can infect vascular endothelium, macrophages and smooth muscle cells suggests that it may play a role in many systemic diseases. The present review focuses on the possibility that the c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Yucesan C,Sriram S

    更新日期:2001-06-01 00:00:00

  • Disability following head injury.

    abstract::Disability following head injury varies depending on injury mechanism, neuropathology, and other factors, including medical complications. Mild head injury (Glasgow Coma Scale score 13-15) has been shown to have considerable variability in outcome. Some persons experience rapid symptom resolution whereas others contin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Macciocchi SN,Reid DB,Barth JT

    更新日期:1993-10-01 00:00:00

  • MRI in multiple sclerosis: clinical and research update.

    abstract:PURPOSE OF REVIEW:Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced MR sequences allows the characterization of diverse and complex pathological mechanisms, gra...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Inglese M,Petracca M

    更新日期:2018-06-01 00:00:00

  • Muscle regeneration: molecular aspects and therapeutic implications.

    abstract::With respect to diverse clinical applications for muscle regeneration, this paper discusses the latest markers for identifying skeletal muscle precursor cells in regenerating muscle, the implications of alternative sources of myogenic precursor cells and putative stem cells, and the current status of administration of...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Grounds MD

    更新日期:1999-10-01 00:00:00

  • Four birds with one stone? Reparative, neuroplastic, cardiorespiratory, and metabolic benefits of aerobic exercise poststroke.

    abstract:PURPOSE OF REVIEW:Converging evidence from animal models of stroke and clinical trials suggests that aerobic exercise has effects across multiple targets. RECENT FINDINGS:The subacute phase is characterized by a period of heightened neuroplasticity when aerobic exercise has the potential to optimize recovery. In anima...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Ploughman M,Kelly LP

    更新日期:2016-12-01 00:00:00

  • Maintaining high thrombectomy rates during pandemics.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review the current literature on endovascular treatment of acute ischemic stroke in the aftermath of the coronavirus disease 2019 (COVID-19) lockdown. RECENT FINDINGS:The outbreak of the COVID-19 has had effect of unprecedented magnitude on the social, economic and perso...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Dobrocky T,Kaesmacher J,Pereira VM,Gralla J,Fischer U

    更新日期:2021-02-01 00:00:00

  • Spinal cord lesions.

    abstract::Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Biering-Sørensen F,Hartkopp A

    更新日期:1995-12-01 00:00:00

  • Optic neuritis as a phase 2 paradigm for neuroprotection therapies of multiple sclerosis: update on current trials and perspectives.

    abstract:PURPOSE OF REVIEW:In multiple sclerosis as the most common inflammatory demyelinating disease in Western countries, major therapeutic success has been achieved with regard to strategies targeting immunological master switches. These approaches effectively reduce inflammatory disease activity but fail to address ongoing...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Aktas O,Albrecht P,Hartung HP

    更新日期:2016-06-01 00:00:00

  • New management algorithms in multiple sclerosis.

    abstract:PURPOSE OF REVIEW:Our current treatment algorithms include only IFN-β and glatiramer as available first-line disease-modifying drugs and natalizumab and fingolimod as second-line therapies. Today, 10 drugs have been approved in Europe and nine in the United States making the choice of therapy more complex. The purpose ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Sorensen PS

    更新日期:2014-06-01 00:00:00

  • Cervicogenic causes of vertigo.

    abstract:PURPOSE OF REVIEW:Herein we discuss the recent literature concerning cervicogenic vertigo including vertigo associated with rotational vertebral artery syndrome, as well as whiplash and degenerative disturbances of the cervical spine. We conclude with a summary of progress regarding diagnostic methods for cervicogenic ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Hain TC

    更新日期:2015-02-01 00:00:00

  • Genetics of Parkinson's disease.

    abstract:PURPOSE OF REVIEW:Parkinson's disease is the second most common neurodegenerative disorder and affects 2% of the population over the age of 60 years. Due to the increasing proportion of elderly individuals in developed countries, Parkinson's disease and related neurodegenerative disorders represent a growing burden on ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Gasser T

    更新日期:2005-08-01 00:00:00

  • Upper and lower extremity robotic devices for rehabilitation and for studying motor control.

    abstract:PURPOSE OF REVIEW:The successful motor rehabilitation of stroke, traumatic brain-injured and spinal cord-injured patients requires an intensive and task-specific therapy approach. Budget constraints limit a hand-to-hand therapy approach, so that intelligent machines may offer a solution to promote motor recovery and ob...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Hesse S,Schmidt H,Werner C,Bardeleben A

    更新日期:2003-12-01 00:00:00

  • Intra-arterial thrombolysis in acute stroke.

    abstract::A relatively small number of studies were published on the intra-arterial therapy of stroke in the past year. Those reports, however, do offer strong evidence for the feasibility and safety of this therapeutic approach. Partly on the basis of these data it has become evident that the intra-arterial thrombolytic therap...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Abou-Chebl A,Furlan AJ

    更新日期:2000-02-01 00:00:00

  • Respiratory failure because of neuromuscular disease.

    abstract:PURPOSE OF REVIEW:Understanding the mechanisms and abnormalities of respiratory function in neuromuscular disease is critical to supporting the patient and maintaining ventilation in the face of acute or chronic progressive impairment. RECENT FINDINGS:Retrospective clinical studies reviewing the care of patients with ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Howard RS

    更新日期:2016-10-01 00:00:00

  • Stimulation of N-methyl-D-aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury.

    abstract:PURPOSE OF REVIEW:The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human traumatic brain injury (TBI) and stroke, along with preclinical findings of a persistent hypofunctional state of these receptors after brain injury, resulted in a new focus on NMDAR agonists, specifically those a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Biegon A,Liraz-Zaltsman S,Shohami E

    更新日期:2018-12-01 00:00:00

  • The unique role of the trigeminal autonomic reflex and its modulation in primary headache disorders.

    abstract:PURPOSE OF REVIEW:The trigeminal autonomic reflex is a physiological reflex with an important protective function which also plays a role in pathophysiological conditions, such as primary headache. It is not understood whether the autonomic symptoms in trigeminal autonomic cephalalgias and migraine are the consequence ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Möller M,May A

    更新日期:2019-06-01 00:00:00

  • New potential leads in the biology and treatment of attention deficit-hyperactivity disorder.

    abstract:PURPOSE OF REVIEW:This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments. RECENT FINDINGS:The findings suggest that attention deficit-hyperactivity disorder is characterized by specific learning and c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Casey BJ,Nigg JT,Durston S

    更新日期:2007-04-01 00:00:00

  • Neurorehabilitation in multiple sclerosis: foundations, facts and fiction.

    abstract:PURPOSE OF REVIEW:This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments. RECENT FINDINGS:Several recent review documents have summarized the current position regarding neuroreha...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Thompson AJ

    更新日期:2005-06-01 00:00:00

  • Inflammatory disorders of muscle: progress in polymyositis, dermatomyositis and inclusion body myositis.

    abstract:PURPOSE OF REVIEW:To provide an update on the major advances in inflammatory myopathies. RECENT FINDINGS:Polymyositis is an uncommon disorder that can be misdiagnosed when the old, and never validated, criteria of Bohan and Peter are used. New diagnostic criteria were recently introduced, in which the MHC/CD8 complex ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Dalakas MC

    更新日期:2004-10-01 00:00:00

  • An update on aortic causes of ischemic stroke.

    abstract::In the past few years evidence that atherosclerotic disease of the aortic arch is probably an underestimate source of emboli, particularly moving thrombi in the lumen, has accumulated. Pathological studies, and more recently transesophageal echocardiographic studies, have shown that atherosclerotic disease of the aort...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Heinzlef O,Cohen A,Amarenco P

    更新日期:1997-02-01 00:00:00

  • The clinical and pathologic hallmarks of progressive supranuclear palsy.

    abstract::This article reviews recent studies evaluating the clinicopathologic markers of progressive supranuclear palsy, which have helped establish standardized clinical and pathologic diagnostic criteria. Although these criteria increase diagnostic accuracy, the clinical and pathologic overlap between progressive supranuclea...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Litvan I

    更新日期:1997-08-01 00:00:00

  • Drug-induced myopathies.

    abstract::Two major entities continue to be controversial in the field of clinical myotoxicity: the various myopathies that are induced by the cholesterol-lowering agents and the acute quadriplegic myopathy of intensive care. Both conditions are relatively common, but their pathogenesis is unclear. The problematic issues relate...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Argov Z

    更新日期:2000-10-01 00:00:00

  • New approaches to molecular therapy of brain tumors.

    abstract::Little progress has been made in the treatment outcome of patients with glioblastoma in the past 10 to 15 years, despite an aggressive multimodality regimen using surgery, radiation, and chemotherapy. New approaches, particularly molecular strategies, have become the clinicians' and scientists' hope for the future in ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Yung WK

    更新日期:1994-12-01 00:00:00

  • Mechanisms of cell death in neurodegenerative and retinal diseases: common pathway?

    abstract::The review intends to draw the attention of researchers working in retinal degenerations on the fact that classical apoptosis, for example, apoptosis triggering caspase activation, may not be the main pathway of cellular demise in this tissue.Former work already showed the difficulty of proving the activation of apopt...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Torriglia A,Jaadane I,Lebon C

    更新日期:2016-02-01 00:00:00