Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain.

abstract：PURPOSE OF REVIEW:The recent identification of mutations in five genes coding for proteins with putative or demonstrated glycosyltransferase activity has shed light on a novel mechanism responsible for muscular dystrophy. Abnormal glycosylation of alpha-dystroglycan appears to be a common finding in all these condition...

journal_title：Current opinion in neurology

authors： Muntoni F,Brockington M,Torelli S,Brown SC

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Our current treatment algorithms include only IFN-β and glatiramer as available first-line disease-modifying drugs and natalizumab and fingolimod as second-line therapies. Today, 10 drugs have been approved in Europe and nine in the United States making the choice of therapy more complex. The purpose ...

journal_title：Current opinion in neurology

authors： Sorensen PS

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In multiple sclerosis as the most common inflammatory demyelinating disease in Western countries, major therapeutic success has been achieved with regard to strategies targeting immunological master switches. These approaches effectively reduce inflammatory disease activity but fail to address ongoing...

journal_title：Current opinion in neurology

authors： Aktas O,Albrecht P,Hartung HP

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The funduscopic examination can be a technically difficult, and often omitted, portion of the neurologic examination, despite its great potential to influence patient care. RECENT FINDINGS:Medical practitioners are often first taught to examine the ocular fundus using a direct ophthalmoscope, however...

journal_title：Current opinion in neurology

authors： Rodenbeck SJ,Mackay DD

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 25 years, many autoantibodies directed against peripheral nerve glycan and protein antigens have been described. Principally through this area of research, significant advances have been achieved in the understanding of the pathophysiology of inflammatory neuropathies. More evidence cons...

journal_title：Current opinion in neurology

authors： Chavada G,Willison HJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Although cluster headache has traditionally been thought of as a vascular headache disorder, its periodicity suggests an involvement of central areas such as the hypothalamus. This review covers the past 3 years, which have seen remarkable progress in understanding the pathophysiology of circadian hea...

journal_title：Current opinion in neurology

authors： May A,Leone M

更新日期：2003-06-01 00:00:00

abstract：:Trauma to the developing brain constitutes an unexplored field. The few studies attempting to model and study paediatric head trauma, the leading cause of death and disability in the paediatric population, have revealed interesting aspects and potential targets for future research. One feature unique to the developing...

journal_title：Current opinion in neurology

authors： Felderhoff-Mueser U,Ikonomidou C

更新日期：2000-04-01 00:00:00

abstract：:This review first considers toxic neuropathies of recent interest, including those caused by antineoplastic and antiretroviral drugs, agents that affect methylation reactions, vitamin and herbal preparations, and certain occupational exposures. The discussion points out the interesting phenomenon of "coasting," the st...

journal_title：Current opinion in neurology

authors： Kuncl RW,George EB

更新日期：1993-10-01 00:00:00

abstract：:Neuropharmacology is aiding our understanding of the control of eye movements in at least three ways. First, neurotransmitters have been identified in the pathways that coordinate gaze. Second, the technique of pharmacologic inactivation has provided a powerful method to determine the contributions of populations of n...

journal_title：Current opinion in neurology

authors： Leigh RJ,Ramat S

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. RECENT FINDINGS:Recent twin studies have confirmed that NDDs show moderate-to-hi...

journal_title：Current opinion in neurology

authors： Posthuma D,Polderman TJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we summarize the evidence from human studies of the impairments to the structural, functional, and metabolic capacities in skeletal muscle in those with type 1 diabetes (T1D) - a condition known as diabetic myopathy. Given the importance of skeletal muscle for blood lipid and glucose management, ...

journal_title：Current opinion in neurology

authors： Monaco CMF,Perry CGR,Hawke TJ

更新日期：2017-10-01 00:00:00

abstract：:A long series of studies beginning with the pioneering experiments of Wiesel and Hubel [1] has shown that correct visual experience is crucial for the development of the visual system. Recent results suggest that neurotrophic factors of the nerve growth factor family might have a relevant role in mediating the effects...

journal_title：Current opinion in neurology

authors： Pizzorusso T,Maffei L

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the current literature on endovascular treatment of acute ischemic stroke in the aftermath of the coronavirus disease 2019 (COVID-19) lockdown. RECENT FINDINGS:The outbreak of the COVID-19 has had effect of unprecedented magnitude on the social, economic and perso...

journal_title：Current opinion in neurology

authors： Dobrocky T,Kaesmacher J,Pereira VM,Gralla J,Fischer U

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The field of new technologies for upper-limb rehabilitation is exploding. The review presents new trends and studies of effectiveness from recent literature regarding robots, virtual reality and telerehabilitation for neurorehabilitation of the upper limb. RECENT FINDINGS:There appears to be a greate...

journal_title：Current opinion in neurology

authors： Brochard S,Robertson J,Médée B,Rémy-Néris O

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Campylobacter jejuni is the most frequent agent of antecedent infection in an axonal variant of Guillain-Barré syndrome, acute motor axonal neuropathy, and anti-GM1 or anti-GD1a IgG antibody is also associated with acute motor axonal neuropathy. Molecular mimicry has been found between human GM1 gangl...

journal_title：Current opinion in neurology

authors： Yuki N,Odaka M

更新日期：2005-10-01 00:00:00

abstract：:In multifocal motor or sensorimotor neuropathy with persistent conduction block, most of the recent research has concerned treatment. Open trials show that intravenous immunoglobulin is effective, providing a rapid and often marked clinical improvement, accompanied by a significant reduction of conduction block in som...

journal_title：Current opinion in neurology

authors： Léger JM

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the fu...

journal_title：Current opinion in neurology

authors： Koepp MJ

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Precise localization of the epileptogenic zone is imperative for the success of resective surgery of drug-resistant epileptic patients. To decrease the number of surgical failures, clinical research has been focusing on finding new biomarkers. For the past decades, high-frequency oscillations (HFOs, 8...

journal_title：Current opinion in neurology

authors： Roehri N,Bartolomei F

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes currently available treatment options and treatment strategies, investigational treatments, and the importance of exercise for early Parkinson's disease. RECENT FINDINGS:The available treatment options for early Parkinson's disease have changed little in the past decade and inc...

journal_title：Current opinion in neurology

authors： Pahwa R,Lyons KE

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

journal_title：Current opinion in neurology

authors： Schofield TM,Leff AP

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments. RECENT FINDINGS:The findings suggest that attention deficit-hyperactivity disorder is characterized by specific learning and c...

journal_title：Current opinion in neurology

authors： Casey BJ,Nigg JT,Durston S

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cervical artery dissection (CeAD) is a major cause of ischemic stroke in young and middle-aged adults, although relatively uncommon in the community. Recent large collaborative projects have provided new insights into mechanisms and risk factors of CeAD. RECENT FINDINGS:Pathologic changes observed at...

journal_title：Current opinion in neurology

authors： Debette S

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune and inflammatory disease of the central nervous system (CNS) that causes neurological disability in young adults and that to date has no cure. Until now, expensive and only partially efficacious therapies have become available. For this reason, researchers, cli...

journal_title：Current opinion in neurology

authors： Mangas A,Coveñas R,Geffard M

更新日期：2010-06-01 00:00:00

abstract：:Stimulated by the impressive effect of interferon beta on magnetic resonance imaging-detected disease activity, the past year or so has seen a particular interest in the use of magnetic resonance imaging to monitor treatment. To be effective in this regard, there needs to be a high sensitivity and accuracy in detectin...

journal_title：Current opinion in neurology

authors： Miller DH

更新日期：1995-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced MR sequences allows the characterization of diverse and complex pathological mechanisms, gra...

journal_title：Current opinion in neurology

authors： Inglese M,Petracca M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Small vessel diseases of the brain are still clinically underrecognized whereas their burden is increasing steeply. The most frequent is acquired degenerative small vessel disease. Many hereditary or idiopathic small vessel diseases have also been identified, of which cerebral autosomal-dominant arter...

journal_title：Current opinion in neurology

authors： Ringelstein EB,Nabavi DG

更新日期：2005-04-01 00:00:00

abstract：:Subacute focal encephalitis of Rasmussen involves cortical inflammatory infiltration which may on occasion be bilateral. The presence of anti-Glu R3 antibodies in some patients suggests that an autoimmune process may be involved. Although a small number of patients respond transiently to immunoglobulins and the condit...

journal_title：Current opinion in neurology

authors： Dulac O

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pa...

journal_title：Current opinion in neurology

authors： Gilhus NE

更新日期：2012-10-01 00:00:00

abstract：:Primary germ-cell tumors of the central nervous system are rare neoplasms that are seen primarily in the pediatric age group. Because of their frequent location in the pituitary and suprasellar regions, they present with typical neuro-ophthalmologic and neuroendocrine symptoms. Sophisticated imaging and surgical biops...

journal_title：Current opinion in neurology

authors： Hooda BS,Finlay JL

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments. RECENT FINDINGS:Several recent review documents have summarized the current position regarding neuroreha...

journal_title：Current opinion in neurology

authors： Thompson AJ

更新日期：2005-06-01 00:00:00