Abstract:
PURPOSE OF REVIEW:Hyperglycemia is frequent in patients with cerebrovascular disease. This review article aims to summarize the recent evidence from observational studies that examined the adverse cerebrovascular effects of dysglycemic states as well as interventional studies assessing intensive management strategies for hyperglycemia. RECENT FINDINGS:In recent years, diabetes, prediabetic states and insulin resistance and their association with cerebrovascular disease were an important focus of research. The cerebrovascular consequences of these metabolic abnormalities were found to extend beyond ischemic stroke to covert brain infarcts, other structural brain changes and to cognitive impairment with and without dementia. Interventional studies did not reveal that more intensive management of chronic hyperglycemia and of hyperglycemia in the setting of acute stroke improves outcome. There is clear evidence, however, that the overall management of multiple risk factors and behavior modification in patients with dysglycemia may reduce the burden of cerebrovascular disease. SUMMARY:Observational studies reveal the growing burden and adverse cerebrovascular effects of dysglycemic states. Currently available interventional studies assessing more intensive strategies for the management of hyperglycemia did not prove, however, to be effective. We discuss the current evidence, pathophysiological considerations and management implications.
journal_name
Curr Opin Neuroljournal_title
Current opinion in neurologyauthors
Haratz S,Tanne Ddoi
10.1097/WCO.0b013e3283418fedsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
81-8issue
1eissn
1350-7540issn
1473-6551journal_volume
24pub_type
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journal_title:Current opinion in neurology
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doi:10.1097/00019052-200406000-00016
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journal_title:Current opinion in neurology
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abstract::A relatively small number of studies were published on the intra-arterial therapy of stroke in the past year. Those reports, however, do offer strong evidence for the feasibility and safety of this therapeutic approach. Partly on the basis of these data it has become evident that the intra-arterial thrombolytic therap...
journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0b013e3283374a39
更新日期:2010-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review the current literature on endovascular treatment of acute ischemic stroke in the aftermath of the coronavirus disease 2019 (COVID-19) lockdown. RECENT FINDINGS:The outbreak of the COVID-19 has had effect of unprecedented magnitude on the social, economic and perso...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0000000000000890
更新日期:2021-02-01 00:00:00
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-200010000-00006
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:1995-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/WCO.0b013e32833735cf
更新日期:2010-04-01 00:00:00
abstract::Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-199512000-00010
更新日期:1995-12-01 00:00:00
abstract::Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis. These include now well-recognized alterations of neuronal biochemical mar...
journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
doi:10.1097/00019052-200206000-00004
更新日期:2002-06-01 00:00:00
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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更新日期:2008-06-01 00:00:00
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doi:10.1097/WCO.0b013e32834c7eb9
更新日期:2011-12-01 00:00:00
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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更新日期:2005-06-01 00:00:00
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