An update on the leukodsytrophies.

abstract：PURPOSE OF REVIEW:Gadolinium-enhancement depicts blood-brain barrier disruption associated with new inflammatory MRI lesions in multiple sclerosis (MS) and is widely used for diagnosis and therapeutic monitoring. However, earlier and more specific markers of inflammation are urgently needed. RECENT FINDINGS:Susceptibi...

journal_title：Current opinion in neurology

authors： Hagens M,van Berckel B,Barkhof F

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of chemotherapy in low-grade glioma has been redefined with the long-term follow-up of the RTOG 9802, which investigated adjuvant procarbazine, CCNU, and vincristine (PCV) chemotherapy in addition to radiotherapy, and the results of EORTC trial 22033 in a similar patient population that compa...

journal_title：Current opinion in neurology

authors： van den Bent MJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the most significant advances concerning the neural correlates of decision-making with emphasis on those imaging studies investigating the neural implementation of evaluative judgment processes. This is done against the background of current concepts from the field of judgment and...

journal_title：Current opinion in neurology

authors： Volz KG,Schubotz RI,von Cramon DY

更新日期：2006-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

journal_title：Current opinion in neurology

authors： Bromley RL,Baker GA,Meador KJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pa...

journal_title：Current opinion in neurology

authors： Gilhus NE

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS:Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or di...

journal_title：Current opinion in neurology

authors： Draganski B,Lutti A,Kherif F

更新日期：2013-12-01 00:00:00

abstract：:Continuing advances have rendered the neural control of eye movements one of the best understood motor systems, from molecules to complex behaviors. Nevertheless, new discoveries have required re-evaluation of established concepts, from the genetics of disorders that affect extraocular muscles to the way in which the ...

journal_title：Current opinion in neurology

authors： Szatmáry G,Leigh RJ

更新日期：2002-02-01 00:00:00

abstract：:This is a review of chemotherapy options for patients with brain tumors, both at the time of initial diagnosis and at recurrence. Gliomas, the most common malignant brain tumors, represent the main focus of the review; chemotherapeutic options for supratentorial, brain stem, and optic track gliomas are discussed. ...

journal_title：Current opinion in neurology

authors： Galanis E,Buckner JC

更新日期：2000-12-01 00:00:00

abstract：:Ablative surgery and deep brain stimulation for Parkinson's disease can be performed in the thalamus, the pallidum and the subthalamic nucleus. The efficacy and safety of unilateral pallidotomy is well established. Deep brain stimulation has a lower morbidity and is preferred for bilateral surgery. The subthalamic nuc...

journal_title：Current opinion in neurology

authors： Krack P,Hamel W,Mehdorn HM,Deuschl G

更新日期：1999-08-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an urgent need for effective therapies to restore neurologic function and decrease disability following traumatic brain injury (TBI). Here, emerging findings on the mechanisms of post-TBI neural repair and regeneration, as well as therapeutic implications, are selectively reviewed. RECENT FI...

journal_title：Current opinion in neurology

authors： Werner JK,Stevens RD

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The last 5 years have seen the number of ultra-high field (UHF; 7 T and beyond) MRI scanners nearly double. Benefits include improved specificity, better sensitivity for signal-starved compounds, and the ability to detect, quantify, and monitor tumor activity and treatment effects. This is especially ...

journal_title：Current opinion in neurology

authors： Lupo JM,Li Y,Hess CP,Nelson SJ

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To give an overview of recent data on the use of skin biopsy as a diagnostic tool in neuropathies. RECENT FINDINGS:The sensitivity and specificity of skin biopsy in detecting small fiber neuropathy is supported by new data. In many patients with small fiber neuropathy, a treatable disorder can be ide...

journal_title：Current opinion in neurology

authors： Sommer C

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Herein we discuss the recent literature concerning cervicogenic vertigo including vertigo associated with rotational vertebral artery syndrome, as well as whiplash and degenerative disturbances of the cervical spine. We conclude with a summary of progress regarding diagnostic methods for cervicogenic ...

journal_title：Current opinion in neurology

authors： Hain TC

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The traditional focus of neurorehabilitaion has been on the patients' attention on their deficit, such that they should become aware of their problems and gain intentional control of compensatory strategies (descending approach). We review prism adaptation as one of the approaches that emphasize ascen...

journal_title：Current opinion in neurology

authors： Pisella L,Rode G,Farnè A,Tilikete C,Rossetti Y

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss aspects of cytokine networks in neuroinflammatory diseases and attempt to provide some explanation for our failures and successes in translating preclinical data to benefit patients with multiple sclerosis (MS). We will discuss innate cytokines such as tumor necrosis factor al...

journal_title：Current opinion in neurology

authors： Codarri L,Fontana A,Becher B

更新日期：2010-06-01 00:00:00

abstract：:Desmin-related myopathies are marked by accumulation of desmin, which is often familial and associated with cardiomyopathy. When multifocal this excess is characterized by inclusions such as cytoplasmic or spheroid bodies, when disseminated the excess is called granulofilamentous material. Excess of desmin might repre...

journal_title：Current opinion in neurology

authors： Goebel HH

更新日期：1997-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Neuroimaging in motor neuron disease (MND) has traditionally been seen as an academic tool with limited direct relevance to individualized patient care. This has changed radically in recent years as computational imaging has emerged as a viable clinical tool with true biomarker potential. This transit...

journal_title：Current opinion in neurology

authors： Bede P,Querin G,Pradat PF

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with asymptomatic carotid stenosis are at increased vascular risk but optimal treatment is controversial. We reviewed the current evidence for medical and surgical intervention in these patients. RECENT FINDINGS:Optimal medical treatment is the most important aspect of management of patients...

journal_title：Current opinion in neurology

authors： Redgrave JN,Rothwell PM

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperglycemia is frequent in patients with cerebrovascular disease. This review article aims to summarize the recent evidence from observational studies that examined the adverse cerebrovascular effects of dysglycemic states as well as interventional studies assessing intensive management strategies f...

journal_title：Current opinion in neurology

authors： Haratz S,Tanne D

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

journal_title：Current opinion in neurology

authors： Ai S,Klein RS

更新日期：2020-06-01 00:00:00

abstract：:Various functional imaging modalities can be applied in acute ischaemic stroke to identify functionally impaired, but morphologically preserved tissue (i.e. the penumbra), and to distinguish it from irreversibly damaged tissue. Flow thresholds for irreversible tissue destruction resulting in functional impairment, as ...

journal_title：Current opinion in neurology

authors： Heiss WD,Forsting M,Diener HC

更新日期：2001-02-01 00:00:00

abstract：:Recent positron emission tomography investigations found spreading oligemia in the early phases of a human migraine attack. During the headache phase, increased cerebral blood flow was found in cortical sensory association areas and unilaterally in the brainstem. The brainstem activation persisted after complete relie...

journal_title：Current opinion in neurology

authors： Diener HC,May A

更新日期：1996-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to review sleep disturbances in different movement disorders, mainly Parkinson's disease, and highlight current concepts on merging the boundaries between movement disorders and dissociative states of being. RECENT FINDINGS:Since the observation that rapid eye movement sleep behavior disor...

journal_title：Current opinion in neurology

authors： Giannoccaro MP,Antelmi E,Plazzi G

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Treatment response of brain tumours is typically evaluated with gadolinium-enhanced MRI using the Macdonald criteria. These criteria depend on changes in the area of enhancement. However, gadolinium enhancement of brain tumours primarily reflects impairment of the blood-brain barrier. RECENT FINDINGS...

journal_title：Current opinion in neurology

authors： Brandsma D,van den Bent MJ

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describe the role and advancements of MRI in the diagnosis and monitoring of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients treated with natalizumab. RECENT FINDINGS:MRI is the most sensitive paraclinical tool in the detection of PML lesions in natalizumab...

journal_title：Current opinion in neurology

authors： Wattjes MP,Barkhof F

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses recent advances in the understanding of clinical and genetic aspects of primary ataxias, including congenital, autosomal recessive, autosomal dominant, episodic, X-linked, and mitochondrial ataxias, as well as idiopathic degenerative and secondary ataxias. RECENT FINDINGS:Many ...

journal_title：Current opinion in neurology

authors： Teive HA,Ashizawa T

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Most patients suffering from muscular dystrophies can now obtain a precise diagnosis of their underlying molecular defect, but no efficient treatment to prevent disability and death. This review summarizes recent progress towards developing efficient treatments for these severe diseases. RECENT FINDI...

journal_title：Current opinion in neurology

authors： Skuk D,Vilquin JT,Tremblay JP

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aims of this article are to review emerging therapies for multiple sclerosis (MS) and to consider new approaches to assessment and achievement of treatment success in patients with this disease. RECENT FINDINGS:A number of disease-modifying therapies for MS, including oral agents, are in advanced...

journal_title：Current opinion in neurology

authors： Fox EJ,Rhoades RW

更新日期：2012-02-01 00:00:00

abstract：:Since the first successful attempts in 1990, human embryonic tissue transplantation has attracted the attention of multiple investigators and clinicians as a serious candidate therapy for Parkinson's disease. Although over two hundred patients have undergone the procedure, multiple issues and questions remain unresolv...

journal_title：Current opinion in neurology

authors： Tabbal S,Fahn S,Frucht S

更新日期：1998-08-01 00:00:00

abstract：:Selected topics related to rehabilitation of individuals with spinal cord lesions are reviewed and commented upon. A 10-week arm-cranking programme improved aerobic capacity and endurance in tetraplegics. Furthermore, endurance training and forced vital capacity were found to be positively correlated. Rowing had addit...

journal_title：Current opinion in neurology

authors： Biering-Sørensen F,Hartkopp A

更新日期：1995-12-01 00:00:00