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Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.

Abstract：

INTRODUCTION:Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS:We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS:Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within 3years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS:Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Ekman C,Gottsäter A,Lindblad B,Dahlbäck B

doi

10.1016/j.clinbiochem.2010.04.006

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

873-6

issue

10-11

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(10)00139-6

journal_volume

43

pub_type

杂志文章

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