Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method.

Abstract:

:A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, lambda max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 mug/ml and 8-30 mug/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.

journal_name

Indian J Pharm Sci

authors

Prabu SL,Shirwaikar A,Shirwaikar A,Kumar CD,Joseph A,Kumar R

doi

10.4103/0250-474X.40351

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

128-31

issue

1

eissn

0250-474X

issn

1998-3743

journal_volume

70

pub_type

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