Hypoglycemic Effect of the Methanol flower Extract of Piper Claussenianum and the Major Constituent 2',6'-dihydroxy-4'-methoxychalcone in Streptozotocin Diabetic Rats.

Abstract:

:Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels of rats treated with methanol extract were reduced from 318.4±28.1 mg/dl before treatment to 174.2±38.3 mg/dl after 12 days of treatment (P<0.05). Phytochemical studies were carried out on inflorescences methanol crude extract in order to investigate the possible metabolites responsible for the pharmacological properties of the extract. After chromatographic procedures, three flavonoids were isolated and characterized. The major compound 2',6'-dihydroxy-4'-methoxychalcone was also tested. Rats that received the chalcone content also displayed a reduction in blood glucose levels from 277.4±7.7 mg/dl before treatment to 158.8±9.2 mg/dl after 12 days of treatment (P<0.05). The results suggest this chalcone is one of the metabolite responsible for the blood glucose levels reduction in rats with streptozotocin-induced diabetes. The inflorescence crude extract of P. claussenianum was found to be composed mainly by flavonoids and may be a potential natural source of compounds with hypoglycemic properties.

journal_name

Indian J Pharm Sci

authors

Marques AM,Pereira SL,Paiva RA,Cavalcante CV,Sudo SZ,Tinoco LW,Moreira DL,Guimaraes EF,Sudo RT,Kaplan MA,Sudo GZ

doi

10.4103/0250-474x.156624

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

237-43

issue

2

eissn

0250-474X

issn

1998-3743

journal_volume

77

pub_type

杂志文章
  • A pharmacovigilance study of antihypertensive medicines at a South delhi hospital.

    abstract::The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. The study was conducted in medicine out patient department of 150-bed Majeedia Hospital at Hamdard University Campus in New Delhi. The study was conducted by way of one to one patient interview by a registered ph...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.56018

    authors: Hussain A,Aqil M,Alam MS,Khan MR,Kapur P,Pillai KK

    更新日期:2009-05-01 00:00:00

  • A Novel Metabolite from Aspergillus ochraceus JGI 25 Showing Cytotoxicity to Hela Cells.

    abstract::This study aims at the isolation of filamentous fungi, extraction of metabolites, and evaluation of the cytotoxic properties on HeLa cells and normal human lymphocytes. We isolated fungi from the soil by serial dilution method. One of the isolates was chosen and identified as Aspergillus ochraceus Wilhelm (Trichocomac...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Nadumane VK,Venkat P,Pal A,Dharod H,Shukla M,Prashanthi K

    更新日期:2013-09-01 00:00:00

  • HPLC method for simultaneous determination of impurities and degradation products in zonisamide.

    abstract::A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.58183

    authors: Vijayakumar EK,Dhore DM,Kumar M

    更新日期:2009-09-01 00:00:00

  • Spectrofluorimetric method for determination of duloxetine hydrochloride in bulk and pharmaceutical dosage forms.

    abstract::A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of duloxetine hydrochloride in pure and pharmaceutical dosage form. Duloxetine hydrochloride showed strong native fluorescence in 0.05 M acetic acid having excitation at 225 nm and emission at 340 nm. Effect of diff...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.44603

    authors: Prabu SL,Shahnawaz S,Kumar CD,Shirwaikar A

    更新日期:2008-07-01 00:00:00

  • Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats.

    abstract::Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rat...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.49141

    authors: Dhanabal SP,Mohan Marugaraja MK,Suresh B

    更新日期:2008-11-01 00:00:00

  • Simultaneous analysis and quantification of markers of manjisthadi churna using high performance thin layer chromatography.

    abstract::Manjisthadi churna has been traditionally used in the Ayurvedic system of medicine and by traditional medical practices of India to treat hyperlipidemia. A rapid, simple and accurate method with high performance thin layer chromatography has been developed to standardised Manjisthadi churna using rubiadin, sennoside a...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.113541

    authors: Patel VR,Patel RK

    更新日期:2013-01-01 00:00:00

  • A Validated HPLC Method for Zanamivir and its Application to In vitro Permeability Study in Caco-2 Culture Model.

    abstract::A simple HPLC method was developed and validated for the quantification of zanamivir in permeability studies using Caco-2 cell culture model. Chromatographic resolution was achieved using 98% (v/v) ultrapure water and 2% (v/v) acetonitrile as mobile phase with flow rate of 0.5 ml/min on a BDS Hypersil Cyano column (le...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.99015

    authors: Boonyapiwat B,Sarisuta N,Ma Y,Steventon GB

    更新日期:2011-09-01 00:00:00

  • In vivo Antimalarial Activities of Russelia Equisetiformis in Plasmodium Berghei Infected Mice.

    abstract::The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.164787

    authors: Ojurongbe O,Ojo JA,Adefokun DI,Abiodun OO,Odewale G,Awe EO

    更新日期:2015-07-01 00:00:00

  • Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.

    abstract::A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detect...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.41473

    authors: Jain N,Raghuwanshi R,Jain D

    更新日期:2008-03-01 00:00:00

  • Meltlets(®) of soy isoflavones: process optimization and the effect of extrusion spheronization process parameters on antioxidant activity.

    abstract::In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheroniza...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.119831

    authors: Deshmukh K,Amin P

    更新日期:2013-07-01 00:00:00

  • Antibacterial activity of essential oils from palmarosa, evening primrose, lavender and tuberose.

    abstract::Essential oils extracted from flower petals of palmarosa (Cymbopogon martini), evening primrose (Primula rosea), lavender (Lavandula angustifolia) and tuberose (Polianthus tuberosa) were tested for their antibacterial activities against gram-positive and gram-negative bacteria. Different concentrations of each essenti...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.54278

    authors: Lodhia MH,Bhatt KR,Thaker VS

    更新日期:2009-03-01 00:00:00

  • In vitro Antibacterial Activity of Aqueous and Ethanol Extracts of Aristolochia indica and Toddalia asiatica Against Multidrug-Resistant Bacteria.

    abstract::Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffec...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.174991

    authors: Venkatadri B,Arunagirinathan N,Rameshkumar MR,Ramesh L,Dhanasezhian A,Agastian P

    更新日期:2015-11-01 00:00:00

  • Enhancement of transdermal penetration and bioavailability of poorly soluble acyclovir using solid lipid nanoparticles incorporated in gel cream.

    abstract::The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron g...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Gide PS,Gidwani SK,Kothule KU

    更新日期:2013-03-01 00:00:00

  • Cytofectin amine head group modification and degree of liposome pegylation: factors influencing gene transfer.

    abstract::The effectiveness of liposome-mediated gene transfer methods hinges, in part, on the nature of the interaction between the DNA cargo and the liposomes. Here we have examined the effect of quaternization of the cytofectin cationic head group on this interaction and the effect of concentration of the biocompatible, prot...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.95613

    authors: Daniels A,Noor-Mahomed N,Singh M,Ariatti M

    更新日期:2011-07-01 00:00:00

  • Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone.

    abstract::Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51944

    authors: Prajapati ST,Patel LD,Patel DM

    更新日期:2009-01-01 00:00:00

  • Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method.

    abstract::A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, lambda max of esomeprazole and domperidone respecti...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.40351

    authors: Prabu SL,Shirwaikar A,Shirwaikar A,Kumar CD,Joseph A,Kumar R

    更新日期:2008-01-01 00:00:00

  • Spectrophotometric estimation of olmesartan medoxomil and hydrochlorothiazide in tablet.

    abstract::A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan me...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.62245

    authors: Rote AR,Bari PD

    更新日期:2010-01-01 00:00:00

  • Synthesis and Antiviral Studies of Novel N-Sulphonamidomethyl piperazinyl Fluoroquinolones.

    abstract::A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.57293

    authors: Selvam P,Rathore P,Karthikumar S,Velkumar K,Palanisamy P,Vijayalakhsmi S,Witvrouw M

    更新日期:2009-07-01 00:00:00

  • Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives.

    abstract::A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.84603

    authors: Selvam P,Murugesh N,Chandramohan M,Pannecouque C,DE Clercq E

    更新日期:2010-11-01 00:00:00

  • Selective HPLC method development for soy phosphatidylcholine Fatty acids and its mass spectrometry.

    abstract::A novel, efficient and simple approach for soy phosphatidylcholine analysis according to its fatty acid composition was studied with reverse-phase high-performance liquid chromatography. The reverse-phase high-performance liquid chromatography analysis was performed isocratically using UV detector and simple mobile ph...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.117435

    authors: Jangle RD,Galge RV,Patil VV,Thorat BN

    更新日期:2013-05-01 00:00:00

  • Fluorimetric quantification of brimonidine tartrate in eye drops.

    abstract::A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good corr...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sunitha G,Bhagirath R,Alapati VR,Ramakrishna K,Subrahmanyam CV,Anumolu PD

    更新日期:2013-11-01 00:00:00

  • Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets by RP-HPLC.

    abstract::A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.43006

    authors: Tian DF,Tian XL,Tian T,Wang ZY,Mo FK

    更新日期:2008-05-01 00:00:00

  • Stability-indicating Reversed-phase Liquid Chromatographic Method for Simultaneous Determination of Losartan Potassium and Ramipril in Tablets.

    abstract::A stability-indicating reversed-phase liquid chromatographic method has been developed and validated for simultaneous determination of losartan potassium and ramipril. Separations were achieved using a C(18) column with mobile phase consisting of acetonitrile and (0.2% v/v, pH 2.5) aqueous trifluoroacetic acid (45:55,...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.106061

    authors: Kollipara S,Bende G,Bansal Y,Saha R

    更新日期:2012-05-01 00:00:00

  • Inhalational system for Etoposide liposomes: formulation development and in vitro deposition.

    abstract::Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.100240

    authors: Parmar JJ,Singh DJ,Lohade AA,Hegde DD,Soni PS,Samad A,Menon MD

    更新日期:2011-11-01 00:00:00

  • Optimization of Physical and Nutritional Parameters for Hyaluronidase Production by Streptococcus mitis.

    abstract::The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. The effects of initial pH, incubation temperature and time, inoculum level and age of inoculum were studied. The maximu...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.45412

    authors: Sahoo S,Panda PK,Mishra SR,Nayak A,Dash SK,Ellaiah P

    更新日期:2008-09-01 00:00:00

  • Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.

    abstract::Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Viswanathan V,Phadatare AG,Mukne A

    更新日期:2014-05-01 00:00:00

  • Antioxidant and Antimicrobial Activity of Alpinia officinarum.

    abstract::Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.62233

    authors: Srividya AR,Dhanabal SP,Misra VK,Suja G

    更新日期:2010-01-01 00:00:00

  • Reverse phase high performance liquid chromatographic method for the analysis of letrozole in pharmaceutical dosage forms.

    abstract::A rapid and sensitive reverse phase high performance liquid chromatographic method is depicted for the qualitative and quantitative assay of letrozole in pharmaceutical dosage forms. Letrozole was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and phosphate buffer (pH 7.8)...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.43019

    authors: Laha TK,Patnaik RK,Sen S

    更新日期:2008-05-01 00:00:00

  • Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles.

    abstract::In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. The structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, UV, IR, ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.40331

    authors: Nagalakshmi G

    更新日期:2008-01-01 00:00:00

  • Antibacterial Activity of Mangrove Leaf Extracts against Human Pathogens.

    abstract::The antibacterial activity of leaf extract of mangroves, namely, Rhizophora mucronata, Sonneratia alba and Exoecaria agallocha from Chorao island, Goa was investigated against human bacterial pathogens Staphylococcus aureus, Streptococcus sp., Salmonella typhi, Proteus vulgaris and Proteus mirabilis. As compared to aq...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.107068

    authors: Sahoo G,Mulla NS,Ansari ZA,Mohandass C

    更新日期:2012-07-01 00:00:00