Preparation of evodiamine solid dispersions and its pharmacokinetics.

Abstract:

:In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K(30) with different enriched samples of evodiamine to PVP K(30) ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion system in comparison with that in enriched samples of evodiamine or physical mixtures. The increase of the dissolution rate was evidently related to the ratio of evodiamine to PVP K(30). The solid dispersion system (enriched samples of evodiamine/PVP K(30)= 1/6, w/w) gave the highest dissolution rate: about 27.7-fold higher than that of enriched samples of evodiamine in hard capsules. Powder X-ray diffraction studies showed that enriched samples of evodiamine presented a total chemical stability after its preparation as solid dispersions. In vivo administration studies indicated that solid dispersions of evodiamine in hard capsules had a higher C(max) and a shorter T(max) than those of physical mixture in hard capsules, and the differences of C(max) and T(max) between them were significant. These results suggest that solid dispersions of evodiamine in hard capsules has a notably faster and greater absorption rate than enriched samples of evodiamine in physical mixture hard capsule and corresponds with the in vitro dissolution.

journal_name

Indian J Pharm Sci

authors

Xu H,Zhang T,Yang H,Xiao X,Bian Y,Si D,Liu C

doi

10.4103/0250-474X.93511

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

276-81

issue

3

eissn

0250-474X

issn

1998-3743

pii

IJPhS-73-276

journal_volume

73

pub_type

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