Abstract:
:A variety of cellular proteins have been found to bind to related DNA sequences in the enhancer elements of the human immunodeficiency virus, the kappa immunoglobulin gene, the class I major histocompatibility complex gene, and the beta-interferon gene. Recently, lambda gt11 gene expression cloning using ligated oligonucleotide probes complementary to these DNA binding motifs has been performed. An identical cDNA clone encoding a cellular protein, referred to as HIV-EP1, MBP-1, or PRDII-BF1, that binds to each of these sequences has been identified. This cDNA potentially encodes a 298-kDa cellular protein with two widely separated zinc finger binding domains, each of which binds to the same DNA sequence. As part of an effort to examine the chromosomal organization of cellular genes encoding transcription factors, we report the chromosomal mapping of the gene encoding this zinc finger protein (ZNF40) to chromosome 6p22.3-24.
journal_name
Genomicsjournal_title
Genomicsauthors
Gaynor RB,Muchardt C,Diep A,Mohandas TK,Sparkes RS,Lusis AJdoi
10.1016/0888-7543(91)90371-ksubject
Has Abstractpub_date
1991-04-01 00:00:00pages
758-61issue
4eissn
0888-7543issn
1089-8646journal_volume
9pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somat...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1372
更新日期:1993-09-01 00:00:00
abstract::SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic domain, and a 3' proline-rich region. Recent results suggest that SHIP2 and SHIP1 act downstream of various receptor...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5995
更新日期:1999-12-01 00:00:00
abstract::Four highly conserved members of the skeletal protein 4.1 gene family encode a diverse array of protein isoforms via tissue-specific transcription and developmentally regulated alternative pre-mRNA splicing. In addition to the prototypical red blood cell 4.1R (human gene symbol EPB41,) these include two homologues tha...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5537
更新日期:1998-12-01 00:00:00
abstract::Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1340
更新日期:1994-07-01 00:00:00
abstract::For genetic linkage analysis of Japanese flounder, 160 doubled haploids (DH) were artificially produced using mitotic gynogenesis and were genotyped for 458 simple sequence repeat (SSR) markers, 101 of which show distortional segregation. The genetic linkage map was constructed by modifying recombination fractions bet...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2017.08.006
更新日期:2018-01-01 00:00:00
abstract::Non-coding RNA is no longer considered to be "junk" DNA, based on evidence uncovered in recent decades. In particular, the important role played by natural antisense transcripts (NATs) in regulating the expression of genes is receiving increasing attention. However, the regulatory mechanisms of NATs remain incompletel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.011
更新日期:2019-03-01 00:00:00
abstract::In response to nutrient deprivation, the ubiquitous Gram-negative soil bacterium Myxococcus xanthus undergoes a well-characterized developmental response, resulting in the formation of a multicellular fruiting body. The center of the fruiting body consists of myxospores; surrounding this structure are rod-shaped perip...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.09.008
更新日期:2020-03-01 00:00:00
abstract::Imbalanced protease activity has long been recognized in the progression of disease states such as cancer and inflammation. Serpins, the largest family of endogenous protease inhibitors, target a wide variety of serine and cysteine proteases and play a role in a number of physiological and pathological states. The exp...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.03.017
更新日期:2006-08-01 00:00:00
abstract::The rice genome annotation has been greatly improved in recent years, largely due to the availability of full length cDNA sequences derived from many tissues. Among those yet to be studied is the aleurone layer, which produces hydrolases for mobilization of seed storage reserves during seed germination and post germin...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.10.007
更新日期:2014-01-01 00:00:00
abstract::A cluster of genes coding for proteins of the extracellular matrix (ECM) containing sequence motifs essential for integrin-receptor interactions is located on HSA4q21 and on BTA6, within the critical region of a quantitative trait locus (QTL) affecting milk protein production. Genes within this cluster are involved in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.03.005
更新日期:2004-08-01 00:00:00
abstract::We have characterized three terminal deletions of the long arm of the X chromosome. Southern analysis using Xq27/q28 probes suggests that two of the deletions have breakpoints near the fragile site at Xq27.3. Flow karyotype analysis provides an estimate of 12 X 10(6) bp for the size of the deleted region. We have not ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(87)90028-0
更新日期:1987-12-01 00:00:00
abstract::Fine mapping followed by candidate gene analysis of erd - a canine hereditary retinal degeneration characterized by aberrant photoreceptor development - established that the disease cosegregates with a SINE insertion in exon 4 of the canine STK38L/NDR2 gene. The mutation removes exon 4 from STK38L transcripts and is p...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.09.003
更新日期:2010-12-01 00:00:00
abstract::The gene encoding human carboxyl ester lipase (CEL), including 1628 bp of the 5'-flanking region, has been isolated and characterized from two overlapping lambda phage clones. The gene spans 9832 bp and contains 11 exons interrupted by 10 introns. The exons range in size from 88 to 204 bp, except for the last exon, wh...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90134-e
更新日期:1992-07-01 00:00:00
abstract::The general strategies of phototransduction in vertebrates and invertebrates share many similarities, but differ significantly in their underlying molecular machinery. The CDS gene encodes the CDP-diacylglycerol synthase (CDS) enzyme and is required for phototransduction in Drosophila. Using a bioinformatic approach, ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5610
更新日期:1999-01-01 00:00:00
abstract::Full-length coding sequences of two novel human cadherin cDNAs were obtained by sequence analysis of several EST clones and 5' and 3' rapid amplification of cDNA ends (RACE) products. Exons for a third cDNA sequence were identified in a public-domain human genomic sequence, and the coding sequence was completed by 3' ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6305
更新日期:2000-09-15 00:00:00
abstract::The genes encoding human U2 small nuclear RNA are arrayed in tandem (the RNU2 locus) and have undergone concerted evolution for >35 Myr. Tandem organization of repetitive sequences may facilitate recombination that underlies concerted evolution, but could risk instability. Since DNA methylation plays a crucial role in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6052
更新日期:1999-12-15 00:00:00
abstract::Palmitoyl-protein thioesterase (PPT) is a small glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins. We recently reported mutations in PPT in patients with infantile neuronal ceroid lipofuscinosis (INCL), a severe neurodegenerative disorder (J. Vesa et al., 1995, Nature 376: 58...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0292
更新日期:1996-06-15 00:00:00
abstract::We report a comprehensive comparative analysis of human and mouse olfactory receptor (OR) genes encoding OR37 subtypes to determine the repertoire, chromosomal organization, and relatedness of these genes. Two OR37 clusters were found in both mouse (chromosome 4) and human (chromosome 9); with five genes in cluster I ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00116-2
更新日期:2003-09-01 00:00:00
abstract::Grapsoidea and Ocypodoidea, two of the most abundant and economically important groups in Brachyura, are of great commercial value to fisheries and aquaculture. However, the taxonomy of Ocypodoidea and Grapsoidea has long been highly disputed. Previous studies have investigated this problem through phylogenetic analys...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.012
更新日期:2020-01-01 00:00:00
abstract::RNA helicase A is an enzyme that possesses both RNA and DNA helicase activities. In this report, we describe the isolation of a mouse cDNA encoding RNA helicase A. The deduced amino acid sequence derived from mouse RNA helicase A cDNA exhibits 87 and 47% identity to its human and Drosophila homologs, respectively. Usi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5139
更新日期:1998-02-01 00:00:00
abstract::We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was appr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90282-6
更新日期:1989-05-01 00:00:00
abstract::Hereditary congenital facial paresis (HCFP) belongs to the family of congenital cranial dysinnervation disorders and is characterized by an isolated dysfunction of the facial nerve (nVII). While genetic defects have been identified for several members of this disease family, genes underlying congenital facial paresis ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.03.007
更新日期:2005-07-01 00:00:00
abstract::The complexity of the somatic embryogenesis (SE) transcriptome suggests that numerous molecules are involved. To understand better the functional genomics of complex molecular systems during this important reprogramming process, we used bioinformatics and a pathway database to construct a draft network based on transc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.07.007
更新日期:2007-11-01 00:00:00
abstract::A full-length cDNA coding for mouse plasminogen has been isolated and characterized. The cDNA is 2720 bp in length (excluding the poly(A) tail) and contains a 24-bp 5' noncoding region, an open reading frame of 2436 bp, and a 3' noncoding region of 257 bp. The open reading frame codes for 812 amino acids and includes ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90225-j
更新日期:1990-09-01 00:00:00
abstract::The gene encoding activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, was isolated from a murine B cell lymphoma line, CH12F3-2, induced by combined stimulation of TGF-beta, IL-4, and CD40L. We have isolated the human orthologue of mouse AID cDNA, which has an open reading frame of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6268
更新日期:2000-08-15 00:00:00
abstract::We have isolated a human cDNA encoding a protein of 334 amino acids that shows 96% identity in amino acid sequence to murine cytosolic malate dehydrogenase. Heart and skeletal muscle expressed this gene most highly among the adult human tissues examined by Northern blot analysis. By fluorescence in situ hybridization,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0087
更新日期:1996-02-15 00:00:00
abstract::It is usually assumed that co-expressed genes suggest co-regulation in the underlying regulatory network. Determining sets of co-expressed genes is an important task, based on some criteria of similarity. This task is usually performed by clustering algorithms, where the genes are clustered into meaningful groups base...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2017.06.009
更新日期:2017-10-01 00:00:00
abstract::Deletions giving rise to Duchenne muscular dystrophy (DMD) and the less severe Becker muscular dystrophy (BMD) occur in the same large gene on the short arm of the human X chromosome. We present a molecular mechanism to explain the clinical difference in severity between DMD and BMD patients who bear partial deletions...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(88)90113-9
更新日期:1988-01-01 00:00:00
abstract::Because of the conservation of the ubiquitin coding sequence and the number of transcriptionally active genes and reverse-transcribed pseudogenes, it has not been possible to use ubiquitin cDNA clones to map the functional ubiquitin genes. The UBB and UBC polyubiquitin genes have previously been mapped by the use of s...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1108
更新日期:1994-02-01 00:00:00
abstract::Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome architecture and epigenetic factors, but their relationship is still unknown. In this study, we isolated promoter CGIs susceptible and resistant to aberrant methylation induct...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2011.06.003
更新日期:2011-09-01 00:00:00