Abstract:
:We report a comprehensive comparative analysis of human and mouse olfactory receptor (OR) genes encoding OR37 subtypes to determine the repertoire, chromosomal organization, and relatedness of these genes. Two OR37 clusters were found in both mouse (chromosome 4) and human (chromosome 9); with five genes in cluster I and three (mouse) and seven genes (human) in cluster II. The pronounced diversity of noncoding sequence regions in both genomic loci indicates a long-term coexistence of the two clusters and the genes within the clusters. In contrast, the coding regions, particularly of genes in cluster I, showed remarkably high sequence identity, a feature quite unique for OR genes. The conservation of only the coding sequences indicates that OR37 may be under negative selection pressure and suggests that the OR37 receptor family may be tuned to recognize distinct sets of signaling molecules. A comparison of mouse and human OR37 gene clusters revealed that genes in cluster I are highly related within each species whereas genes in cluster II are highly related across species. These data reflect a unique and complex evolutionary history of the OR37 family.
journal_name
Genomicsjournal_title
Genomicsauthors
Hoppe R,Breer H,Strotmann Jdoi
10.1016/s0888-7543(03)00116-2subject
Has Abstractpub_date
2003-09-01 00:00:00pages
355-64issue
3eissn
0888-7543issn
1089-8646pii
S0888754303001162journal_volume
82pub_type
杂志文章相关文献
GENOMICS文献大全abstract::The DBA/2J inbred strain of mice is used extensively in hearing research, yet little is known about the genetic basis for its early onset, progressive hearing loss. To map underlying genetic factors we analyzed recombinant inbred strains and linkage backcrosses. Analysis of 213 mice from 31 BXD recombinant inbred stra...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.06.007
更新日期:2008-10-01 00:00:00
abstract::Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1340
更新日期:1994-07-01 00:00:00
abstract::PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42/EKMDA2 distally and O327hb/O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We se...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90215-e
更新日期:1992-05-01 00:00:00
abstract::A genome-wide view of sequence mutability in mice is still limited, although biologists usually assume the same scenario for mice as for humans. In this study, we examined the sequence context in the local environment of 482,528 mouse single nucleotide polymorphisms (SNPs). We found that CpG-containing short sequences...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.09.012
更新日期:2006-01-01 00:00:00
abstract::Inborn errors of mitochondrial beta-oxidation cause ectopic fat accumulation, particularly in the liver. Fatty liver is associated with insulin resistance and predisposes to hepatic fibrosis. The factors underlying the pathophysiological consequences of hepatic fat accumulation have remained poorly defined. Gene expre...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.08.004
更新日期:2007-12-01 00:00:00
abstract::To investigate the molecular mechanism of silkworm resistance to BmNPV infection, we constructed a near-isogenic line (BC8) with BmNPV resistance using highly resistant (NB) and highly susceptible parental strains (306). We investigated variations in the gene expression in the midguts of BmNPV-infected BC8 and 306 at ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.02.004
更新日期:2013-04-01 00:00:00
abstract::Four highly conserved members of the skeletal protein 4.1 gene family encode a diverse array of protein isoforms via tissue-specific transcription and developmentally regulated alternative pre-mRNA splicing. In addition to the prototypical red blood cell 4.1R (human gene symbol EPB41,) these include two homologues tha...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5537
更新日期:1998-12-01 00:00:00
abstract::The Duchenne muscular dystrophy locus is remarkable in that it shows a high mutation rate and the majority of mutations found are deletions. These deletions are generated as meiotic as well as mitotic events and occur preferentially in the central region of the gene. Nothing is known so far about the mechanisms involv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90484-v
更新日期:1991-05-01 00:00:00
abstract::LRP1B is a novel candidate tumor suppressor gene that is inactivated by genetic and transcript alterations in nearly 50% of non-small-cell lung cancer cell lines. The gene-encoded protein is highly homologous to the gigantic lipoprotein receptor-related protein 1 (LRP1) that belongs to the family of low-density lipopr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6331
更新日期:2000-10-15 00:00:00
abstract::The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource for long-range mapping of this region. A large fraction of the hybrids (approximately 90%) retained...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1383
更新日期:1993-09-01 00:00:00
abstract::A gene for autosomal recessive juvenile parkinsonism (ARJP; HGMW-approved symbol PARK2; MIM 600116) has recently been mapped to a 17-cM interval on chromosome 6q25.2-q27. We here report an inbred family with ARJP showing a perfect cosegregation with null allele for D6S305, which is a marker within the ARJP locus. We a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5196
更新日期:1998-04-01 00:00:00
abstract::Human genomic mapping has been greatly advanced by the independent development of three new methods: large DNA fragment cloning in yeast artificial chromosomes, amplification from complex DNAs of human specific segments by Alu-PCR, and high-resolution localization of complex DNA probes by fluorescent in situ hybridiza...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90148-l
更新日期:1992-07-01 00:00:00
abstract::Specific language impairment (SLI) is defined as failure to acquire normal language skills despite adequate intelligence and environmental stimulation. Although SLI disorders are often heritable, the genetic basis is likely to involve a number of risk factors. This study describes a 7-year-old girl carrying an inherit...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2005.04.002
更新日期:2005-08-01 00:00:00
abstract::S-lac lectins are a family of soluble lactose-binding proteins thought to function in the control of cell growth. We now report the chromosomal mapping of two members of the family, termed L-14-I and L-14-II, to the q12-q13 region of human chromosome 22, suggesting the possibility of a cluster of genes for lactose-bin...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1078
更新日期:1993-02-01 00:00:00
abstract::Nematodes are responsible for causing severe diseases in plants, humans and other animals. Infection is associated with the release of Excretory/Secretory (ES) proteins into host cytoplasm and interference with the host immune system which make them attractive targets for therapeutic use. The identification of ES prot...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.03.007
更新日期:2019-05-01 00:00:00
abstract::Amaranth has been proposed as an exceptional alternative for food security and climate change mitigation. Information about the distribution, abundance, or specificity of miRNAs in amaranth species is scare. Here, small RNAs from seedlings under control, drought, heat, and cold stress conditions of the Amaranthus hypo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.11.027
更新日期:2021-01-01 00:00:00
abstract::The gene for X-linked nephrogenic diabetes insipidus (NDI), a disorder which, if untreated, causes severe dehydration, mental retardation, and possibly death in affected males, has been mapped recently to the Xq28 band through demonstration of linkage to the DX552 locus and other DNA markers (N. Knoers et al., 1987, C...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90352-2
更新日期:1989-04-01 00:00:00
abstract::We cloned and characterized a genomic DNA fragment including the deletion junction of a chronic granulomatous disease patient with a 25-kb deletion extending to the 5' two-thirds of CYBB. The 3' breakpoint of the deletion exists in exon 7 of CYBB. A LINE-1 element lies at 5 kb upstream of CYBB in normal persons, and t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5510
更新日期:1998-10-15 00:00:00
abstract::This paper describes an efficient procedure for selecting large numbers of unique-sequence or very low repeat-sequence probes from recombinant phage libraries. Probes were selected from the Charon 21A library LL21NS02 (made from DNA from human chromosome 21) in a multistep process in which (1) inserts from LL21NS02 we...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90092-x
更新日期:1989-07-01 00:00:00
abstract::We have reported that a novel c-Myc binding protein, AMY-1, stimulated the transcription activity of c-Myc and was translocated from the cytoplasm to the nucleus in a c-Myc-dependent manner. AMY-1 works as an inducer of human K562 cell differentiation upon induction of AraC. To characterize the expression or functiona...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00006-5
更新日期:2003-02-01 00:00:00
abstract::Here, we present the first complete genome sequence of brucellaphage Tbilisi (Tb) and compared it with that of Pr, a broad host-range brucellaphage recently isolated in Mexico. The genomes consist of 41,148 bp (Tb) and 38,253 bp (Pr), they differ mainly in the region encoding structural proteins, in which the genome o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2012.01.001
更新日期:2012-04-01 00:00:00
abstract::Sp4H is a semi-dominant mutation that maps to mouse chromosome 1. Heterozygous mice exhibit white spotting of the belly, whereas the fate of the homozygous embryos is unknown. We have previously shown that the entire coding region of the Pax3 gene is deleted in the Sp4H mutant. In this study, we have analyzed the fate...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0267
更新日期:1996-06-01 00:00:00
abstract::The transforming growth factor beta (TGF-beta) superfamily is a family of multifunctional cytokines that transduce signals via serine/threonine kinase receptors. Recent studies revealed that Mothers against dpp (Mad) in Drosophila and its homologs play important roles in the intracellular signal transduction of the se...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5149
更新日期:1998-02-15 00:00:00
abstract::Physical maps can be constructed by "fingerprinting" a large number of random clones and inferring overlap between clones when the fingerprints are sufficiently similar. E. Lander and M. Waterman (Genomics 2: 231-239, 1988) gave a mathematical analysis of such mapping strategies. The analysis is useful for comparing v...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80086-2
更新日期:1995-03-01 00:00:00
abstract::We describe the isolation and characterization of a human gene (CLCN3) and its murine homologue (Clcn3) sharing significant sequence and structural similarities with all previously identified members of the voltage-gated chloride channel (ClC) family. This gene is expressed primarily in tissues derived from neuroectod...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1015
更新日期:1995-05-01 00:00:00
abstract::Previous studies identified the gene encoding the erythrocyte membrane protein 4.2 (Epb4.2) as a candidate for the mouse mutation pallid (pa); Epb4.2 genetically colocalized near pa on mouse Chromosome 2, and a truncated Epb4.2 transcript was present in tissues derived from pallid mice. We report here evidence that Ep...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4764
更新日期:1997-06-15 00:00:00
abstract::Recently, we reported genetic linkage in Pima Indians between the acute insulin response to an intravenous glucose challenge and the short tandem repeat marker D1S198, indicative of a genetic element in this region that controls the phenotypic variation in the first phase of insulin secretion. As a first step to isola...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4504
更新日期:1997-01-15 00:00:00
abstract::To understand the pattern of gene expression in mouse myeloid progenitor cells, we carried out a genome-wide analysis of gene expression in mouse bone marrow Gr-1(+) cells using SAGE and GLGI techniques. We identified 22,033 unique SAGE tags with quantitative information from 73,869 collected SAGE tags. Among these un...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6633
更新日期:2001-10-01 00:00:00
abstract::The puffer fish, Fugu rubripes (Fugu), has been proposed as a model vertebrate genome. We have characterized two putative G-protein-coupled receptor encoding genes, FCB1A and FCB1B, obtained by degenerate PCR and low-stringency hybridization of a Fugu genomic library. These two genes show high homology to the human ca...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0406
更新日期:1996-08-01 00:00:00
abstract::Portions of 16 chromosome 21 NotI linking clones were sequenced. These linking clone sequences represent sequence-tagged restriction sites that are potentially useful for finding genes and for finer genome mapping and sequencing. All of the clones were G+C rich (54 to 83%). CpG and GpC dinucleotide frequencies were ve...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1455
更新日期:1993-11-01 00:00:00