Mapping of aldose reductase gene sequences to human chromosomes 1, 3, 7, 9, 11, and 13.

Abstract:

:Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization. By in situ hybridization analysis, sequences were localized to human chromosomes 1q32-q42, 3p12, 7q31-q35, 9q22, 11p14-p15, and 13q14-q21. As a putative functional AR gene has been mapped to chromosome 7 and a putative pseudogene to chromosome 3, the sequences on the other seven chromosomes may represent other active genes, non-aldose reductase homologous sequences, or pseudogenes.

journal_name

Genomics

journal_title

Genomics

authors

Bateman JB,Kojis T,Heinzmann C,Klisak I,Diep A,Carper D,Nishimura C,Mohandas T,Sparkes RS

doi

10.1006/geno.1993.1372

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

560-5

issue

3

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(83)71372-8

journal_volume

17

pub_type

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