Abstract：
:Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to assess disease-dependent regulatory mechanisms of c-Met/HGF receptor (c-Met) activation in the facial motoneurons of G93A mice. Using double transgenic mice expressing HGF and mutated SOD1(G93A) (G93A/HGF), we showed that phosphorylation of c-Met tyrosine residues at positions 1230, 1234 and 1235 (phospho-Tyr), and thereby its activation, was slightly evident in G93A and highly obvious in G93A/HGF mice (but absent in WT and HGF-Tg mice). Phosphorylation of the c-Met serine residue at position 985 (phospho-Ser), a residue involved in the negative regulation of its activation, was evident in WT and HGF-Tg mice. Protein phosphatase 2A (PP2A), which is capable of dephosphorylating c-Met phospho-serine, is upregulated in the facial motoneurons of G93A and G93A/HGF mice compared with WT and HGF-Tg mice. Thus, c-Met activation is reciprocally regulated by phosphorylation between c-Met serine and tyrosine residues through PP2A induction in the presence or absence of mutant SOD1 expression, and HGF functions more efficiently in ALS and ALS-related diseases.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kadoyama K,Funakoshi H,Ohya-Shimada W,Nakamura T,Matsumoto K,Matsuyama S,Nakamura Tdoi
10.1016/j.neures.2009.06.016subject
Has Abstractpub_date
2009-10-01 00:00:00pages
194-200issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(09)00207-7journal_volume
65pub_type
杂志文章abstract：:Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.06.007
更新日期：2009-10-01 00:00:00
abstract：:Spinal reflex arcs mediated by low threshold afferents between the brachioradialis (BR) and flexor carpi radialis (FCR) were studied in eleven healthy human subjects using a post-stimulus time-histogram method. Electrical conditioning stimuli (ES) to the radial nerve branch innervating BR with the intensity below the ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.03.001
更新日期：2016-09-01 00:00:00
abstract：:Injury to the central nervous system causes glial reactions, which eventually lead to the formation of a glial scar and inhibit axonal regeneration. The present study aimed to reduce the extent of glial scar formation in injured cerebral cortex using heparin hexasaccharide (6-mer) and octasaccharide (8-mer). A single ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.01.007
更新日期：2004-05-01 00:00:00
abstract：:The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backpro...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.06.009
更新日期：2005-10-01 00:00:00
abstract：:Social categorization plays an important role in provoking the victim's responses to aggressive interactions. Pioneering studies suggested that uncertainty in the perpetrator's hostile intention influences whether ingroup favoritism or the black sheep effect (ingroup strictness) will be manifested to a greater extent....
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.01.011
更新日期：2016-07-01 00:00:00
abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.06.013
更新日期：2006-10-01 00:00:00
abstract：:Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the β- and γ-secretases generates Aβ peptides; however, the alternate cleavage of APP by the α- and γ-secretases decreases Aβ production. We previously reported th...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.11.004
更新日期：2014-02-01 00:00:00
abstract：:The neuroprotective effect of nicotine via nicotinic acetylcholine receptor (nAChR) has been reported in differentiated PC12 cells. We examined the effects of nerve growth factor (NGF) and nicotine on the expressions of the nAChR subunits alpha3, alpha5, alpha7, beta2, beta3 and beta4, in PC12 cells using Northern blo...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00064-4
更新日期：1999-12-01 00:00:00
abstract：:Stem cells represent a potential cellular resource in the development of regenerative medicine approaches to the treatment of pathologies in which specific cells are degenerated or damaged by genetic abnormality, disease, or injury. Securing sufficient supplies of cells suited to the demands of cell transplantation, h...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.11.011
更新日期：2016-06-01 00:00:00
abstract：:We investigated brain activity in 3-5-year-old preschoolers as they listened to connected speech stimuli in Japanese (first language), English (second language), and Chinese (a rarely exposed, foreign language) using near-infrared spectroscopy. Unlike the younger preschoolers who had been exposed to English for almost...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.02.004
更新日期：2012-05-01 00:00:00
abstract：:Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...
journal_title：Neuroscience research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neures.2006.09.004
更新日期：2007-01-01 00:00:00
abstract：:Light-induced changes in the input resistance (Rin) of external, luminosity (i.e. H1) type horizontal cell (HC) perikarya were studied by the bridge-balance method in light-adapted and dark-adapted retinae of carp. Changes in input resistance (delta Rin) induced by short-(460 nm) and long-wavelength (674 nm) flashes, ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01133-9
更新日期：1997-01-01 00:00:00
abstract：:Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(84)80008-5
更新日期：1984-04-01 00:00:00
abstract：:Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90021-3
更新日期：1994-07-01 00:00:00
abstract：:Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.010
更新日期：2015-05-01 00:00:00
abstract：:Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). CO is generated by heme oxygenase during the conversion of heme to biliverdin. In this study, we raised an antiserum against the ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01018-8
更新日期：1996-03-01 00:00:00
abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.009
更新日期：2008-07-01 00:00:00
abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.09.010
更新日期：2005-01-01 00:00:00
abstract：:A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.05.009
更新日期：2006-09-01 00:00:00
abstract：:We developed a new method to visualize the myeloarchitecture in fresh slices, and investigated the properties of the functional neural connections around the boundary between the primary auditory cortex (area 41) and area 18a in rat cerebral slices. A fresh slice illuminated by near-vertical light was observed with a ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00059-2
更新日期：2003-06-01 00:00:00
abstract：:Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential l...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.01.011
更新日期：2007-05-01 00:00:00
abstract：:This study was designed to evaluate the anticonvulsant effects of imperatorin (a furanocoumarin isolated from fruits of Angelica archangelica) in the mouse maximal electroshock seizure threshold model. The threshold for electroconvulsions in mice was determined at several times: 15, 30, 60 and 120 min after i.p. admin...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.05.004
更新日期：2007-09-01 00:00:00
abstract：:Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(84)90036-1
更新日期：1984-10-01 00:00:00
abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.10.001
更新日期：2005-02-01 00:00:00
abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00897-2
更新日期：1995-05-01 00:00:00
abstract：:The influence of the phosphorylation dephosphorylation states on the gamma-aminobutyric acid (GABA) transporter activity of synaptic plasma membranes (SPM) was studied by using either specific phosphatase inhibitors or activators. Calyculin A and okadaic acid (phosphatase 1 and phosphatase 2A inhibitors) inhibited the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00107-2
更新日期：1999-01-01 00:00:00
abstract：:Communication in the central nervous system (CNS) occurs through initiation and propagation of action potentials at excitable domains along axons. Action potentials generated at the axon initial segment (AIS) are regenerated at nodes of Ranvier through the process of saltatory conduction. Proper formation and maintena...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2016.09.010
更新日期：2017-03-01 00:00:00
abstract：:It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.04.004
更新日期：2004-08-01 00:00:00
abstract：:Interleukin-6 (IL-6, human recombinant) promoted the survival of catecholaminergic neurons from fetal and postnatal rat midbrains as assessed by an immunohistochemical staining for tyrosine hydroxylase (TH) in culture using a chemically defined medium. The maximal dose of IL-6 for the cell survival of postnatal P15 ra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90039-f
更新日期：1992-05-01 00:00:00
