Abstract:
:Storage and release of proteins from granules forms the basis of cellular functions as diverse as cell mediated cytotoxicity, neuronal communication, activation of muscle fibres, and release of hormones or digestive enzymes from endocrine and exocrine glands, such as the pancreas. Serglycin is the major intracellular proteoglycan of haematopoietic cells. Serglycin is important for localization of proteins in granules of different haematopoietic cell types. Previous reports have indicated a role for serglycin in granule formation and localization of zymogens in granules of the exocrine pancreas in rat. We here present data showing that serglycin is not present at the protein level in human or murine pancreas. Furthermore, the amount and localization of three exocrine pancreas zymogens (amylase, trypsinogen, and carboxypeptidase A) is not affected by the absence of serglycin in a serglycin knock-out mouse model.
journal_name
Eur J Cell Bioljournal_title
European journal of cell biologyauthors
Niemann CU,Cowland JB,Ralfkiaer E,Abrink M,Pejler G,Borregaard Ndoi
10.1016/j.ejcb.2009.03.002subject
Has Abstractpub_date
2009-08-01 00:00:00pages
473-9issue
8eissn
0171-9335issn
1618-1298pii
S0171-9335(09)00227-1journal_volume
88pub_type
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