当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CELL BIOLOGY期刊下所有文献 > CA125/MUC16 interacts with Src family kinases, and over-expression of its C-terminal fragment in human epithelial cancer cells reduces cell-cell adhesion.

CA125/MUC16 interacts with Src family kinases, and over-expression of its C-terminal fragment in human epithelial cancer cells reduces cell-cell adhesion.

Abstract：

:MUC16/CA125 is over-expressed in human epithelial tumors including ovarian, breast and some other carcinomas. The purpose of this study is to investigate how cell surface MUC16 is functionally involved in tumor progression, with a special focus on the role of its cytoplasmic tail. Forced expression of C-terminal MUC16 fragment (MUC16C) in epithelial cancer cells increased cell migration. We found that MUC16C directly interacted with Src family kinases (SFKs). Notably, localizations of E-cadherin and β-catenin at the cell-cell contacts were more diffuse in MUC16C transfectants compared with mock transfectants. Furthermore, MUC16C transfectants showed reduced Ca(2+)-dependent cell-cell adhesion, but the treatment of cells with PP2, a SFKs inhibitor, restored this. Because cell surface MUC16 is also associated with the E-cadherin/β-catenin complex, the over-expression of MUC16 and its interaction with SFKs may enhance SFKs-induced deregulation of E-cadherin. Thus, our results suggest a role for cell surface MUC16 in cell-cell adhesion of epithelial cancer cells.

journal_name

Eur J Cell Biol

journal_title

European journal of cell biology

authors

Akita K,Tanaka M,Tanida S,Mori Y,Toda M,Nakada H

doi

10.1016/j.ejcb.2013.10.005

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

257-63

issue

8-9

eissn

0171-9335

issn

1618-1298

pii

S0171-9335(13)00064-2

journal_volume

92

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CELL BIOLOGY文献大全
  • LIM kinase 1: evidence for a role in the regulation of intracellular vesicle trafficking of lysosomes and endosomes in human breast cancer cells.

    abstract：:LIM kinase (LIMK) plays a critical role in stimulus-induced remodeling of the actin cytoskeleton by linking signals from the Rho family GTPases to changes in cofilin activity. Recent studies have shown an important role for LIMK1 signaling in tumor cell invasion through regulating actin dynamics. In this study, we inv...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1078/0171-9335-00382

    authors： Nishimura Y,Yoshioka K,Bernard O,Himeno M,Itoh K

    更新日期：2004-08-01 00:00:00

  • Identification of PEX33, a novel component of the peroxisomal docking complex in the filamentous fungus Neurospora crassa.

    abstract：:The docking complex of peroxisomal matrix protein import is composed of PEX13 and PEX14 in all species analyzed so far, whereas only yeast appears to possess an additional component, PEX17. In this report we isolated PEX14 complexes of Neurospora crassa. Among the complex constituents, one protein designated as PEX33 ...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2010.07.003

    authors： Managadze D,Würtz C,Wiese S,Schneider M,Girzalsky W,Meyer HE,Erdmann R,Warscheid B,Rottensteiner H

    更新日期：2010-12-01 00:00:00

  • Regulation of human enteric α-defensins by NOD2 in the Paneth cell lineage.

    abstract：:Human enteric α-defensins (HD5 and HD6), major antimicrobial peptides produced by Paneth cells in the intestine, play important roles in intestinal innate immunity. Since their expression is decreased in Crohn's disease (CD), with decreased expression being more pronounced in the presence of NOD2 mutations, it would b...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2014.10.007

    authors： Tan G,Zeng B,Zhi FC

    更新日期：2015-01-01 00:00:00

  • Expression of keratinocyte biomarkers is governed by environmental biomechanics.

    abstract：:In solid body tissues, environmental biomechanics is indispensable for tissue homeostasis. While characteristics of homeostasis include morphogenesis, proliferation and differentiation, the influences through biomechanics in corneal keratinocytes are poorly understood. Here we show for the first time that corneal kera...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2011.08.005

    authors： Eberwein P,Steinberg T,Schulz S,Zimmermann D,Accardi R,Beck D,Reinhard T,Tomakidi P

    更新日期：2011-12-01 00:00:00

  • The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.

    abstract：:Centaurin alpha-1 is a high-affinity PtdIns(3,4,5)P3-binding protein enriched in brain. Sequence analysis indicates centaurin alpha-1 contains two pleckstrin homology domains, ankyrin repeats and an Arf GAP homology domain, placing it in the AZAP family of phosphoinositide-regulated Arf GAPs. Other members of this fam...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1078/0171-9335-00416

    authors： Thacker E,Kearns B,Chapman C,Hammond J,Howell A,Theibert A

    更新日期：2004-10-01 00:00:00

  • Identification of two types of beta-COP vesicles in the Golgi complex of rat spermatids.

    abstract：:In the present study, immunoelectron microscopy was used to characterize two types of coated vesicles at the trans Golgi reticulum (TGR) of rat early spermatids. Most of the coated vesicles and buds had a 18.4 +/- 0.5 nm thick electron-dense coat. The size of the vesicles without the coat was 102.6 +/- 3.6 nm. This co...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Martínez-Menárguez JA,Geuze HJ,Ballesta J

    更新日期：1996-10-01 00:00:00

  • Genes involved in Dictyostelium discoideum sexual reproduction.

    abstract：:Macrocyst formation in the cellular slime moulds is a sexual process induced under dark and humid conditions. Normal development life cycle in these organisms involves proliferation by cell division and, upon starvation, formation of multicellular aggregates and fruiting bodies, consisting of spores and stalk cells. M...

    journal_title：European journal of cell biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejcb.2006.05.012

    authors： Urushihara H,Muramoto T

    更新日期：2006-09-01 00:00:00

  • An 18-bp element in the 5' untranslated region of the Drosophila beta 2 tubulin mRNA regulates the mRNA level during postmeiotic stages of spermatogenesis.

    abstract：:During Drosophila spermatogenesis transcriptional activity is mainly restricted to premeiotic stages. Translation during sperm morphogenesis, however, proceeds for several days, requiring a high stability for mRNAs translated postmeiotically. We studied expression of the Drosophila beta 2 tubulin gene, which is expres...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Michiels F,Buttgereit D,Renkawitz-Pohl R

    更新日期：1993-10-01 00:00:00

  • Lysosomal Ca2+ release channel TRPML1 regulates lysosome size by promoting mTORC1 activity.

    abstract：:Lysosomal Ca2+ release channel TRPML1 has been suggested to regulate lysosome size by activating calmodulin (CaM). To further understand how TRPML1 and CaM regulate lysosome size, in this study, we report that inhibiting mTORC1 causes enlarged lysosomes, and the recovery of enlarged lysosomes is suppressed by inhibiti...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2019.05.001

    authors： Yang Y,Xu M,Zhu X,Yao J,Shen B,Dong XP

    更新日期：2019-06-01 00:00:00

  • Mitochondrial matrix localization of a protein altered in mutants resistant to the microtubule inhibitor podophyllotoxin.

    abstract：:Specific antibodies to a protein designated P1 (Mr approximately equal to 63,000), which is specifically altered in mutants resistant to the microtubule inhibitor podophyllotoxin, bind to mitochondria in cells of various vertebrate and invertebrate species (Eur. J. Cell Biol. 44, 278-285 (1987); Can. J. Biochem. Cell ...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Gupta RS,Austin RC

    更新日期：1987-12-01 00:00:00

  • Actin-rich structures formed during the invasion of cultured cells by infective forms of Trypanosoma cruzi.

    abstract：:Previous work has shown that Trypanosoma cruzi extracellular amastigotes as well as metacyclic trypomastigotes infect cultured cells in a highly specific parasite form-cell type interaction. In this work we have investigated the mode of interaction of both forms with HeLa and Vero cells using scanning electron and con...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/S0171-9335(99)80093-4

    authors： Procópio DO,Barros HC,Mortara RA

    更新日期：1999-12-01 00:00:00

  • Competence for nuclear replication and the NOR-chromosomes of Allium cepa L.

    abstract：:Autotetraploid (4n = 32) cells were induced in Allium cepa L. root meristems by successively treating with a multipolarizing agent in anaphase (carbetamide) and an inhibitor of cell plate formation in telophase (caffeine). This treatment produced cells with their 32 chromosomes distributed in more than two nuclei. Dur...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Panzera F,Giménez-Abián MI,López-Sáez JF,Giménez-Martín G,Cuadrado A,Cánovas JL,De la Torre C

    更新日期：1997-01-01 00:00:00

  • The human breast cancer cell line MDA-MB231 produces an aromatase stimulating activity.

    abstract：:Extraovarian estrogen production is localized mainly in stromal vascular cells from adipose tissue, which contain the aromatase activity necessary for the conversion of androgens to estrogens. Induction of aromatase activity in these cells by glucocorticoids occurs only in the presence of a serum factor, the propertie...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Schmidt M,Löffler G

    更新日期：1994-02-01 00:00:00

  • Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis.

    abstract：:Herein we report that Gts1p fused with green-fluorescent protein (GFP) is localized in the cortical actin patch besides nuclei in yeast and the cortical Gts1p changed its position together with the patch depending on the cell-cycle phase, while nuclear Gts1p accumulated predominantly in the budding phase. Whereas Gts1...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2007.02.005

    authors： Yaguchi S,Shen H,Tsurugi K

    更新日期：2007-05-01 00:00:00

  • Oligomerization supports transport of a mutant secretory protein out of the endoplasmic reticulum.

    abstract：:To examine the transport of the single subunits of the glycoprotein complex gp80 (clusterin, apolipoprotein J), a marker protein for apical exocytosis and main secretory product of Madin-Darby canine kidney (MDCK) cells, several mutant cDNAs were constructed and expressed in the fibroblastic baby hamster kidney (BHK-2...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Losch A,Henkel K,Wagner M,Urban J,Koch-Brandt C

    更新日期：1996-02-01 00:00:00

  • Sorting out the multiple roles of Fas ligand.

    abstract：:Fas ligand can both be used by the immune system to initiate cell death, and be used by non-lymphoid cells to evade death. Recent work has shown that Fas ligand is differentially sorted in different cell types. Here we present the viewpoint that the differential sorting plays an important part in determining the role ...

    journal_title：European journal of cell biology

    pub_type： 杂志文章,评审

    doi：10.1078/0171-9335-00077

    authors： Bossi G,Stinchcombe JC,Page LJ,Griffiths GM

    更新日期：2000-08-01 00:00:00

  • Uridine, but not cytidine can sustain growth of Ehrlich ascites tumor cells in glucose-deprived medium with altered proliferation kinetics.

    abstract：:Cell cycle kinetics and energy metabolism of Ehrlich ascites tumor cells grown in glucose-deprived medium supplemented with uridine, were investigated in order to extend our knowledge about the significance of the metabolic conversion of glucose for cell cycle progression of these cells. Viability (dye exclusion test)...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Linker W,Löffler M,Schneider F

    更新日期：1985-03-01 00:00:00

  • Expression pattern of Drosophila translin and behavioral analyses of the mutant.

    abstract：:Translin is an evolutionarily conserved approximately 27-kDa protein that binds to specific DNA and RNA sequences and has diverse cellular functions. Here, we report the cloning and characterization of the translin orthologue from the fruit fly Drosophila melanogaster. Under protein-denaturing conditions, purified Dro...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2006.11.005

    authors： Suseendranathan K,Sengupta K,Rikhy R,D'Souza JS,Kokkanti M,Kulkarni MG,Kamdar R,Changede R,Sinha R,Subramanian L,Singh K,Rodrigues V,Rao BJ

    更新日期：2007-03-01 00:00:00

  • Biogenesis and cytochemistry of unspecialized peroxisomes in root cortical cells of Yucca torreyi L.

    abstract：:Microbodies containing bipyramidal crystalline nucleoid inclusions occur within every cortical cell in roots of Yucca torreyi. Reaction product deposition attributable to catalase, glycolate oxidase, and urate oxidase activities are cytochemically localized to Yucca root microbodies and classifies them as unspecialize...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Kausch AP

    更新日期：1984-07-01 00:00:00

  • Effects of Ca2+ deficiency, collagenase, and mechanical dispersion on the ultrastructure of cardiac myocytes of adult rats.

    abstract：:A new perfusion medium for isolating cardiac myocytes from adult rats was developed, thereby yielding numerous viable cells with few morphological changes. The main factors in the isolation procedure are Ca2+ deficiency, collagenase, and mechanical dispersion. Their effects on the ultrastructure of cardiac myocytes we...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Flegler-Balon C,Behrendt H,Gerards P,Kammermeier H

    更新日期：1982-06-01 00:00:00

  • TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation.

    abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily of signaling molecules are involved in the regulation of many developmental processes that involve the interaction between mesenchymal and epithelial tissues. Smad7 is a potent inhibitor of many members of the TGF-beta family, notably TGF-beta and a...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2007.03.005

    authors： Klopcic B,Maass T,Meyer E,Lehr HA,Metzger D,Chambon P,Mann A,Blessing M

    更新日期：2007-12-01 00:00:00

  • Physiological roles of Rho and Rho effectors in mammals.

    abstract：:Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best characterized is the Rho subfamily including ubiquitously expressed RhoA and its homologs RhoB and RhoC. Upon binding GTP, Rho exerts its function...

    journal_title：European journal of cell biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejcb.2013.09.002

    authors： Thumkeo D,Watanabe S,Narumiya S

    更新日期：2013-10-01 00:00:00

  • Murine erythroleukemia (MEL) cells bear ligands for the sialoadhesin and erythroblast receptor macrophage hemagglutinins.

    abstract：:While many studies of erythropoiesis have focused on interactions between developing cells and the extracellular matrix, scant attention has been paid to the role of erythroid-macrophage interactions in this process. Murine erythroleukemia (MEL) cell lines have been used extensively in these studies to define erythroi...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Fraser IP,Gordon S

    更新日期：1994-08-01 00:00:00

  • Dipyridamole reduces the motility of 10T1/2 cells and disturbs their stress fibre pattern.

    abstract：:Dipyridamole (DPD), a widely used anti-thrombotic agent, inhibits in vitro directional migration of 10T1/2 mouse embryo cells in a dose dependent way. The inhibition is detectable at DPD concentrations comparable to those in human plasma after oral intake of the drug. Using a model for quantitative shape change analys...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Grutman G,Verschueren H

    更新日期：1984-11-01 00:00:00

  • Multicellular structures developing during maize microspore culture express endosperm and embryo-specific genes and show different embryogenic potentialities.

    abstract：:During maize pollen embryogenesis, a range of multicellular structures are formed. Using different approaches, the "nature" of these structures has been determined in terms of their embryogenic potential. In situ molecular identification techniques for gene transcripts and products, and a novel cell tracking system in...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2005.02.002

    authors： Massonneau A,Coronado MJ,Audran A,Bagniewska A,Mòl R,Testillano PS,Goralski G,Dumas C,Risueño MC,Matthys-Rochon E

    更新日期：2005-07-01 00:00:00

  • The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins.

    abstract：:Among sarcomeric muscles the cardiac muscle cells are unique by, inter alia, a systemic and extended cell-cell contact structure, the intercalated disk (ID), comprising frequent and closely spaced arrays of plaque-coated cell-cell adhering junctions (AJs). As some of these junctions may look somewhat like desmosomes a...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2005.11.003

    authors： Franke WW,Borrmann CM,Grund C,Pieperhoff S

    更新日期：2006-02-01 00:00:00

  • A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.

    abstract：:Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nu...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2011.01.003

    authors： Zhang C,Asnaghi L,Gongora C,Patek B,Hose S,Ma B,Fard MA,Brako L,Singh K,Goldberg MF,Handa JT,Lo WK,Eberhart CG,Zigler JS Jr,Sinha D

    更新日期：2011-05-01 00:00:00

  • Monitoring yeast spindles in the fluorescence microscope.

    abstract：:Formation of the complete spindles during the budding process of Saccharomyces uvarum was investigated by fluorescence microscopy of protoplasted cells. Protoplasts were treated with anti-tubulin antibodies and DAPI, a fluorescent dye staining DNA. Thus, both chromatin and spindles could be visualized. Duplication as ...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Baumstark-Khan C,Rink H,Zimmermann HP

    更新日期：1984-01-01 00:00:00

  • Terrestrial vertebrates have two keratin gene clusters; striking differences in teleost fish.

    abstract：:Keratins I and II form the largest subgroups of mammalian intermediate filament (IF) proteins and account as obligatory heteropolymers for the keratin filaments of epithelia. All human type I genes except for the K18 gene are clustered on chromosome 17q21, while all type II genes form a cluster on chromosome 12q13, th...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：10.1016/j.ejcb.2005.01.007

    authors： Zimek A,Weber K

    更新日期：2005-06-01 00:00:00

  • Electrical membrane properties of the muscle lamellae in Branchiostoma myotomes.

    abstract：:The membrane characteristics of amphioxus myotome cells were investigated using the chopped-current clamp method. The extremely thin myotome lamellae had a membrane resistance of 2.2 to 7.7 k omega cm2 and a capacity of 0.4 to 1.3 microF/micron2. The steady state current-voltage relation showed outward rectification. ...

    journal_title：European journal of cell biology

    pub_type： 杂志文章

    doi：

    authors： Melzer W

    更新日期：1982-10-01 00:00:00