A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.

Abstract:

:Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nuc1 rats migrate faster than wild type astrocytes. Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. We demonstrate that AQP4 expression is elevated in the astrocytes in PFV conditions, and we hypothesize that this causes the cells to migrate abnormally into the vitreous where they ensheath the hyaloid artery. This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system.

journal_name

Eur J Cell Biol

authors

Zhang C,Asnaghi L,Gongora C,Patek B,Hose S,Ma B,Fard MA,Brako L,Singh K,Goldberg MF,Handa JT,Lo WK,Eberhart CG,Zigler JS Jr,Sinha D

doi

10.1016/j.ejcb.2011.01.003

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

440-8

issue

5

eissn

0171-9335

issn

1618-1298

pii

S0171-9335(11)00004-5

journal_volume

90

pub_type

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