Shear stress-induced transcriptional regulation via hybrid promoters as a potential tool for promoting angiogenesis.

abstract：:Prothrombin, a protein involved in blood coagulation, is a plasma glycoprotein composed of the Gla domain, two adjacent kringle domains, and a serine protease domain. Kringles are triple-disulfide-loop folding domains, which are found in several other blood proteins. In this study, we showed that recombinant human pro...

journal_title：Angiogenesis

authors： Kim TH,Kim E,Yoon D,Kim J,Rhim TY,Kim SS

更新日期：2002-01-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：:The sprouting of endothelial cells from pre-existing blood vessels represents a critical event in the angiogenesis cascade. However, only a fraction of cultured or transplanted endothelial cells form new vessels. Moreover, it is unclear whether this results from a stochastic process or instead relates to certain endot...

journal_title：Angiogenesis

authors： Silva EA,Eseonu C,Mooney DJ

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...

journal_title：Angiogenesis

authors： Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...

journal_title：Angiogenesis

authors： Willhauck-Fleckenstein M,Moehler TM,Merling A,Pusunc S,Goldschmidt H,Schwartz-Albiez R

更新日期：2010-03-01 00:00:00

abstract：:Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...

journal_title：Angiogenesis

authors： Tang F,LeBlanc ME,Wang W,Liang D,Chen P,Chou TH,Tian H,Li W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:EPLIN (epithelial protein lost in neoplasm) is a cytoskeletal associated protein involved in the regulation of actin dynamics and subsequently in cell motility. EPLIN expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer ce...

journal_title：Angiogenesis

authors： Sanders AJ,Ye L,Mason MD,Jiang WG

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...

journal_title：Angiogenesis

authors： Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

更新日期：2018-11-01 00:00:00

abstract：:Angiopoietin-like (ANGPTL) proteins are secreted proteins showing structural similarity to members of the angiopoietin family. Some ANGPTL proteins possess pleiotropic activities, being involved in cancer lipid, glucose energy metabolisms, and angiogenesis. ANGPTL7 is the less characterized member of the family whose ...

journal_title：Angiogenesis

authors： Parri M,Pietrovito L,Grandi A,Campagnoli S,De Camilli E,Bianchini F,Marchiò S,Bussolino F,Jin B,Sarmientos P,Grandi G,Viale G,Pileri P,Chiarugi P,Grifantini R

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by interactin...

journal_title：Angiogenesis

authors： Bausch D,Pausch T,Krauss T,Hopt UT,Fernandez-del-Castillo C,Warshaw AL,Thayer SP,Keck T

更新日期：2011-09-01 00:00:00

abstract：:Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...

journal_title：Angiogenesis

authors： Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

更新日期：2013-04-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...

journal_title：Angiogenesis

authors： Ehling J,Misiewicz M,von Stillfried S,Möckel D,Bzyl J,Pochon S,Lederle W,Knuechel R,Lammers T,Palmowski M,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

journal_title：Angiogenesis

authors： Zhang Y,Wang S,Dudley AC

更新日期：2020-02-01 00:00:00

abstract：:Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

journal_title：Angiogenesis

authors： Pavlakovic H,Havers W,Schweigerer L

更新日期：2001-01-01 00:00:00

abstract：:Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...

journal_title：Angiogenesis

authors： Kalkunte S,Brard L,Granai CO,Swamy N

更新日期：2005-01-01 00:00:00

abstract：:Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data exist regarding the effects of this drug on the growth of metastases in preclinical models. Here we use 4T1 and RENCA tumour cells, which both form lung metastas...

journal_title：Angiogenesis

authors： Welti JC,Powles T,Foo S,Gourlaouen M,Preece N,Foster J,Frentzas S,Bird D,Sharpe K,van Weverwijk A,Robertson D,Soffe J,Erler JT,Pili R,Springer CJ,Mather SJ,Reynolds AR

更新日期：2012-12-01 00:00:00

abstract：:Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...

journal_title：Angiogenesis

authors： Gianni-Barrera R,Trani M,Fontanellaz C,Heberer M,Djonov V,Hlushchuk R,Banfi A

更新日期：2013-01-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...

journal_title：Angiogenesis

authors： Curatola AM,Xu J,Hendricks-Munoz KD

更新日期：2011-09-01 00:00:00

abstract：:The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...

journal_title：Angiogenesis

authors： Persigehl T,Ring J,Bremer C,Heindel W,Holtmeier R,Stypmann J,Claesener M,Hermann S,Schäfers M,Zerbst C,Schliemann C,Mesters RM,Berdel WE,Schwöppe C

更新日期：2014-01-01 00:00:00

abstract：:During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in deposition of a provision...

journal_title：Angiogenesis

authors： Vandoorne K,Addadi Y,Neeman M

更新日期：2010-06-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the development of CVDs. Piwi-interacting RNAs (piRNAs) are a novel cluster of small non-coding RNAs with strong uracil bias at the 5' end and 2'-O-met...

journal_title：Angiogenesis

authors： Li M,Yang Y,Wang Z,Zong T,Fu X,Aung LHH,Wang K,Wang JX,Yu T

更新日期：2020-10-04 00:00:00

abstract：:Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...

journal_title：Angiogenesis

authors： Costa C,Incio J,Soares R

更新日期：2007-01-01 00:00:00

abstract：:The establishment of a vascular network within tumours is a key step in the progression towards an aggressive, metastatic state, with poor prognosis. We have developed a novel in vitro model to specifically capture the interaction between endothelial cells and solid tumours. Micro-vascularised in vitro tumour construc...

journal_title：Angiogenesis

authors： Timmins NE,Dietmair S,Nielsen LK

更新日期：2004-01-01 00:00:00

abstract：:Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promisi...

journal_title：Angiogenesis

authors： Bocci M,Sjölund J,Kurzejamska E,Lindgren D,Marzouka NA,Bartoschek M,Höglund M,Pietras K

更新日期：2019-02-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：:Technology has caught up with retinal diseases of neovasculature. Work with anti-cancer, anti-angiogenic agents has fueled the way for ocular therapeutics. The market size for age-related macular degeneration and diabetic retinopathy is huge. Fifteen million people in the United States alone have age-related macular d...

journal_title：Angiogenesis

authors： Sherris D

更新日期：2007-01-01 00:00:00

abstract：:Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

journal_title：Angiogenesis

authors： Masiero L,Figg WD,Kohn EC

更新日期：1997-01-01 00:00:00

abstract：:Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...

journal_title：Angiogenesis

authors： Mukwaya A,Lennikov A,Xeroudaki M,Mirabelli P,Lachota M,Jensen L,Peebo B,Lagali N

更新日期：2018-05-01 00:00:00

abstract：:Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as...

journal_title：Angiogenesis

authors： Faughnan ME,Gossage JR,Chakinala MM,Oh SP,Kasthuri R,Hughes CCW,McWilliams JP,Parambil JG,Vozoris N,Donaldson J,Paul G,Berry P,Sprecher DL

更新日期：2019-02-01 00:00:00

abstract：:During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α parti...

journal_title：Angiogenesis

authors： Nauta TD,van den Broek M,Gibbs S,van der Pouw-Kraan TC,Oudejans CB,van Hinsbergh VW,Koolwijk P

更新日期：2017-02-01 00:00:00