Ocular drug development--future directions.

abstract：PURPOSE:There are currently no validated biomarkers predicting bevacizumab treatment outcome or toxicity. We combined biomarker data from six phase III trials of bevacizumab to assess whether genetic variation in vascular endothelial growth factor-A (VEGF-A) pathway or hypertension-related genes are associated with bev...

journal_title：Angiogenesis

authors： Lambrechts D,Moisse M,Delmar P,Miles DW,Leighl N,Escudier B,Van Cutsem E,Bansal AT,Carmeliet P,Scherer SJ,de Haas S,Pallaud C

更新日期：2014-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...

journal_title：Angiogenesis

authors： Miwa D,Sakaue T,Inoue H,Takemori N,Kurokawa M,Fukuda S,Omi K,Goishi K,Higashiyama S

更新日期：2013-07-01 00:00:00

abstract：:Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...

journal_title：Angiogenesis

authors： Kalkunte S,Brard L,Granai CO,Swamy N

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs) to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes lead to the inherited vascular disorder hereditary haemorrhagic telangiectasia (HHT), characterised by arteriovenous malformations (AVMs). Howev...

journal_title：Angiogenesis

authors： Singh E,Redgrave RE,Phillips HM,Arthur HM

更新日期：2020-11-01 00:00:00

abstract：:The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...

journal_title：Angiogenesis

authors： Liang H,Ge F,Xu Y,Xiao J,Zhou Z,Liu R,Chen C

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Angiogenesis plays a pivotal role in neoplastic growth and metastasis formation. Vascular endothelial growth factor A (VEGFA) is a major player in physiological and tumour-induced angiogenesis and numerous human tumours have been show to overexpress VEGFA. Moreover increased VEGFA gene expression has been fo...

journal_title：Angiogenesis

authors： Andreozzi M,Quagliata L,Gsponer JR,Ruiz C,Vuaroqueaux V,Eppenberger-Castori S,Tornillo L,Terracciano LM

更新日期：2014-07-01 00:00:00

abstract：:Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...

journal_title：Angiogenesis

authors： Lanza GM,Winter PM,Caruthers SD,Hughes MS,Hu G,Schmieder AH,Wickline SA

更新日期：2010-06-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the development of CVDs. Piwi-interacting RNAs (piRNAs) are a novel cluster of small non-coding RNAs with strong uracil bias at the 5' end and 2'-O-met...

journal_title：Angiogenesis

authors： Li M,Yang Y,Wang Z,Zong T,Fu X,Aung LHH,Wang K,Wang JX,Yu T

更新日期：2020-10-04 00:00:00

abstract：:Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow fo...

journal_title：Angiogenesis

authors： Cuervo H,Pereira B,Nadeem T,Lin M,Lee F,Kitajewski J,Lin CS

更新日期：2017-11-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...

journal_title：Angiogenesis

authors： Afonyushkin T,Oskolkova OV,Bochkov VN

更新日期：2018-05-01 00:00:00

abstract：:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimula...

journal_title：Angiogenesis

authors： Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:In patients with resectable colorectal liver metastases (CRLM), distinct histopathological growth patterns (HGPs) develop at the interface between the tumour and surrounding tissue. The desmoplastic (d) HGP is characterised by angiogenesis and a peripheral fibrotic rim, whereas non-angiogenic HGPs co-opt end...

journal_title：Angiogenesis

authors： Galjart B,Nierop PMH,van der Stok EP,van den Braak RRJC,Höppener DJ,Daelemans S,Dirix LY,Verhoef C,Vermeulen PB,Grünhagen DJ

更新日期：2019-05-01 00:00:00

abstract：:Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...

journal_title：Angiogenesis

authors： Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...

journal_title：Angiogenesis

authors： Goss JA,Konczyk DJ,Smits PJ,Kozakewich HPW,Alomari AI,Al-Ibraheemi A,Taghinia AH,Dickie BH,Adams DM,Fishman SJ,Mulliken JB,Warman ML,Greene AK

更新日期：2019-11-01 00:00:00

abstract：:Angiogenesis, or new blood vessel formation, is an important process in the pathogenesis of several diseases and thus has been targeted for the prevention and treatment for many disorders. However, the anti-angiogenic agents that are currently in use are mainly synthetic compounds and humanized monoclonal antibodies, ...

journal_title：Angiogenesis

authors： Lu K,Bhat M,Basu S

更新日期：2016-07-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR...

journal_title：Angiogenesis

authors： Ma T,Patel H,Babapoor-Farrokhran S,Franklin R,Semenza GL,Sodhi A,Montaner S

更新日期：2015-10-01 00:00:00

abstract：:The sprouting of endothelial cells from pre-existing blood vessels represents a critical event in the angiogenesis cascade. However, only a fraction of cultured or transplanted endothelial cells form new vessels. Moreover, it is unclear whether this results from a stochastic process or instead relates to certain endot...

journal_title：Angiogenesis

authors： Silva EA,Eseonu C,Mooney DJ

更新日期：2014-07-01 00:00:00

abstract：:Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...

journal_title：Angiogenesis

authors： Mukwaya A,Lennikov A,Xeroudaki M,Mirabelli P,Lachota M,Jensen L,Peebo B,Lagali N

更新日期：2018-05-01 00:00:00

abstract：:Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...

journal_title：Angiogenesis

authors： Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

更新日期：2013-04-01 00:00:00

abstract：:Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data exist regarding the effects of this drug on the growth of metastases in preclinical models. Here we use 4T1 and RENCA tumour cells, which both form lung metastas...

journal_title：Angiogenesis

authors： Welti JC,Powles T,Foo S,Gourlaouen M,Preece N,Foster J,Frentzas S,Bird D,Sharpe K,van Weverwijk A,Robertson D,Soffe J,Erler JT,Pili R,Springer CJ,Mather SJ,Reynolds AR

更新日期：2012-12-01 00:00:00

abstract：:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

journal_title：Angiogenesis

authors： Zhang Y,Wang S,Dudley AC

更新日期：2020-02-01 00:00:00

abstract：:Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...

journal_title：Angiogenesis

authors： Tang F,LeBlanc ME,Wang W,Liang D,Chen P,Chou TH,Tian H,Li W

更新日期：2019-08-01 00:00:00

abstract：:Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...

journal_title：Angiogenesis

authors： Knowles LM,Malik G,Hood BL,Conrads TP,Pilch J

更新日期：2012-03-01 00:00:00

abstract：:Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...

journal_title：Angiogenesis

authors： Costa C,Incio J,Soares R

更新日期：2007-01-01 00:00:00

abstract：:Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we ...

journal_title：Angiogenesis

authors： Fujita M,Ikemoto M,Tanaka T,Tamaki S,Yamazato A,Sawamura T,Hasegawa K,Kihara Y,Nohara R,Sasayama S

更新日期：1998-01-01 00:00:00

abstract：:Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...

journal_title：Angiogenesis

authors： Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

更新日期：2018-05-01 00:00:00

abstract：:A missense mutation from arginine to tryptophan at residue 849 in the kinase domain of Tie2 (Tie2-R849W) is commonly identified in familial venous malformations. The mechanistic action of Tie2-R849W variant expression on angiogenic cascades including smooth muscle cell recruitment, however, remains elusive. To avoid c...

journal_title：Angiogenesis

authors： Huang YH,Wu MP,Pan SC,Su WC,Chen YW,Wu LW

更新日期：2013-01-01 00:00:00

abstract：:When human umbilical vein endothelial cells (HUVEC) differentiate into capillary-like tubes, there is a five-fold upregulation of the mRNA for thymosin beta4 (Tbeta4) (Grant et al. J Cell Sci 1995; 108: 3685-94 [1]) and this endogenous expression plays an important role in endothelial cell attachment to and spreading ...

journal_title：Angiogenesis

authors： Grant DS,Rose W,Yaen C,Goldstein A,Martinez J,Kleinman H

更新日期：1999-01-01 00:00:00

abstract：:The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...

journal_title：Angiogenesis

authors： Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

更新日期：2008-01-01 00:00:00