Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.

abstract：:Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...

journal_title：Angiogenesis

authors： Curatola AM,Xu J,Hendricks-Munoz KD

更新日期：2011-09-01 00:00:00

abstract：:Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...

journal_title：Angiogenesis

authors： Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

更新日期：1999-01-01 00:00:00

abstract：:Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...

journal_title：Angiogenesis

authors： Lin CI,Merley A,Sciuto TE,Li D,Dvorak AM,Melero-Martin JM,Dvorak HF,Jaminet SC

更新日期：2014-10-01 00:00:00

abstract：:noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Noni in concentr...

journal_title：Angiogenesis

authors： Hornick CA,Myers A,Sadowska-Krowicka H,Anthony CT,Woltering EA

更新日期：2003-01-01 00:00:00

abstract：:The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...

journal_title：Angiogenesis

authors： Liang H,Ge F,Xu Y,Xiao J,Zhou Z,Liu R,Chen C

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...

journal_title：Angiogenesis

authors： Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

更新日期：2016-04-01 00:00:00

abstract：:Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...

journal_title：Angiogenesis

authors： Sunamura M,Duda DG,Ghattas MH,Lozonschi L,Motoi F,Yamauchi J,Matsuno S,Shibahara S,Abraham NG

更新日期：2003-01-01 00:00:00

abstract：:Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...

journal_title：Angiogenesis

authors： van Wijk XM,van Kuppevelt TH

更新日期：2014-07-01 00:00:00

abstract：:Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...

journal_title：Angiogenesis

authors： Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

更新日期：2017-05-01 00:00:00

abstract：:The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...

journal_title：Angiogenesis

authors： Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

更新日期：2003-01-01 00:00:00

abstract：:Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...

journal_title：Angiogenesis

authors： Lanza GM,Winter PM,Caruthers SD,Hughes MS,Hu G,Schmieder AH,Wickline SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...

journal_title：Angiogenesis

authors： Goss JA,Konczyk DJ,Smits PJ,Kozakewich HPW,Alomari AI,Al-Ibraheemi A,Taghinia AH,Dickie BH,Adams DM,Fishman SJ,Mulliken JB,Warman ML,Greene AK

更新日期：2019-11-01 00:00:00

abstract：:Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid...

journal_title：Angiogenesis

authors： Le Cras TD,Mobberley-Schuman PS,Broering M,Fei L,Trenor CC 3rd,Adams DM

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...

journal_title：Angiogenesis

authors： Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

更新日期：2018-11-01 00:00:00

abstract：:The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...

journal_title：Angiogenesis

authors： Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

更新日期：2008-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic destructive musculo-skeletal disorder, associated with thickening of the synovial membrane lining the joints, inflammation and hyperproliferation of synovial cells, as well as a pro-inflammatory cytokine cascade, leukocyte infiltration, and tissue damage and bone resorption. An e...

journal_title：Angiogenesis

authors： Paleolog EM,Miotla JM

更新日期：1998-01-01 00:00:00

abstract：:Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether ...

journal_title：Angiogenesis

authors： Zhou J,Zhang H,Wang H,Lutz AM,El Kaffas A,Tian L,Hristov D,Willmann JK

更新日期：2017-11-01 00:00:00

abstract：:Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...

journal_title：Angiogenesis

authors： Weigand M,Hantel P,Kreienberg R,Waltenberger J

更新日期：2005-01-01 00:00:00

abstract：:Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...

journal_title：Angiogenesis

authors： Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

更新日期：2013-04-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...

journal_title：Angiogenesis

authors： Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

更新日期：2020-05-01 00:00:00

abstract：:During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...

journal_title：Angiogenesis

authors： Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld M

更新日期：2012-06-01 00:00:00

abstract：:Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...

journal_title：Angiogenesis

authors： Mukwaya A,Lennikov A,Xeroudaki M,Mirabelli P,Lachota M,Jensen L,Peebo B,Lagali N

更新日期：2018-05-01 00:00:00

abstract：:The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....

journal_title：Angiogenesis

authors： Li Q,Michaud M,Canosa S,Kuo A,Madri JA

更新日期：2011-05-01 00:00:00

abstract：:The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...

journal_title：Angiogenesis

authors： Nowak-Sliwinska P,Segura T,Iruela-Arispe ML

更新日期：2014-10-01 00:00:00

abstract：:Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

journal_title：Angiogenesis

authors： Pavlakovic H,Havers W,Schweigerer L

更新日期：2001-01-01 00:00:00

abstract：:Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...

journal_title：Angiogenesis

authors： Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

更新日期：2018-05-01 00:00:00

abstract：:Angiopoietin-like (ANGPTL) proteins are secreted proteins showing structural similarity to members of the angiopoietin family. Some ANGPTL proteins possess pleiotropic activities, being involved in cancer lipid, glucose energy metabolisms, and angiogenesis. ANGPTL7 is the less characterized member of the family whose ...

journal_title：Angiogenesis

authors： Parri M,Pietrovito L,Grandi A,Campagnoli S,De Camilli E,Bianchini F,Marchiò S,Bussolino F,Jin B,Sarmientos P,Grandi G,Viale G,Pileri P,Chiarugi P,Grifantini R

更新日期：2014-10-01 00:00:00

abstract：:Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...

journal_title：Angiogenesis

authors： Denbeigh JM,Nixon BA,Lee JJ,Jerkic M,Marsden PA,Letarte M,Puri MC,Foster FS

更新日期：2015-01-01 00:00:00

abstract：:Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is h...

journal_title：Angiogenesis

authors： Alghanem AF,Wilkinson EL,Emmett MS,Aljasir MA,Holmes K,Rothermel BA,Simms VA,Heath VL,Cross MJ

更新日期：2017-08-01 00:00:00