Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.


:Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we measured the concentrations of VEGF and bFGF in pericardial fluid of 51 patients with open heart surgery. Patients were divided into group A (n=10) with class III unstable angina (Braunwald's classification), group B (n=24) with class I or II unstable angina or stable angina and group C (n=17) with non-ischemic heart disease. The VEGF level in pericardial fluid in group A was 83+/-7 pg/ml, being significantly (p<0.001) higher than the 27+/-3 pg/ml in group B and the 28+/-5 pg/ml in group C. The concentrations of bFGF in pericardial fluid in groups A and B were 1461+/-579 and 1224+/-161 pg/ml, respectively, significantly (p<0.05) higher than the 292+/-97 pg/ml in group C. The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease. Thus VEGF and bFGF may play important roles in mediating collateral growth in humans.






Fujita M,Ikemoto M,Tanaka T,Tamaki S,Yamazato A,Sawamura T,Hasegawa K,Kihara Y,Nohara R,Sasayama S




Has Abstract


1998-01-01 00:00:00














  • Cyclic GMP protects endothelial progenitors from oxidative stress.

    abstract::Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...


    pub_type: 杂志文章


    authors: Curatola AM,Xu J,Hendricks-Munoz KD

    更新日期:2011-09-01 00:00:00

  • Transcriptional profiling of human microvascular endothelial cells in the proliferative and quiescent state using cDNA arrays.

    abstract::Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...


    pub_type: 杂志文章


    authors: Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

    更新日期:1999-01-01 00:00:00

  • TM4SF1: a new vascular therapeutic target in cancer.

    abstract::Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...


    pub_type: 杂志文章


    authors: Lin CI,Merley A,Sciuto TE,Li D,Dvorak AM,Melero-Martin JM,Dvorak HF,Jaminet SC

    更新日期:2014-10-01 00:00:00

  • Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni).

    abstract::noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Noni in concentr...


    pub_type: 杂志文章


    authors: Hornick CA,Myers A,Sadowska-Krowicka H,Anthony CT,Woltering EA

    更新日期:2003-01-01 00:00:00

  • miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells.

    abstract::The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...


    pub_type: 杂志文章


    authors: Liang H,Ge F,Xu Y,Xiao J,Zhou Z,Liu R,Chen C

    更新日期:2018-11-01 00:00:00

  • Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis.

    abstract:BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...


    pub_type: 杂志文章,meta分析


    authors: Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

    更新日期:2016-04-01 00:00:00

  • Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.

    abstract::Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...


    pub_type: 杂志文章


    authors: Sunamura M,Duda DG,Ghattas MH,Lozonschi L,Motoi F,Yamauchi J,Matsuno S,Shibahara S,Abraham NG

    更新日期:2003-01-01 00:00:00

  • Heparan sulfate in angiogenesis: a target for therapy.

    abstract::Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...


    pub_type: 杂志文章,评审


    authors: van Wijk XM,van Kuppevelt TH

    更新日期:2014-07-01 00:00:00

  • The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future.

    abstract::Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...


    pub_type: 历史文章,杂志文章,评审


    authors: Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

    更新日期:2017-05-01 00:00:00

  • The role of the fibrinolytic system in corneal angiogenesis.

    abstract::The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...


    pub_type: 杂志文章


    authors: Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

    更新日期:2003-01-01 00:00:00

  • Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions.

    abstract::Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...


    pub_type: 杂志文章,评审


    authors: Lanza GM,Winter PM,Caruthers SD,Hughes MS,Hu G,Schmieder AH,Wickline SA

    更新日期:2010-06-01 00:00:00

  • Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations.

    abstract:BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...


    pub_type: 杂志文章


    authors: Goss JA,Konczyk DJ,Smits PJ,Kozakewich HPW,Alomari AI,Al-Ibraheemi A,Taghinia AH,Dickie BH,Adams DM,Fishman SJ,Mulliken JB,Warman ML,Greene AK

    更新日期:2019-11-01 00:00:00

  • Angiopoietins as serum biomarkers for lymphatic anomalies.

    abstract::Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid...


    pub_type: 杂志文章


    authors: Le Cras TD,Mobberley-Schuman PS,Broering M,Fei L,Trenor CC 3rd,Adams DM

    更新日期:2017-02-01 00:00:00

  • EphB4 mediates resistance to antiangiogenic therapy in experimental glioma.

    abstract:INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...


    pub_type: 杂志文章


    authors: Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

    更新日期:2018-11-01 00:00:00

  • Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation.

    abstract::The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...


    pub_type: 杂志文章


    authors: Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

    更新日期:2008-01-01 00:00:00

  • Angiogenesis in arthritis: role in disease pathogenesis and as a potential therapeutic target.

    abstract::Rheumatoid arthritis (RA) is a chronic destructive musculo-skeletal disorder, associated with thickening of the synovial membrane lining the joints, inflammation and hyperproliferation of synovial cells, as well as a pro-inflammatory cytokine cascade, leukocyte infiltration, and tissue damage and bone resorption. An e...


    pub_type: 杂志文章


    authors: Paleolog EM,Miotla JM

    更新日期:1998-01-01 00:00:00

  • Early prediction of tumor response to bevacizumab treatment in murine colon cancer models using three-dimensional dynamic contrast-enhanced ultrasound imaging.

    abstract::Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether ...


    pub_type: 杂志文章


    authors: Zhou J,Zhang H,Wang H,Lutz AM,El Kaffas A,Tian L,Hristov D,Willmann JK

    更新日期:2017-11-01 00:00:00

  • Autocrine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro.

    abstract::Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...


    pub_type: 杂志文章


    authors: Weigand M,Hantel P,Kreienberg R,Waltenberger J

    更新日期:2005-01-01 00:00:00

  • Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.

    abstract::Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...


    pub_type: 杂志文章


    authors: Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

    更新日期:2013-04-01 00:00:00

  • Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development.

    abstract::In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...


    pub_type: 杂志文章


    authors: Metikala S,Neuhaus H,Hollemann T

    更新日期:2016-04-01 00:00:00

  • Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation.

    abstract:INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...


    pub_type: 杂志文章


    authors: Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

    更新日期:2020-05-01 00:00:00

  • DNA methylation regulates lineage-specifying genes in primary lymphatic and blood endothelial cells.

    abstract::During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...


    pub_type: 临床试验,杂志文章


    authors: Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld M

    更新日期:2012-06-01 00:00:00

  • Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization.

    abstract::Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...


    pub_type: 杂志文章


    authors: Mukwaya A,Lennikov A,Xeroudaki M,Mirabelli P,Lachota M,Jensen L,Peebo B,Lagali N

    更新日期:2018-05-01 00:00:00

  • GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.

    abstract::The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....


    pub_type: 杂志文章


    authors: Li Q,Michaud M,Canosa S,Kuo A,Madri JA

    更新日期:2011-05-01 00:00:00

  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering.

    abstract::The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...


    pub_type: 杂志文章,评审


    authors: Nowak-Sliwinska P,Segura T,Iruela-Arispe ML

    更新日期:2014-10-01 00:00:00

  • Multiple angiogenesis stimulators in a single malignancy: implications for anti-angiogenic tumour therapy.

    abstract::Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...


    pub_type: 杂志文章


    authors: Pavlakovic H,Havers W,Schweigerer L

    更新日期:2001-01-01 00:00:00

  • Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system.

    abstract::Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...


    pub_type: 杂志文章


    authors: Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

    更新日期:2018-05-01 00:00:00

  • Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer.

    abstract::Angiopoietin-like (ANGPTL) proteins are secreted proteins showing structural similarity to members of the angiopoietin family. Some ANGPTL proteins possess pleiotropic activities, being involved in cancer lipid, glucose energy metabolisms, and angiogenesis. ANGPTL7 is the less characterized member of the family whose ...


    pub_type: 杂志文章


    authors: Parri M,Pietrovito L,Grandi A,Campagnoli S,De Camilli E,Bianchini F,Marchiò S,Bussolino F,Jin B,Sarmientos P,Grandi G,Viale G,Pileri P,Chiarugi P,Grifantini R

    更新日期:2014-10-01 00:00:00

  • Contrast-enhanced molecular ultrasound differentiates endoglin genotypes in mouse embryos.

    abstract::Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...


    pub_type: 杂志文章


    authors: Denbeigh JM,Nixon BA,Lee JJ,Jerkic M,Marsden PA,Letarte M,Puri MC,Foster FS

    更新日期:2015-01-01 00:00:00

  • RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.

    abstract::Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is h...


    pub_type: 杂志文章


    authors: Alghanem AF,Wilkinson EL,Emmett MS,Aljasir MA,Holmes K,Rothermel BA,Simms VA,Heath VL,Cross MJ

    更新日期:2017-08-01 00:00:00