Visualizing vascular permeability and lymphatic drainage using labeled serum albumin.

Abstract:

:During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in deposition of a provisional matrix, elevation of the interstitial pressure and induction of interstitial convection. Albumin, the major plasma protein appears to be an innocent bystander that is significantly affected by these changes, and thus can be used as a biomarker for vascular permeability associated with angiogenesis. Traditionally, albumin leak in superficial organs was followed by colorimetry or morphometry with the use of albumin binding vital dyes. Over the last years, the introduction of tagged-albumin that can be detected by various imaging methods, such as magnetic resonance imaging and positron emission tomography, opened new possibilities for quantitative three dimension dynamic analysis of permeability in any organ. Using these tools it is now possible to follow not only vascular permeability, but also interstitial convection and lymphatic drain. Active uptake of tagged albumin by caveolae-mediated endocytosis opens the possibility for using labeled albumin for vital staining of cells and cell tracking. This approach was used for monitoring recruitment of perivascular stroma fibroblasts associated with tumor angiogenesis.

journal_name

Angiogenesis

journal_title

Angiogenesis

authors

Vandoorne K,Addadi Y,Neeman M

doi

10.1007/s10456-010-9170-4

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

75-85

issue

2

eissn

0969-6970

issn

1573-7209

journal_volume

13

pub_type

杂志文章,评审
  • Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system.

    abstract::Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-018-9601-1

    authors: Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

    更新日期:2018-05-01 00:00:00

  • New anti-angiogenesis agents: review of the clinical experience with carboxyamido-triazole (CAI), thalidomide, TNP-470 and interleukin-12.

    abstract::Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/A:1018301031580

    authors: Masiero L,Figg WD,Kohn EC

    更新日期:1997-01-01 00:00:00

  • EphB4 mediates resistance to antiangiogenic therapy in experimental glioma.

    abstract:INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-018-9633-6

    authors: Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

    更新日期:2018-11-01 00:00:00

  • TM4SF1: a new vascular therapeutic target in cancer.

    abstract::Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-014-9437-2

    authors: Lin CI,Merley A,Sciuto TE,Li D,Dvorak AM,Melero-Martin JM,Dvorak HF,Jaminet SC

    更新日期:2014-10-01 00:00:00

  • Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer.

    abstract::Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vasculari...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-015-9474-5

    authors: Mao G,Liu Y,Fang X,Liu Y,Fang L,Lin L,Liu X,Wang N

    更新日期:2015-07-01 00:00:00

  • Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.

    abstract::Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-017-9590-5

    authors: Afonyushkin T,Oskolkova OV,Bochkov VN

    更新日期:2018-05-01 00:00:00

  • Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models.

    abstract::Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-013-9357-6

    authors: Zhu XD,Sun HC,Xu HX,Kong LQ,Chai ZT,Lu L,Zhang JB,Gao DM,Wang WQ,Zhang W,Zhuang PY,Wu WZ,Wang L,Tang ZY

    更新日期:2013-10-01 00:00:00

  • Thymosin beta4 enhances endothelial cell differentiation and angiogenesis.

    abstract::When human umbilical vein endothelial cells (HUVEC) differentiate into capillary-like tubes, there is a five-fold upregulation of the mRNA for thymosin beta4 (Tbeta4) (Grant et al. J Cell Sci 1995; 108: 3685-94 [1]) and this endogenous expression plays an important role in endothelial cell attachment to and spreading ...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/a:1009041911493

    authors: Grant DS,Rose W,Yaen C,Goldstein A,Martinez J,Kleinman H

    更新日期:1999-01-01 00:00:00

  • CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.

    abstract::Vascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a re...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-018-9638-1

    authors: Chrifi I,Louzao-Martinez L,Brandt MM,van Dijk CGM,Bürgisser PE,Zhu C,Kros JM,Verhaar MC,Duncker DJ,Cheng C

    更新日期:2019-02-01 00:00:00

  • The role of the fibrinolytic system in corneal angiogenesis.

    abstract::The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/B:AGEN.0000029414.24060.fe

    authors: Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

    更新日期:2003-01-01 00:00:00

  • PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis.

    abstract::Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow fo...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-017-9570-9

    authors: Cuervo H,Pereira B,Nadeem T,Lin M,Lee F,Kitajewski J,Lin CS

    更新日期:2017-11-01 00:00:00

  • Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia.

    abstract::Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as...

    journal_title:Angiogenesis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s10456-018-9646-1

    authors: Faughnan ME,Gossage JR,Chakinala MM,Oh SP,Kasthuri R,Hughes CCW,McWilliams JP,Parambil JG,Vozoris N,Donaldson J,Paul G,Berry P,Sprecher DL

    更新日期:2019-02-01 00:00:00

  • The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future.

    abstract::Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...

    journal_title:Angiogenesis

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s10456-017-9546-9

    authors: Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

    更新日期:2017-05-01 00:00:00

  • Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis.

    abstract:BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...

    journal_title:Angiogenesis

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10456-016-9500-2

    authors: Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

    更新日期:2016-04-01 00:00:00

  • Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells.

    abstract::Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-015-9484-3

    authors: Yao J,Guihard PJ,Blazquez-Medela AM,Guo Y,Liu T,Boström KI,Yao Y

    更新日期:2016-01-01 00:00:00

  • Models and molecular mechanisms of blood vessel co-option by cancer cells.

    abstract::Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-019-09684-y

    authors: Zhang Y,Wang S,Dudley AC

    更新日期:2020-02-01 00:00:00

  • Vascular development in endometriosis.

    abstract::Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-005-9005-x

    authors: Groothuis PG,Nap AW,Winterhager E,Grümmer R

    更新日期:2005-01-01 00:00:00

  • To be or not to be: endothelial cell plasticity in development, repair, and disease.

    abstract::Endothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and ot...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-020-09761-7

    authors: Greenspan LJ,Weinstein BM

    更新日期:2021-01-15 00:00:00

  • CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism.

    abstract::CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/a:1016752925761

    authors: Nanney LB,Wamil BD,Whitsitt J,Cardwell NL,Davidson JM,Yan HP,Hellerqvist CG

    更新日期:2001-01-01 00:00:00

  • Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by interactin...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-011-9207-3

    authors: Bausch D,Pausch T,Krauss T,Hopt UT,Fernandez-del-Castillo C,Warshaw AL,Thayer SP,Keck T

    更新日期:2011-09-01 00:00:00

  • Autocrine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro.

    abstract::Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-005-9010-0

    authors: Weigand M,Hantel P,Kreienberg R,Waltenberger J

    更新日期:2005-01-01 00:00:00

  • Plants and their active compounds: natural molecules to target angiogenesis.

    abstract::Angiogenesis, or new blood vessel formation, is an important process in the pathogenesis of several diseases and thus has been targeted for the prevention and treatment for many disorders. However, the anti-angiogenic agents that are currently in use are mainly synthetic compounds and humanized monoclonal antibodies, ...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-016-9512-y

    authors: Lu K,Bhat M,Basu S

    更新日期:2016-07-01 00:00:00

  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering.

    abstract::The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-014-9440-7

    authors: Nowak-Sliwinska P,Segura T,Iruela-Arispe ML

    更新日期:2014-10-01 00:00:00

  • Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions.

    abstract::Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-010-9166-0

    authors: Lanza GM,Winter PM,Caruthers SD,Hughes MS,Hu G,Schmieder AH,Wickline SA

    更新日期:2010-06-01 00:00:00

  • TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.

    abstract::Transmembrane-4-L-six-family-1 (TM4SF1) is a tetraspanin-like membrane protein that is highly and selectively expressed by cultured endothelial cells (EC) and, in vivo, by EC lining angiogenic tumor blood vessels. TM4SF1 is necessary for the formation of unusually long (up to a 50 μm), thin (~100-300 nm wide), F-actin...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-011-9218-0

    authors: Zukauskas A,Merley A,Li D,Ang LH,Sciuto TE,Salman S,Dvorak AM,Dvorak HF,Jaminet SC

    更新日期:2011-09-01 00:00:00

  • Multiple angiogenesis stimulators in a single malignancy: implications for anti-angiogenic tumour therapy.

    abstract::Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/a:1016045012466

    authors: Pavlakovic H,Havers W,Schweigerer L

    更新日期:2001-01-01 00:00:00

  • CLT1 targets angiogenic endothelium through CLIC1 and fibronectin.

    abstract::Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-011-9247-8

    authors: Knowles LM,Malik G,Hood BL,Conrads TP,Pilch J

    更新日期:2012-03-01 00:00:00

  • Antiangiogenic tyrosine kinase inhibition related gastrointestinal perforations: a case report and literature review.

    abstract::Anti-VEGF (vascular endothelial growth factor) therapy with the monoclonal antibody bevacizumab can cause gastrointestinal (GI) perforations. In recent years it became apparent that GI perforations also occur during treatment with antiangiogenic tyrosine kinase inhibitors (TKIs). It is of clinical importance to consid...

    journal_title:Angiogenesis

    pub_type: 杂志文章,评审

    doi:10.1007/s10456-010-9197-6

    authors: Walraven M,Witteveen PO,Lolkema MP,van Hillegersberg R,Voest EE,Verheul HM

    更新日期:2011-05-01 00:00:00

  • CXCR4(+) dendritic cells promote angiogenesis during embryo implantation in mice.

    abstract::Early pregnancy is characterized by decidual adaption to the developing embryo involving angiogenesis and vascular growth. Failure of decidual vascular expansion is linked to diseases of pregnancy. Dendritic cells (DC) have been associated with vascular growth during early gestation, though it is unknown whether their...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1007/s10456-012-9325-6

    authors: Barrientos G,Tirado-González I,Freitag N,Kobelt P,Moschansky P,Klapp BF,Thijssen VL,Blois SM

    更新日期:2013-04-01 00:00:00

  • Recombinant human prothrombin kringles have potent anti-angiogenic activities and inhibit Lewis lung carcinoma tumor growth and metastases.

    abstract::Prothrombin, a protein involved in blood coagulation, is a plasma glycoprotein composed of the Gla domain, two adjacent kringle domains, and a serine protease domain. Kringles are triple-disulfide-loop folding domains, which are found in several other blood proteins. In this study, we showed that recombinant human pro...

    journal_title:Angiogenesis

    pub_type: 杂志文章

    doi:10.1023/a:1023835102832

    authors: Kim TH,Kim E,Yoon D,Kim J,Rhim TY,Kim SS

    更新日期:2002-01-01 00:00:00