Abstract：
:We present an autopsy case of a 29-week-old male fetus with a very unusual set of congenital granular cell tumors, including gingival epulis and granular cell lesions of the kidneys, lung, heart, esophagus, small and large intestine, thyroid, adrenals, spleen, urinary bladder, testis, pituitary, and leptomeninges. The granular cells were distributed mainly through the stroma of the organs, but they also involved the epithelial lining of the seminiferous and renal tubules. Ultrastructurally, the gingival, pulmonary, and renal tumors were basically the same in appearance as membrane-bound heterogeneous bodies. Immunohistochemical studies were negative for S100 protein, lysozyme, alpha 1-antitrypsin, cytokeratin, and vimentin in the gingival mass as well as in other systemic lesions. The immunohistochemical reaction pattern of the granular cells in our case was more like the cells of the congenital granular cell epulis rather than adult granular cell tumor because of its negative reaction to S100 protein. However, the involvement pattern was that of the adult form of granular cell tumor. Several developmentally different cells, such as renal tubular epithelial cells, seminiferous tubular cells, gingival stromal cells, and parenchymal cells of many organs, were involved in this granular cell process. The myofibroblastlike cells seen in the region of segmental dysplasia of the kidney showed the same cytoplasmic material as in typical granular cells. Based on these findings, it is suggested that a histogenesis of multiple cell origin of the granular cell tumor could be strongly supported.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Park SH,Kim TJ,Chi JGsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
934-8issue
9eissn
0003-9985issn
1543-2165journal_volume
115pub_type
杂志文章,评审abstract：:We describe unique features seen in a case of classic acoustic schwannoma. In the central portion of the tumor, abundant Rosenthal fibers and occasional eosinophilic granular bodies were present. Rosenthal fibers are homogeneous eosinophilic structures commonly seen in central nervous system lesions, such as pilocytic...
journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
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更新日期：1987-11-01 00:00:00
abstract：:Whipple disease is a chronic, relapsing, and multisystem disease. It presents a diagnostic challenge for both clinicians and pathologists. Recent advances in isolation and culture have identified the organism responsible for the disease to be a member of the order Actinomycetes designated Tropheryma whipplei. Several ...
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abstract：CONTEXT:Although the early post-myelosuppressive chemotherapy pathologic changes of the marrow have been described, the rate and the histologic definition of recovery are not defined. OBJECTIVE:To study the rate of recovery of bone marrow in patients given myelosuppressive therapy for acute myelogenous leukemia, estab...
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更新日期：1983-09-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
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更新日期：1998-02-01 00:00:00
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更新日期：1984-02-01 00:00:00
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更新日期：1996-01-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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更新日期：1990-04-01 00:00:00
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更新日期：1994-10-01 00:00:00
