Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms.

Abstract:

:Accurate assessment of tissues for hematolymphoid neoplasms requires an integrated multiparameter approach. Although morphologic examination by light microscopy remains the mainstay of initial assessment for hematolymphoid neoplasms, immunophenotypic analysis by immunohistochemistry and/or flow cytometry is essential to determine the pattern of differentiation and to detect minimal disease when morphology is inconclusive. In some cases, immunophenotypic analysis provides additional information for targeted immunotherapy and prognostication. Genotypic studies, including cytogenetics, fluorescence in situ hybridization, DNA microarray, polymerase chain reaction, and/or next-generation sequencing, are also imperative for subclassification of the genetically defined disease entities in the current World Health Organization classification of hematolymphoid neoplasms. Moreover, genotypic studies can establish clonality, stratify patients to determine appropriate treatment, and monitor patients for treatment response.

journal_name

Arch Pathol Lab Med

authors

Li S,Jaye DL,Bradley KT,Zhang L,Saxe D,Deeb G,Hill CE,Mann KP

doi

10.5858/arpa.2016-0260-SA

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

341-354

issue

3

eissn

0003-9985

issn

1543-2165

journal_volume

141

pub_type

杂志文章,评审
  • Papillary adenoma of the stomach. Pathologic and immunohistochemical study.

    abstract::A total of 13 gastric papillary adenomas composed of 8 papillary and 5 papillotubular adenomas were examined pathologically and immunohistochemically. They showed a dome-like or pedunculated appearance and were located at the antrum, except for one adenoma. Histologically, the adenoma cells showed atypia in varying de...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Ito H,Yokozaki H,Ito M,Tahara E

    更新日期:1989-09-01 00:00:00

  • Survey of serum enzyme analyses. Human tissues as a source of enzymes.

    abstract::The College of American Pathologists' enzyme survey permits the evaluation of the quality of enzyme analyses in clinical laboratories. Animal source enzymes for lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and creatine kinase are satisfactory as supplements for enzyme survey serum, sinc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Lott JA,Tholen DW,Massion CG

    更新日期:1984-12-01 00:00:00

  • Identification of dense deposit disease: a report for the International Study of Kidney Diseases in Children.

    abstract::The fluorescent dye thioflavin T stains intensely the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavin T staining with electron microscopy was carried out in 25 patients and showed excellent congruity. Thioflavin T is much easier to use, but is less specific than ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Churg J,Duffy JL,Bernstein J

    更新日期:1979-02-01 00:00:00

  • Cytogenetics and cancer.

    abstract::When present, chromosome abnormalities can contribute useful information for tumor diagnosis and prognosis. However, the existence of diploid tumor cells indicates that such abnormalities are not necessary in tumors. Their time of appearance, sometimes preceding or predisposing to tumor and sometimes occurring late in...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Wolman SR

    更新日期:1984-01-01 00:00:00

  • Quantification of errors in laboratory reports. A quality improvement study of the College of American Pathologists' Q-Probes program.

    abstract::Over a 3-month period, 61,496 errors were detected in clinical laboratory reports by 631 participants in the College of American Pathologists' 1990 Q-Probes program. Each error detected was defined as an opportunity for improvement. Almost 4% of the detected errors were attributed to nonlaboratory personnel and approx...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Howanitz PJ,Walker K,Bachner P

    更新日期:1992-07-01 00:00:00

  • Drug-specific Fab therapy in drug overdose.

    abstract::The use of digoxin-specific fragments, antigen-binding (Fab) for antidotal therapy of severe digitalis intoxication is rapidly becoming a treatment of choice. Furthermore, studies with this mode of drug-specific therapy using Fab specific for desipramine and for phencyclidine suggest that this treatment may be applica...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hursting MJ,Raisys VA,Opheim KE

    更新日期:1987-08-01 00:00:00

  • P53 expression in choroid plexus neoplasms: an immunohistochemical study.

    abstract:OBJECTIVE:To evaluate choroid plexus neoplasms for p53 expression. CASE MATERIAL:We studied 10 choroid plexus tumors (four papillomas and six carcinomas) by immunohistochemistry using the DO7 anti-p53 monoclonal antibody. RESULTS:Three of four choroid plexus papillomas demonstrated no staining. Scattered nuclear and ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Jay V,Ho M,Chan F,Malkin D

    更新日期:1996-11-01 00:00:00

  • Hyalinizing spindle cell tumor with giant rosettes--a soft tissue tumor with mesenchymal and neuroendocrine features. An immunohistochemical, ultrastructural, and cytogenetic analysis.

    abstract:CONTEXT:Hyalinizing spindle cell tumor with giant rosettes is a recently described biphasic neoplasm of soft tissues that shares mesenchymal and neuroendocrine features. Its morphologic structure is distinctive, with the presence of hyalinized paucicellular foci that are termed rosettes. The cells around the latter dis...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2000)124<1179:HSCTWG>2.0.CO;2

    authors: Bejarano PA,Padhya TA,Smith R,Blough R,Devitt JJ,Gluckman JL

    更新日期:2000-08-01 00:00:00

  • Glomerulocystic kidney: one hundred-year perspective.

    abstract:CONTEXT:Glomerular cysts, defined as Bowman space dilatation greater than 2 to 3 times normal size, are found in disorders of diverse etiology and with a spectrum of clinical manifestations. The term glomerulocystic kidney (GCK) refers to a kidney with greater than 5% cystic glomeruli. Although usually a disease of the...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1043/1543-2165-134.4.583

    authors: Lennerz JK,Spence DC,Iskandar SS,Dehner LP,Liapis H

    更新日期:2010-04-01 00:00:00

  • DNA image cytometric analysis of primary clear cell carcinoma of the liver.

    abstract::Eleven cases of clear cell hepatocellular carcinoma were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. The tumors displayed a trabecular or solid pattern and contained between 40% and 90% clear cells. Five tumors (45.4%) were diploid and six tumors (54.5%) were nondiploid (fou...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Orsatti G,Arnold MM,Paronetto F

    更新日期:1994-12-01 00:00:00

  • Clinical implementation of KRAS testing in metastatic colorectal carcinoma: the pathologist's perspective.

    abstract:CONTEXT:Mutation status of the KRAS gene identifies a distinct disease subtype of metastatic colorectal carcinoma that does not respond to antibody therapeutics targeting the epidermal growth factor receptor. This is currently the only validated marker in metastatic colorectal carcinoma with a clear implication in trea...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2011-0478-RA

    authors: Ross JS

    更新日期:2012-10-01 00:00:00

  • Quality and liability issues with the Papanicolaou smear: lessons from the science of error prevention.

    abstract::The pathologists and cytologists who study Papanicolaou smears perform a highly successful cancer screening test in a low-prevalence population. This leads to a mathematically inevitable false-negative error rate even in the most competent professional hands. The US judicial system supports a public expectation of per...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Derman H

    更新日期:1997-03-01 00:00:00

  • Adenomyomatous hyperplasia of the gallbladder with perineural invasion.

    abstract::We report three examples of either localized or segmental adenomyomatous hyperplasia of the gallbladder in association with cholelithiasis. Two patients were women, 58 and 81 years of age, and the third was a 62-year-old man. The finding of perineural invasion by epithelial ductal structures in two cases and of perine...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Albores-Saavedra J,Henson DE

    更新日期:1995-12-01 00:00:00

  • Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies.

    abstract::We report a case of spindle-cell adenosquamous carcinoma of the esophagus. This represents the third case in the worldwide literature in which an esophageal polypoid tumor contains adenosquamous carcinoma rather than the usual squamous cell carcinoma in addition to a prominent spindle-cell element. The spindle-cell co...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Orsatti G,Corvalan AH,Sakurai H,Choi HS

    更新日期:1993-05-01 00:00:00

  • Pulmonary blastoma with malignant melanoma component.

    abstract::Pulmonary blastomas are rare primary tumors that consist of tubular or glandular structures embedded in an undifferentiated mesenchymal stroma. Focal cartilage, bone, and skeletal muscle as well as squamous differentiation have been described in these tumors. We report a unique case of a pulmonary blastoma showing a m...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Cohen RE,Weaver MG,Montenegro HD,Abdul-Karim FW

    更新日期:1990-10-01 00:00:00

  • Morphological features and healing of stress ulcers induced by alcohol and restraint.

    abstract::Gastric mucosal damage was produced in 130 mice by forced ingestion of alcohol, followed by restraint in the cold. Animals were killed at intervals from six hours to 27 days following the stress. Linear hemorrhagic erosions and diffuse hemorrhagic patches were found grossly, predominantly in the glandular portion of t...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Lev R,Kawashima K,Glass GB

    更新日期:1976-10-01 00:00:00

  • Squamous Neoplasia in the Esophagus.

    abstract:CONTEXT.—:Squamous lesions of the esophagus encompass a spectrum of disorders ranging from reactive changes and benign papilloma to squamous dysplasia and squamous cell carcinoma, which may pose diagnostic challenges especially in superficial biopsies. OBJECTIVE.—:To provide a review on the typical features of squamou...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2020-0058-RA

    authors: Savant D,Zhang Q,Yang Z

    更新日期:2020-04-09 00:00:00

  • Lymphovascular invasion in micropapillary urothelial carcinoma: a study of 22 cases.

    abstract:CONTEXT:Micropapillary urothelial carcinoma (MPUC) is a known aggressive variant of urothelial carcinoma. However, the reasons for its aggressiveness remain unclear. OBJECTIVE:To investigate the frequency of lymphovascular invasion in 22 cases of MPUC. DESIGN:Consecutive tissue sections were stained with D2-40 and CD...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2011-0463-OA

    authors: McQuitty E,Ro JY,Truong LD,Shen SS,Zhai Q,Ayala AG

    更新日期:2012-06-01 00:00:00

  • Primary angiitis of the central nervous system associated with Hodgkin's disease.

    abstract::An unusual case of primary angiitis of the central nervous system associated with Hodgkin's disease in a 55-year-old-man is reported. After a 10-month history of acute transverse myelitis, the patient was diagnosed as having nodular sclerosing-type Hodgkin's disease involving the retroperitoneal lymph nodes. The patie...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Yuen RW,Johnson PC

    更新日期:1996-06-01 00:00:00

  • The role of proficiency testing in ensuring quality: findings from the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference working group 3.

    abstract:CONTEXT:Implementation of proficiency testing for gynecologic cytology was delayed 20 years because of challenges addressing the subjective nature of cytologic interpretation and replicating normal working conditions. Concern remains regarding test scoring, slide validation, test environment, and other issues. How thes...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 共识发展会议,杂志文章

    doi:10.5858/arpa.2012-0094-OA

    authors: Howell LP,Nayar R,Savaloja L,Tabbara S,Thomas N,Winkler B,Tworek J

    更新日期:2013-02-01 00:00:00

  • Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test.

    abstract:CONTEXT:The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors expressed high levels of epidermal growth factor receptor (EGFR; immunohistochemistry score of ≥200 on a scale of 0-300). OBJECTIVE:To evaluate the interobserv...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0605-OA

    authors: Rüschoff J,Kerr KM,Grote HJ,Middel P,von Heydebreck A,Alves VA,Baldus SE,Büttner R,Carvalho L,Fink L,Jochum W,Lo AW,López-Ríos F,Marx A,Molina TJ,Olszewski WT,Rieker RJ,Volante M,Thunnissen E,Wrba F,Celik I,Stör

    更新日期:2013-09-01 00:00:00

  • Cystic osteolysis induced by silicone rubber prosthesis.

    abstract::Synovitic symptoms and radiologically documented cystic lesions in several carpal bones and distal radius developed two years after the implantation of silicone rubber scaphoid prosthesis for pseudoarthrosis. Open biopsy revealed granulomatous synovitis and osteitis and foreign material in carpal tissues. Ultrastructu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Ekfors TO,Aro H,Mäki J,Aho AJ

    更新日期:1984-03-01 00:00:00

  • Dialysis enhances renal epithelial proliferations.

    abstract::Study of 115 kidneys from 60 patients with chronic renal failure maintained by dialysis for two months to five years revealed an unexpected number and variety of epithelial proliferative processes, several types of which are hitherto unreported. Proliferative activity was defined either by the presence of epithelial s...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: McManus JF,Hughson MD,Hennigar GR,Fitts CT,Rajagopalan PR,Williams AV

    更新日期:1980-04-01 00:00:00

  • The causes of morbidity and mortality among infants born at term.

    abstract::Previous studies have reported on the pathologic spectrum of perinatal mortality; however, in our opinion, the problems pertaining to the term newborn have not been emphasized sufficiently. We reviewed the autopsies of all term infants up to 2 months of age in a ten-year period (July 1975 to July 1985). These 342 pati...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Rosenthal N,Abramowsky CR

    更新日期:1988-02-01 00:00:00

  • Carcinoembryonic antigen elevation due to bowel sequestration with mucocele formation following colonic resection.

    abstract::Carcinoembryonic antigen (CEA) is recommended as a serologic marker to monitor colorectal carcinoma recurrence. Elevations of CEA due to causes other than carcinoma exist and may lead to a misdiagnosis of recurrent carcinoma. We report a case of bowel sequestration with mucocele formation at the site of previous colo-...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2003)127<1376:CAEDTB>2.0.CO;2

    authors: Haber MM,Leon ME,Bakker JE,Nagle D

    更新日期:2003-10-01 00:00:00

  • Death certification errors at an academic institution.

    abstract:CONTEXT:The correctly completed death certificate provides invaluable personal, epidemiologic, and legal information and should be thorough and accurate. Death certification errors are common and range from minor to severe. OBJECTIVE:To determine the frequency and type of errors by nonpathologist physicians at a unive...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2005)129[1476:DCEAAA]2.0.CO;2

    authors: Pritt BS,Hardin NJ,Richmond JA,Shapiro SL

    更新日期:2005-11-01 00:00:00

  • Heat stroke. Report of three fatal cases with emphasis on findings in skeletal muscle.

    abstract::Three fatal cases of heat stroke were encountered in the central New York area over a two-month period. Although in each instance one or more predisposing factors were identified, exertion clearly played a role in its development in only one case. In addition to laboratory and postmortem findings indicative of dysfunc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Kim RC,Collins GH,Cho C,Ichikawa K,Givelber H

    更新日期:1980-07-01 00:00:00

  • Diabetic neuroarthropathy (Charcot's joint).

    abstract::The pathologic aspects of an uncommon complication of diabetes mellitus, destructive arthropathy (Charcot's joint), were studied. The peripheral nerve demyelination resulting in clinically demonstrable deficits in perception of pain and vibration and in reflexes in the lower extremities reinforces the neurogenic role ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Raju UB,Fine G,Partamian JO

    更新日期:1982-07-01 00:00:00

  • Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.

    abstract:OBJECTIVE:Pseudosarcomatous myofibroblastic tumors (PMTs) of the urogenital tract are rare but distinctive lesions. Despite their benign behavior, they are frequently misinterpreted as leiomyosarcomas and rhabdomyosarcomas in preoperative biopsies and even in resected specimens because of their atypical spindle-cell fe...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<1070:PMTAMO>2.0.CO;2

    authors: Watanabe K,Baba K,Saito A,Hoshi N,Suzuki T

    更新日期:2001-08-01 00:00:00

  • Pathologists as stewards of laboratory information.

    abstract::Just as electronic health records are transforming the practice of medicine and health care information management, practicing in the era of the electronic health record offers opportunities, if not imperatives, for pathologists to take on new and "transformative" professional and leadership roles for the organization...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2013-0714-SO

    authors: Henricks WH,Wilkerson ML,Castellani WJ,Whitsitt MS,Sinard JH

    更新日期:2015-03-01 00:00:00