Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimens.

abstract：:Fifty-three skin biopsy specimens obtained from the cutaneous rashes of patients who had dengue hemorrhagic fever (DHF) were studied by immunofluorescence technique. Six specimens showed deposits of IgM, beta 1 C-globulin, dengue antigen, and fibrinogen during the first week of fever. Some but not all of these compone...

journal_title：Archives of pathology & laboratory medicine

authors： Boonpucknavig S,Boonpucknavig V,Bhamarapravati N,Nimmannitya S

更新日期：1979-08-01 00:00:00

abstract：CONTEXT:Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4-probe multicolor FISH probe panel targeting chromos...

journal_title：Archives of pathology & laboratory medicine

authors： Gerami P,Zembowicz A

更新日期：2011-07-01 00:00:00

abstract：:A T-cell immunoblastic lymphoma having plasmacytoid features that mimic B-cell immunoblastic lymphoma, is described. The lesion was composed of sheets of pleomorphic plasmacytoid cells that displayed a helper T-cell immunophenotype (Leu-1+, Leu-3+, Leu-4+, Leu-5+, Leu-9-, Leu-2-). Ultrastructural features were consist...

journal_title：Archives of pathology & laboratory medicine

authors： Swanson S,Innes DJ Jr,Frierson HF Jr,Hess CE

更新日期：1987-11-01 00:00:00

abstract：:Yeast forms of Blastomyces dermatitidis typically range from 8 to 20 microm in largest diameter. We report a rare case of primary pulmonary blastomycosis with an unusual morphology, in which we found significant numbers of large yeast forms ranging from 30 to 35 microm in diameter. To our knowledge, this is only the s...

journal_title：Archives of pathology & laboratory medicine

authors： Hussain Z,Martin A,Youngberg GA

更新日期：2001-05-01 00:00:00

abstract：:We report a case of a malignant peripheral nerve sheath tumor arising in the distal femur of a 28-year-old man who had no stigmata of von Recklinghausen's disease. Roentgenograms and computed tomographic scans of the distal femur showed a single lytic intraosseous lesion with minimal soft tissue extension. Light micro...

journal_title：Archives of pathology & laboratory medicine

authors： Bullock MJ,Bedard YC,Bell RS,Kandel R

更新日期：1995-04-01 00:00:00

abstract：:The significance of an elevated free thyroxine index (FTI) as an indicator of hyperthyroidism was studied while screening 651 elderly nursing home residents. Eleven subjects had FTI elevations. Most of these patients were chronically ill and/or malnourished. Clinical assessment, repeated FTI determinations, and subseq...

journal_title：Archives of pathology & laboratory medicine

authors： Drinka PJ,Nolten WE,Voeks S,Langer E,Carlson IH

更新日期：1991-12-01 00:00:00

abstract：:Presented herein are the rationale, evolution, and present status of the alcian blue (AB)-aldehyde pararosaniline (AP) method for the selective staining of pancreatic beta-cell granules in paraffin sections of fixed tissues. Acidic mucins of pancreatic ductal and ductular cells and granules of mast cells and basophils...

journal_title：Archives of pathology & laboratory medicine

authors： Mowry RW

更新日期：1983-09-01 00:00:00

abstract：:The pathologic correlate of the clinical terms subendocardial and transmural applied to myocardial infarcts is uncertain. To examine this question, we reviewed the morphology of 204 hearts with single myocardial infarcts studied at autopsy after coronary arteriography and fixation in distention. The thickness of survi...

journal_title：Archives of pathology & laboratory medicine

authors： Pirolo JS,Moore GW,Hutchins GM

更新日期：1986-05-01 00:00:00

abstract：CONTEXT:Large disparities in prostate-specific antigen (PSA) results from different assays have been observed in the College of American Pathologists (CAP) Ligand Assay Survey, with interassay results varying severalfold. Survey specimens are predominately composed of free PSA and do not reflect the composition of typi...

journal_title：Archives of pathology & laboratory medicine

authors： Sokoll LJ,Witte DL,Klee GG,Chan DW

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E alleles epsilon2 and epsilon4 have been reported as independent risk factors for coronary artery disease (CAD) and as predictors for the development of atherosclerosis. METHODS AND RESULTS:We determined by polymerase chain reaction the distribution of apolipoprotein E polymorphism in 32...

journal_title：Archives of pathology & laboratory medicine

authors： Dzimiri N,Meyer BF,Hussain SS,Basco C,Afrane B,Halees Z

更新日期：1999-12-01 00:00:00

abstract：CONTEXT:The advent of new endoscopic optical techniques is likely to change pathologists' role in diagnosis. OBJECTIVE:To describe how confocal laser endomicroscopy (CLE) works, show its advantages and limitations compared to cytohistologic biopsy, and explore how it may affect the practice of pathology. DATA SOURCES...

journal_title：Archives of pathology & laboratory medicine

authors： Paull PE,Hyatt BJ,Wassef W,Fischer AH

更新日期：2011-10-01 00:00:00

abstract：CONTEXT:Correction factors have been proposed for estimating true potassium concentrations in blood samples with evidence of in vitro hemolysis. OBJECTIVE:We used 2 different models of true (ie, nonsimulated) in vitro hemolysis to evaluate the clinical utility of correction factors for estimating potassium concentrati...

journal_title：Archives of pathology & laboratory medicine

authors： Mansour MM,Azzazy HM,Kazmierczak SC

更新日期：2009-06-01 00:00:00

abstract：CONTEXT:Burkitt lymphoma (BL) is endemic in Uganda and because of the high incidence, diagnosis is often presumed during clinical care and epidemiologic studies. OBJECTIVES:To assess the accuracy of the clinical and the local pathology diagnosis of BL as assessed by an outside pathology review diagnosis and to underst...

journal_title：Archives of pathology & laboratory medicine

authors： Ogwang MD,Zhao W,Ayers LW,Mbulaiteye SM

更新日期：2011-04-01 00:00:00

abstract：CONTEXT:Automated cell counters use alerts (flags) to indicate which differential white blood cell counts can be released directly from the instrument and which samples require labor-intensive slide reviews. The thresholds at which many of these flags are triggered can be adjusted by individual laboratories. Many users...

journal_title：Archives of pathology & laboratory medicine

authors： Sireci A,Schlaberg R,Kratz A

更新日期：2010-10-01 00:00:00

abstract：:Multiple pulmonary leiomyomatous hamartomas (MPLHs) are extremely rare lesions. We present a case of MPLHs associated with a bronchogenic cyst in a symptomless, 46-year-old man. Previously, MLPHs have been reported to occur in men; therefore, not all cases of MPLHs represent metastases from a uterine smooth muscle tum...

journal_title：Archives of pathology & laboratory medicine

authors： Nistal M,Hardisson D,Riestra ML

更新日期：2003-04-01 00:00:00

abstract：CONTEXT:Although the value of pharmacogenomics to improve patient outcomes has become increasingly clear, adoption in medical practice has been slow, which can be attributed to several factors, including complicated and expensive testing procedures and required equipment, lack of training by private practice physicians...

journal_title：Archives of pathology & laboratory medicine

authors： Spizz G,Chen Z,Li P,McGuire IC,Klimkiewicz P,Zysling D,Yasmin R,Hungerford W,Thomas B,Wilding G,Mouchka G,Young L,Zhou P,Montagna RA

更新日期：2015-06-01 00:00:00

abstract：:In hyperlipemic swine, areas of the aortic arch that accumulate intravenously injected Evans blue dye (blue areas) appear to be more susceptible to early atherogenesis than adjacent areas that are devoid of dye uptake (white areas). We used immunofluorescence microscopy to determine the localization of apoprotein-B (a...

journal_title：Archives of pathology & laboratory medicine

authors： Feldman DL,Hoff HF,Gerrity RG

更新日期：1984-10-01 00:00:00

abstract：:The hemostatic response to vascular damage results in the focal generation of thrombin to produce a fibrin/platelet clot at the site of vascular injury. This regulated hemostatic response derives from the assembly and activity of enzyme complexes that are localized to surfaces presented by the vascular damage. The pro...

journal_title：Archives of pathology & laboratory medicine

authors： Mann KG,Lawson JH

更新日期：1992-12-01 00:00:00

abstract：:We report a case of silicone-induced endocarditis as a newly recognized complication of transvenous cardiac pacing catheterization. Silicone was found embedded in thrombotic vegetations on the tricuspid valve of a patient who had a long-standing pacing catheter in the right side of his heart. Scanning electron microsc...

journal_title：Archives of pathology & laboratory medicine

authors： Travis WD,Balogh K,Wolf BC,Doos WG,Abraham JL

更新日期：1986-01-01 00:00:00

abstract：:This study was undertaken to assess the specificity of split renal basement membranes in hereditary nephritis (HN). Thirteen specimens from eight patients with HN were mixed in a random fashion with specimens from control patients with either idiopathic nephrotic syndrome or various forms of glomerulonephritis and wit...

journal_title：Archives of pathology & laboratory medicine

authors： Kohaut EC,Singer DB,Nevels BK,Hill LL

更新日期：1976-09-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas are low-grade B-cell lymphomas that occur in a variety of extranodal sites but rarely as a primary hepatic lymphoma. We describe the histological findings, immunophenotype, and immunohistochemistry of one such lymphoma found incidentally in a 69-year-old woman. The ly...

journal_title：Archives of pathology & laboratory medicine

authors： Kirk CM,Lewin D,Lazarchick J

更新日期：1999-08-01 00:00:00

abstract：:Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium. This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. LCTs of the testis are frequently hormonally act...

journal_title：Archives of pathology & laboratory medicine

authors： Al-Agha OM,Axiotis CA

更新日期：2007-02-01 00:00:00

abstract：CONTEXT:- Pathologists routinely assess Ki67 immunohistochemistry to grade gastrointestinal and pancreatic neuroendocrine tumors. Unfortunately, manual counts of the Ki67 index are very time consuming and eyeball estimation has been criticized as unreliable. Manual Ki67 counts performed by cytotechnologists could poten...

journal_title：Archives of pathology & laboratory medicine

authors： Cottenden J,Filter ER,Cottreau J,Moore D,Bullock M,Huang WY,Arnason T

更新日期：2018-03-01 00:00:00

abstract：:The salivary glands, despite their relatively simple morphology, give rise to more than 30 histologically distinct benign and malignant tumors. Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. They arise in the parotid gland in 80% of cases, and approximately 8...

journal_title：Archives of pathology & laboratory medicine

authors： Schneider M,Rizzardi C

更新日期：2008-02-01 00:00:00

abstract：:Barrett's esophagus is a chronic condition in which the normal squamous mucosal lining is replaced by columnar mucosa. Campylobacter-like organism (CLOs) are implicated in the pathogenesis of gastritis and peptic ulcer disease and have been identified in Barrett's esophagus. The purpose of this study was to examine th...

journal_title：Archives of pathology & laboratory medicine

authors： Houck JA,Lucas JG

更新日期：1989-05-01 00:00:00

abstract：:The importance of demonstrating linearity for a clinical chemistry analytical system has caused considerable debate. Disagreement about the way linearity is demonstrated has led to some misunderstanding about just what linearity means to the analytical goals. In many cases where linearity is evaluated by statistical m...

journal_title：Archives of pathology & laboratory medicine

authors： Shires GW

更新日期：1992-07-01 00:00:00

abstract：CONTEXT:Methods to improve surgical pathology patient safety include measuring the frequency of error in specific steps of the surgical pathology testing process, root cause analysis of active and latent components, and implementation of quality improvement initiatives. OBJECTIVE:To determine the frequency and cause o...

journal_title：Archives of pathology & laboratory medicine

authors： Smith ML,Raab SS

更新日期：2011-11-01 00:00:00

abstract：:Krukenberg tumor is an uncommon metastatic tumor of the ovary. This article provides an overview of the major pathologic manifestations of Krukenberg tumor, patient characteristics, clinical and laboratory features of the disease, prognostic factors, and current knowledge about its pathogenesis. Pathologists have to b...

journal_title：Archives of pathology & laboratory medicine

authors： Al-Agha OM,Nicastri AD

更新日期：2006-11-01 00:00:00

abstract：CONTEXT:Dysregulation of mediators of apoptosis is associated with carcinogenesis. For biliary duct cancers, p53 gene mutation is an important contributor to carcinogenesis. Mutations in the p53 gene affect transcription of the Fas gene, resulting in lack of Fas expression on cell membrane. It has been previously shown...

journal_title：Archives of pathology & laboratory medicine

authors： Jhala NC,Vickers SM,Argani P,McDonald JM

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To investigate the possibility of a viral agent in the central nervous system of patients with epidemic neuropathy. DESIGN:Virus isolation attempts, in cell cultures and suckling mice, from cerebrospinal fluid (CSF) of neuropathy patients and controls undergoing lumbar puncture for unrelated reasons. Serolog...

journal_title：Archives of pathology & laboratory medicine

authors： Más P,Pelegrino JL,Guzmán MG,Comellas MM,Resik S,Alvarez M,Rodríguez R,Muné M,Capó V,Balmaseda A,Rodríguez L,Rodríguez MP,Handy J,Kourí G,Llop A

更新日期：1997-08-01 00:00:00