Validation of a Cytotechnologist Manual Counting Service for the Ki67 Index in Neuroendocrine Tumors of the Pancreas and Gastrointestinal Tract.

abstract：CONTEXT.—:The College of American Pathologists guidelines recommend testing additional tumor foci in multifocal invasive breast carcinomas for the biomarkers estrogen receptor (ER), progesterone receptor, and HER2 only if the carcinomas show different morphologies or grades. OBJECTIVE.—:To assess clinical significance...

journal_title：Archives of pathology & laboratory medicine

authors： Navale P,Bleiweiss IJ,Jaffer S,Nayak A

更新日期：2019-02-01 00:00:00

abstract：:Teratoid hepatoblastoma is a rare histologic subtype accounting for 4% to 10% of all hepatoblastomas and is characterized by the presence of divergent differentiation, including squamous, mucinous, melanocytic, cartilaginous, osseous, skeletal muscle, and neural elements. It is postulated that the teratoid elements mi...

journal_title：Archives of pathology & laboratory medicine

authors： Rabah R

更新日期：2012-08-01 00:00:00

abstract：CONTEXT:- Detection of variants in hematologic malignancies is increasingly important because of a growing number of variants impacting diagnosis, prognosis, and treatment response, and as potential therapeutic targets. The use of next-generation sequencing technologies to detect variants in hematologic malignancies in...

journal_title：Archives of pathology & laboratory medicine

authors： Thomas M,Sukhai MA,Zhang T,Dolatshahi R,Harbi D,Garg S,Misyura M,Pugh T,Stockley TL,Kamel-Reid S

更新日期：2017-06-01 00:00:00

abstract：CONTEXT:- Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE:- To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES:- Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the ...

journal_title：Archives of pathology & laboratory medicine

authors： Husain AN,Colby TV,Ordóñez NG,Allen TC,Attanoos RL,Beasley MB,Butnor KJ,Chirieac LR,Churg AM,Dacic S,Galateau-Sallé F,Gibbs A,Gown AM,Krausz T,Litzky LA,Marchevsky A,Nicholson AG,Roggli VL,Sharma AK,Travis WD,Walt

更新日期：2018-01-01 00:00:00

abstract：:Hibernomas are rare neoplasms composed of brown adipose tissue. The behavior of these neoplasms has been described as uniformly benign in humans. The only recurrence cited in the English literature involved a sarcoma with hibernoma-like features, which was reported in abstract form. We present 2 cases of hibernoma, on...

journal_title：Archives of pathology & laboratory medicine

authors： Lele SM,Chundru S,Chaljub G,Adegboyega P,Haque AK

更新日期：2002-08-01 00:00:00

abstract：:Silicone, commonly used in cosmetic procedures owing to its presumed inertness, can yield serious sequelae including acute embolization and pneumonitis. Chronic pulmonary sequelae in response to silicone injection have not been previously described. We report a case of chronic progressive granulomatous pneumonitis in ...

journal_title：Archives of pathology & laboratory medicine

authors： Hariri LP,Gaissert HA,Brown R,Ciaranello A,Greene RE,Selig MK,Kradin RL

更新日期：2012-02-01 00:00:00

abstract：:Public fascination with and support for genetic medicine is complicated by a deeply held fear that genetic information will be used by third parties (eg, insurers, employers, school systems) in ways that will harm the individuals from whom it was derived. Since the mid-1990s there has been much state and some federal ...

journal_title：Archives of pathology & laboratory medicine

authors： Reilly PR

更新日期：1999-11-01 00:00:00

abstract：:The fluorescent dye thioflavin T stains intensely the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavin T staining with electron microscopy was carried out in 25 patients and showed excellent congruity. Thioflavin T is much easier to use, but is less specific than ...

journal_title：Archives of pathology & laboratory medicine

authors： Churg J,Duffy JL,Bernstein J

更新日期：1979-02-01 00:00:00

abstract：CONTEXT:The immunophenotypic profile of basophils is not yet fully established, and the immunophenotypic changes in chronic myelogenous leukemia are not fully characterized. OBJECTIVE:To establish a comprehensive immunophenotypic spectrum of normal basophils and to assess the range of immunophenotypic aberrations of b...

journal_title：Archives of pathology & laboratory medicine

authors： Han X,Jorgensen JL,Brahmandam A,Schlette E,Huh YO,Shi Y,Awagu S,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Sensitivity, specificity, and predictive values are commonly used to report the performance characteristics of a diagnostic test. With tests that by their nature have more than two classes of results, calculation of sensitivity and specificity demands the combination of categories into two classes, leading to a loss o...

journal_title：Archives of pathology & laboratory medicine

authors： Giard RW,Hermans J

更新日期：1990-08-01 00:00:00

abstract：CONTEXT:Automated cell counters use alerts (flags) to indicate which differential white blood cell counts can be released directly from the instrument and which samples require labor-intensive slide reviews. The thresholds at which many of these flags are triggered can be adjusted by individual laboratories. Many users...

journal_title：Archives of pathology & laboratory medicine

authors： Sireci A,Schlaberg R,Kratz A

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Mutation status of the KRAS gene identifies a distinct disease subtype of metastatic colorectal carcinoma that does not respond to antibody therapeutics targeting the epidermal growth factor receptor. This is currently the only validated marker in metastatic colorectal carcinoma with a clear implication in trea...

journal_title：Archives of pathology & laboratory medicine

authors： Ross JS

更新日期：2012-10-01 00:00:00

abstract：CONTEXT:The development of targeted therapies creates a need to accurately classify tumors. Among the more pressing needs are the identification of the complete catalog of genes that are altered in cancer and the accurate discrimination of tumors based on their genetic background. OBJECTIVES:To discuss the use of gene...

journal_title：Archives of pathology & laboratory medicine

authors： Sanchez-Cespedes M

更新日期：2008-10-01 00:00:00

abstract：:A rare angiomyxoma of umbilica cord occurred in a male infant. The presence of such a tumor with its vascular component arising from a hypoplastic umbilical artery supports the hypothesis that the lesions arose through improper placental vascularization. ...

journal_title：Archives of pathology & laboratory medicine

authors： Carvounis EE,Dimmick JE,Wright VJ

更新日期：1978-04-01 00:00:00

abstract：CONTEXT:The pyrimidine nucleoside analog, cytosine arabinoside (Ara-C), is an effective therapeutic agent for acute leukemia. The phosphorylated triphosphate, cytosine arabinoside triphosphate, competes with deoxycytosine triphosphate as a substrate for incorporation into DNA. Once incorporated into DNA, it inhibits DN...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang X,Kiechle FL

更新日期：2004-12-01 00:00:00

abstract：:Peliotic lesions of the liver and spleen are rare and usually occur in patients with wasting diseases, such as tuberculosis and cancer, or in patients who have received treatment with anabolic-androgenic steroids. Peliosis appears grossly as blood-filled, cyst-like or nodular lesions, 1 to 5 mm in diameter, that are d...

journal_title：Archives of pathology & laboratory medicine

authors： Warfel KA,Ellis GH

更新日期：1982-02-01 00:00:00

abstract：:Accurate diagnosis of salivary gland tumors can be challenging because of the many diagnostic entities, the sometimes extensive morphologic overlap, and the rarity of most tumor types. Ancillary testing is beginning to ameliorate some of these challenges through access to newer immunohistochemical stains and fluoresce...

journal_title：Archives of pathology & laboratory medicine

authors： Griffith CC,Schmitt AC,Little JL,Magliocca KR

更新日期：2017-03-01 00:00:00

abstract：:We recently encountered an elderly female patient with multiple, rapidly growing vascular lesions on her forearm. Histologic examination and immunoperoxidase studies were performed to identify cells present within the lesions. The growths proved to be intravascular papillary endothelial hyperplasia. Immunohistochemica...

journal_title：Archives of pathology & laboratory medicine

authors： Stewart M,Smoller BR

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To determine the diagnostic accuracy of an investigational test for human immunodeficiency virus (HIV) envelope antibodies in urine. DESIGN:Matched blood and urine specimens were tested for HIV by two independent laboratories, both of which were blinded to all results at the other site. Duplicate positive en...

journal_title：Archives of pathology & laboratory medicine

authors： Berrios DC,Avins AL,Haynes-Sanstad K,Eversley R,Woods WJ

更新日期：1995-02-01 00:00:00

abstract：:The concentration of neuron-specific enolase (NSE, gamma-subunit of enolase) in tumor extracts of 25 nonargyrophilic and seven argyrophilic carcinomas of the female breast was measured by radioimmunoassay. The mean concentration of NSE in nonargyrophilic carcinomas was 89 ng/mg of protein, (range, 9 to 281 ng/mg), and...

journal_title：Archives of pathology & laboratory medicine

authors： Wilander E,Påhlman S,Sällström J,Lindgren A

更新日期：1987-09-01 00:00:00

abstract：:Toxoplasmosis of both donor and recipient hearts was diagnosed by means of endomyocardial biopsy specimens after heterotopic cardiac transplantation for dilated cardiomyopathy. Before transplantation, the donor had raised antibody titers to Toxoplasma, and the recipient was negative. When toxoplasmosis was diagnosed o...

journal_title：Archives of pathology & laboratory medicine

authors： Rose AG,Uys CJ,Novitsky D,Cooper DK,Barnard CN

更新日期：1983-07-01 00:00:00

abstract：:A review was made of the clinical histories, treatment, and renal histologic features of 12 patients with anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM disease). Two patients had milder histopathologic changes in their kidney biopsy specimens and achieved clinical remission. The other...

journal_title：Archives of pathology & laboratory medicine

authors： Stave GM,Croker BP

更新日期：1984-09-01 00:00:00

abstract：CONTEXT:Enterocytozoon bieneusi is the most frequent microsporidian parasite of human patients with acquired immunodeficiency syndrome and is a significant cause of diarrhea and wasting. Recently, this organism has also been recognized as a spontaneous infection of several species of captive macaques. As in humans, E b...

journal_title：Archives of pathology & laboratory medicine

authors： Chalifoux LV,Carville A,Pauley D,Thompson B,Lackner AA,Mansfield KG

更新日期：2000-10-01 00:00:00

abstract：CONTEXT:Autopsy continues to provide important data for quality assurance, teaching, scientific purposes, and health planning, especially if performed according to a comprehensive protocol. OBJECTIVE:To describe and analyze data from all perinatal and pediatric autopsies performed at a university hospital in Brazil. ...

journal_title：Archives of pathology & laboratory medicine

authors： Peres LC

更新日期：2006-01-01 00:00:00

abstract：CONTEXT:Two recent studies have identified a high rate of microsatellite instability (MSI) in pancreatic neuroendocrine tumors (pNETs). Microsatellite instability is rare in small intestinal neuroendocrine tumors (NETs). It is unclear why there is discordance in the frequency of MSI in the 2 studies of pNETs and why th...

journal_title：Archives of pathology & laboratory medicine

authors： Arnason T,Sapp HL,Rayson D,Barnes PJ,Drewniak M,Nassar BA,Huang WY

更新日期：2011-12-01 00:00:00

abstract：:In this article we present a case of an ectopic gestation having morphologic features of a partial hydatidiform mole and demonstrating triploidy by flow cytometry in a patient presenting at 9 weeks' gestation. We include brief comments on partial hydatidiform mole. ...

journal_title：Archives of pathology & laboratory medicine

authors： Montgomery EA,Roberts EF,Conran RM,Hitchcock CL

更新日期：1993-06-01 00:00:00

abstract：:A 9-year-old boy with metachromatic leukodystrophy (MLD) was found to have diffuse papillomatosis of the gallbladder that was virtually obliterating the lumen of the gallbladder. To our knowledge, two other examples of this lesion have been reported previously in MLD. ...

journal_title：Archives of pathology & laboratory medicine

authors： Burgess JH,Kalfayan B,Slungaard RK,Gilbert E

更新日期：1985-01-01 00:00:00

abstract：:A case of cystic cerebellar hemangioblastoma with previously unreported light and electron microscopic features is reported. Deposits of intranuclear, osmiophilic, lipid-like material produced unusual stromal cells, with distended clear nuclei similar to empty cysts at the light-microscopic level. This description exp...

journal_title：Archives of pathology & laboratory medicine

authors： Cerezo L,Herrera GA

更新日期：1981-06-01 00:00:00

abstract：:A 47-year-old man presented to the otolaryngologist with a 7-year history of a mass of the cheek. Fine-needle aspiration revealed foci of spindled cells admixed with abundant fat and myxoid material. A diagnosis of spindle cell lipoma was rendered on the resected specimen. The cytologic findings of spindle cell lipoma...

journal_title：Archives of pathology & laboratory medicine

authors： Fasig JH,Robinson RA,McCulloch TM,Fletcher MS,Miller CK

更新日期：2001-06-01 00:00:00

abstract：:Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign, proliferative mesenchymal lesion with possible hormonal etiology. It typically affects women in the reproductive age group. Pseudoangiomatous stromal hyperplasia is frequently an incidental histologic finding in breast biopsies performed for other...

journal_title：Archives of pathology & laboratory medicine

authors： Virk RK,Khan A

更新日期：2010-07-01 00:00:00