Systemic idiopathic fibrosis with T-cell receptor gene rearrangement.

Abstract:

:A case of systemic idiopathic fibrosis was analyzed by Southern blotting with probes to the immunoglobulin heavy chain and T-cell receptor genes. A 45-year-old man presented with bilateral neck swelling. He later developed lower back pain, and findings on a computed tomographic scan were consistent with idiopathic retroperitoneal fibrosis. A biopsy specimen of a neck lesion showed morphologic characteristics typical of idiopathic fibrosing cervicitis. Immunophenotyping of the lesion revealed a polymorphic lymphoid population. Molecular analysis with the use of probes to the immunoglobulin and T-cell receptor genes disclosed a germline DNA pattern for the immunoglobulin gene and a rearranged pattern for the T-cell receptor gene.

journal_name

Arch Pathol Lab Med

authors

Dent GA,Baird DB,Ross DW

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

80-3

issue

1

eissn

0003-9985

issn

1543-2165

journal_volume

115

pub_type

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