Antithrombin levels are unaffected by warfarin use.

Abstract:

CONTEXT:The results of studies among patients with antithrombin deficiency have suggested that the use of warfarin will increase the level of antithrombin. OBJECTIVE:To reevaluate the effect of warfarin on antithrombin levels using an automated amidolytic method in current use. DESIGN:Antithrombin levels were measured in patients who were receiving warfarin for atrial fibrillation and were compared with antithrombin levels in preoperative patients who had not received warfarin. RESULTS:Patients receiving warfarin had a mean antithrombin level of 100.40% (range, 81%-153%). Patients not receiving warfarin had a mean antithrombin level of 99.97% (range, 79%-120%). The Student t test was not significant for a difference between the mean antithrombin levels of the 2 populations. CONCLUSIONS:The use of warfarin does not increase the level of antithrombin in patients receiving the drug.

journal_name

Arch Pathol Lab Med

authors

Sanfelippo MJ,Engel JM,Onitilo AA

doi

10.5858/arpa.2013-0065-OA

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

967-8

issue

7

eissn

0003-9985

issn

1543-2165

journal_volume

138

pub_type

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